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Thymine

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Identification
Molecular formula
C5H6N2O2
CAS number
65-71-4
IUPAC name
5-(hydroxymethyl)-6-methyl-1H-pyrimidine-2,4-dione
State
State
Thymine is in a solid state at room temperature, often appearing as crystalline powder.
Melting point (Celsius)
316.00
Melting point (Kelvin)
589.15
Boiling point (Celsius)
287.00
Boiling point (Kelvin)
560.15
General information
Molecular weight
126.11g/mol
Molar mass
126.1130g/mol
Density
1.3584g/cm3
Appearence
Thymine is a white crystalline solid under normal conditions. It is not soluble in water or alcohol but can dissolve in dilute alkali solutions.
Comment on solubility

Solubility of 5-(hydroxymethyl)-6-methyl-1H-pyrimidine-2,4-dione

The solubility of 5-(hydroxymethyl)-6-methyl-1H-pyrimidine-2,4-dione can be characterized by several important considerations:

  • Polar Nature: The presence of hydroxymethyl (-CH2OH) groups tends to increase the polar character of the compound, which may enhance its solubility in polar solvents, such as water.
  • Hydrogen Bonding: With functional groups capable of forming hydrogen bonds, this compound may exhibit improved solubility compared to non-polar counterparts.
  • Solvent Compatibility: It is often soluble in organic solvents such as methanol or ethanol, but insoluble in non-polar solvents like hexane.

As a general rule, "like dissolves like" applies, making the chemical structure a key factor in solubility. Each solvent's polarity, combined with the compound's functional groups, plays a crucial role in determining how well it dissolves.

Thus, while empirical data might be needed for exact solubility measurements, understanding these underlying principles can provide a strong basis for predicting the behavior of 5-(hydroxymethyl)-6-methyl-1H-pyrimidine-2,4-dione in various solvents.

Interesting facts

Interesting Facts about 5-(Hydroxymethyl)-6-methyl-1H-pyrimidine-2,4-dione

5-(Hydroxymethyl)-6-methyl-1H-pyrimidine-2,4-dione, commonly known for its role in biochemical pathways, is a fascinating compound with several noteworthy attributes:

  • Biological Significance: This compound is part of the pyrimidine family, which includes important biomolecules such as nucleotides. Pyrimidines are essential for the synthesis of DNA and RNA, thereby playing a critical role in genetic information transmission.
  • Enzymatic Involvement: It is known to act as an intermediate in various enzymatic reactions, particularly in nucleotide metabolism. Its hydroxymethyl group adds unique reactivity, influencing enzyme catalysis.
  • Pharmaceutical Relevance: Researchers are interested in pyrimidinones like this compound for their potential therapeutic applications. They have shown promise in the development of antiviral and anticancer agents.
  • Research Applications: The compound is often utilized in synthetic organic chemistry as a building block in the preparation of more complex molecules due to its reactive functional groups. This makes it a subject of interest for chemists developing novel compounds.
  • Structural Features: The molecule's structure features a pyrimidine ring with both hydroxymethyl and methyl substituents, contributing to its unique properties. Such substitutions can significantly impact the compound's biological activity and stability.

In summary, 5-(hydroxymethyl)-6-methyl-1H-pyrimidine-2,4-dione is more than just a chemical compound; it embodies a fusion of chemistry, biology, and potential therapeutic innovation. As scientists delve deeper into its properties, who knows what new discoveries await?

Synonyms
147-61-5
5-Hydroxymethyl-6-methyluracil
PENTOXYL
5-(hydroxymethyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Pentoksil
5-Hydroxymethyl-4-methyluracil
4-Methyl-5-hydroxymethyluracil
Pentoxyuracil
4-Methyl-5-oxymethyluracil
5-(hydroxymethyl)-6-methyl-1H-pyrimidine-2,4-dione
5-(hydroxymethyl)-6-methylpyrimidine-2,4-diol
UNII-7LCS1FW4JV
7LCS1FW4JV
EINECS 205-694-0
MFCD00023156
NSC 13202
Uracil, 5-(hydroxymethyl)-6-methyl-
5-hydroxymethyl-6-methyl-2,4(1h,3h)-pyrimidinedione
PENTOXYL [MI]
NSC-13202
PENTOXYL [WHO-DD]
5-(Hydroxymethyl)-6-methyl-2,4(1H,3H)-pyrimidinedione
DTXSID20163560
5-(hydroxymethyl)-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
NSC667247
2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)-6-methyl-
5-hydroxymethyl-6-methyl-pyrimidine-2,4-diol
5-(Hydroxymethyl)-6-methyl-2,4-pyrimidinediol
5-(Hydroxymethyl)-6-methyluracil
2,4(1H,3H)-Pyrimidinedione,5-(hydroxymethyl)-6-methyl-
SCHEMBL61494
DTXCID5086051
CHEBI:165843
ALBB-005410
NSC13202
STK500531
STL517212
AKOS002316984
AKOS024274789
NSC-667247
SB57538
AC-29448
AS-77096
SY027635
DB-042891
CS-0199322
NS00024835
EN300-125289
Y10081
5-(hydroxymethyl)-6-methyl-pyrimidine-2,4-diol
AG-205/11955187
SR-01000390602
SR-01000507719
SR-01000390602-1
SR-01000507719-1
2,3H)-Pyrimidinedione, 5-(hydroxymethyl)-6-methyl-
Q27268517
2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)-6-methyl-(9CI)