Skip to main content

5-Fluorouracil

ADVERTISEMENT
Identification
Molecular formula
C4H3FN2O2
CAS number
51-21-8
IUPAC name
5-fluoro-6-hydroxy-hexahydropyrimidine-2,4-dione
State
State

At room temperature, 5-Fluorouracil is in a solid state. It is stable under normal conditions, but can decompose when exposed to light, which is why it often needs to be stored in opaque containers.

Melting point (Celsius)
282.00
Melting point (Kelvin)
555.15
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.15
General information
Molecular weight
130.08g/mol
Molar mass
130.0770g/mol
Density
1.4430g/cm3
Appearence

5-Fluorouracil appears as a white to almost white crystalline powder. It is typically odorless and has a slightly bitter taste. The crystalline nature of the compound can lead to a grainy texture when examined under a microscope.

Comment on solubility

Solubility of 5-fluoro-6-hydroxy-hexahydropyrimidine-2,4-dione

The solubility of 5-fluoro-6-hydroxy-hexahydropyrimidine-2,4-dione (C4H3FN2O2) is influenced by several factors:

  • Polarity: Due to the presence of hydroxyl and fluorine groups, this compound exhibits notable polarity, which generally enhances solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl (-OH) group can form hydrogen bonds with solvents, contributing to increased solubility.
  • Environmental pH: The solubility may vary with pH, as ionization can occur under different acidic or basic conditions, potentially affecting solubility dynamics.

In summary, while 5-fluoro-6-hydroxy-hexahydropyrimidine-2,4-dione is likely to be soluble in polar solvents due to its functional groups, the exact solubility characteristics can be complex, depending on environmental conditions. As with many compounds, the statement "solubility is a multifaceted topic" rings true, as various factors interplay to determine the behavior of substances in different solutions.

Interesting facts

Interesting Facts about 5-Fluoro-6-Hydroxy-Hexahydropyrimidine-2,4-Dione

5-Fluoro-6-hydroxy-hexahydropyrimidine-2,4-dione is a fascinating compound that falls within the realm of heterocyclic chemistry. This molecule showcases the diverse functionality of nitrogen-containing rings and offers numerous implications in various fields of study. Here are some intriguing aspects of this compound:

  • Medical Relevance: Compounds featuring pyrimidine structures are well-known for their biological activity. Many drugs developed to treat various conditions, especially in oncology, incorporate such frameworks due to their ability to modulate biological pathways.
  • Fluorine's Role: The presence of fluorine in this compound is particularly noteworthy. Fluorine atoms can significantly enhance the metabolic stability of drug candidates, thus prolonging their activity in biological systems.
  • Versatile Applications: The hydroxyl group within the compound can engage in hydrogen bonding, making it a potential candidate for the synthesis of larger molecules or as a building block in medicinal chemistry.
  • Synthesis Potential: The unique structure of 5-fluoro-6-hydroxy-hexahydropyrimidine-2,4-dione allows for various synthetic pathways, making it an interesting subject for organic synthesis and methodology development.
  • Research Prospects: Ongoing research into pyrimidine derivatives continues to unveil new properties and activities, indicating that compounds like this one could lead to the discovery of novel therapeutics in areas like antimicrobial and antiviral treatments.

In summary, 5-fluoro-6-hydroxy-hexahydropyrimidine-2,4-dione not only represents a specific molecular structure but also embodies the vast possibilities inherent in pyrimidine chemistry. As a chemist or student, exploring this compound opens the door to understanding the intricate connections between molecular structure and biological activity.

Synonyms
37103-91-6
5-fluoro-6-hydroxy-1,3-diazinane-2,4-dione
5-fluoro-6-hydroxydihydropyrimidine-2,4(1H,3H)-dione
2,4(1H,3H)-Pyrimidinedione, 5-fluorodihydro-6-hydroxy-
5-Fluoro-6-hydroxy-5,6-dihydrouracil
NSC528189
NSC 528189
5-Fluoro-6-hydroxyhydrouracil 1-hydrate
SCHEMBL11390371
DTXSID40958273
AWONXBGDFDRWRH-UHFFFAOYSA-N
AKOS006229889
NSC-528189
SB55608
DB-049069
CS-0107126
5-Fluoro-4,5-dihydropyrimidine-2,4,6-triol
D76697
5-Fluoro-6-hydroxydihydropyrimidine-2,4(1H,3H)-dione monohydrate