Skip to main content

5-Iodouracil

ADVERTISEMENT
Identification
Molecular formula
C4H3IN2O2
CAS number
696-07-1
IUPAC name
5-iodohexahydropyrimidine-2,4-dione
State
State

At room temperature, 5-Iodouracil is in a solid state, appearing as crystalline powder.

Melting point (Celsius)
235.00
Melting point (Kelvin)
508.20
Boiling point (Celsius)
336.90
Boiling point (Kelvin)
610.00
General information
Molecular weight
237.98g/mol
Molar mass
239.9600g/mol
Density
3.2740g/cm3
Appearence

5-Iodouracil typically appears as a white to off-white crystalline powder. Due to its iodine content, it may have a slightly darker appearance compared to similar compounds without iodine.

Comment on solubility

Solubility of 5-iodohexahydropyrimidine-2,4-dione

5-iodohexahydropyrimidine-2,4-dione (C4H3IN2O2) presents unique solubility characteristics that are noteworthy due to its structural composition. This compound may display variable solubility in different solvents based on factors such as polarity and functional groups:

  • Polarity: The presence of iodine and the carbonyl groups in this compound could influence interactions with polar solvents like water.
  • Solvent Selection: It may show enhanced solubility in organic solvents such as ethanol or methanol, where the molecular interactions are more favorable.
  • Hydrogen Bonding: The carbonyl functionalities may participate in hydrogen bonding, further affecting solubility in alcohols.

However, detailed empirical data may be required to provide **specific solubility values** and thus the solubility can be classified as:

  • Soluble: In organic solvents, potentially leading to good mixing and use in applications.
  • Insoluble: In water, indicating limited utility in aqueous environments without modification of its chemical structure.

In conclusion, the solubility of 5-iodohexahydropyrimidine-2,4-dione in various solvents can be a critical factor for its utilization in synthetic applications and formulations. Experimental assessment under specific conditions remains essential to determine its behavior accurately.

Interesting facts

Interesting Facts About 5-Iodohexahydropyrimidine-2,4-dione

5-Iodohexahydropyrimidine-2,4-dione is a fascinating compound in the realm of organic chemistry. Often classified as a pyrimidine derivative, it showcases numerous properties and applications that make it of great interest to scientists and researchers alike.

Key Characteristics

  • Structural Uniqueness: The incorporation of iodine in its structure not only contributes to the compound's reactivity but also makes it a pivotal building block for synthesizing various pharmaceuticals.
  • Diverse Applications: This compound is often explored in medicinal chemistry for its potential therapeutic effects, particularly in the synthesis of antiviral and anticancer agents.
  • Reactivity: The iodine atom is known to enhance electrophilic substitution reactions, which allows for the introduction of additional functional groups, thereby enriching the compound's chemical diversity.

Scientific Insights

According to studies, the unique combination of the hexahydropyrimidine skeleton with the dione functionality enables researchers to investigate new pathways for drug development. The presence of halogens like iodine often leads to improved biological efficacy in drug candidates, making this compound a valuable subject in pharmaceutical studies.

One notable point to emphasize is the role that heterocyclic compounds, specifically those containing nitrogen, play in biological systems. Pyrimidines are naturally occurring and found in essential biomolecules such as nucleotides and nucleic acids. This relationship underscores the significance of compounds like 5-iodohexahydropyrimidine-2,4-dione in both nature and synthetic chemistry.

Research Opportunities

  • Exploration of its metabolites and degradation products in biological systems.
  • Studying its interaction with biological targets through structure-activity relationship (SAR) studies.
  • Development of novel synthetic methodologies that utilize this compound as an intermediate.

In summary, 5-iodohexahydropyrimidine-2,4-dione represents an intriguing intersection of chemistry and biology, making it a compound of persistent interest for researchers dedicated to uncovering new horizons in drug discovery and synthesis.

Synonyms
5-Iodo-5,6-dihydrouracil
60763-80-6
5-iodo-1,3-diazinane-2,4-dione
5-iododihydropyrimidine-2,4(1h,3h)-dione
2,4(1H,3H)-Pyrimidinedione, dihydro-5-iodo-
SCHEMBL4997881
DTXSID60976237
5-Iodo-5,6-dihydropyrimidine-2,4-diol
PD042666
DB-296199