Interesting facts
Interesting Facts about 5-Fluoro-1H-pyrimidine-2,4-dione
5-Fluoro-1H-pyrimidine-2,4-dione, a noteworthy compound in the realm of organic chemistry, showcases the dynamic interplay between fluorine substitution and the pyrimidine ring structure. Here are some compelling facts about this intriguing molecule:
- Pyrimidine Derivative: This compound is a derivative of pyrimidine—a six-membered aromatic ring containing two nitrogen atoms. The presence of both carbon and nitrogen plays a critical role in the compound's reactivity and stability.
- Fluorine's Influence: The substitution of fluorine at the 5-position of the pyrimidine ring alters its electronic properties, which can enhance biological activity, making it an essential component in medicinal chemistry.
- Biological Relevance: Compounds related to this structure have been investigated for their potential as pharmacological agents, particularly in the development of anticancer drugs and antiviral therapies.
- Synthetic Pathways: The synthesis of 5-fluoro-1H-pyrimidine-2,4-dione can involve various methodologies, such as the reaction of an appropriate fluorinated precursor with a urea or ureide compound. This aspect underscores the versatility of organic synthesis techniques.
- Analytical Techniques: Advanced analytical methods like NMR and mass spectrometry are often employed to characterize this compound, providing insights into its structure and purity.
In summary, 5-fluoro-1H-pyrimidine-2,4-dione is more than just a chemical entity; it is a gateway to exploring new therapeutic avenues and understanding the complexities of aromatic nitrogen-containing compounds. As noted by indomitable chemist, "The beauty of organic chemistry lies in the myriad functionalities that a single molecular framework can offer."
Synonyms
5-Fluorouracil
fluorouracil
51-21-8
5-FU
Fluoroplex
Efudex
Adrucil
Carac
Fluracil
Fluoroblastin
Queroplex
5-fluoropyrimidine-2,4(1H,3H)-dione
Phthoruracil
Carzonal
Kecimeton
Fluril
Fluracilum
Timazin
Arumel
Efudix
Ulup
5-Fluoracil
Fluorouracilum
5-fluoro-1H-pyrimidine-2,4-dione
Fluro Uracil
5 Fluorouracil
5-Fluoruracil
Fluorouracilo
Ftoruracil
Fluri
5-Fluoro-2,4(1H,3H)-pyrimidinedione
Effluderm (free base)
Fluroblastin
5-Fluoropyrimidine-2,4-dione
Efurix
Fluoro-uracile
Fluoro-uracilo
Uracil, 5-fluoro-
Ro 2-9757
5-Faracil
Cinco FU
Fluorouracile
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
2,4-Dihydroxy-5-fluoropyrimidine
5-fluoro-uracil
5-Fluor-2,4-pyrimidindiol
5-fluoropyrimidine-2,4-diol
2,4-Dioxo-5-fluoropyrimidine
Fluorouricil
NSC-19893
5-Fluoropyrimidin-2,4-diol
5-fluoro uracil
5-Ftouracyl
5-Fluoro-2,4-pyrimidinedione
NSC 19893
Fluorouracil Cream
5-Fluor-2,4-dihydroxypyrimidin
Fluorouracil, 5-
Ro-2-9757
U-8953
Fluorouracilum [INN-Latin]
Fluorouracilo [INN-Spanish]
Fluouracil
CCRIS 2582
Tolak
191047-65-1
Fluoro Uracil
HSDB 3228
5-Fluracil
EINECS 200-085-6
FU
5-Fluor-2,4(1H,3H)-pyrimidindion
UNII-U3P01618RT
5 FU
5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione
DTXSID2020634
CHEBI:46345
AI3-25297
U3P01618RT
NSC19893
MFCD00006018
Ro-29757
5FU
CHEMBL185
2,4-Pyrimidinediol, 5-fluoro- (9CI)
DTXCID40634
MLS000069498
191047-64-0
191115-88-5
Phtoruracil
EC 200-085-6
URF
Fluorouracil [USAN:USP:INN:BAN:JAN]
NCGC00015442-02
Effluderm
SMR000038082
Fluorouracile [DCIT]
5-Fluoracil [German]
5-Fluoracyl
5-Fluoruracil [German]
Fluorouracilum (INN-Latin)
Fluorouracilo (INN-Spanish)
FLUOROURACIL (MART.)
FLUOROURACIL [MART.]
1004-03-1
FLUOROURACIL (USP-RS)
FLUOROURACIL [USP-RS]
5-FLUOROURACIL (IARC)
5-FLUOROURACIL [IARC]
Flurablastin
FLUOROURACIL (EP MONOGRAPH)
FLUOROURACIL [EP MONOGRAPH]
FLUOROURACIL (USP MONOGRAPH)
FLUOROURACIL [USP MONOGRAPH]
CAS-51-21-8
Fluoroplex (TN)
5-Fluor-2,4-pyrimidindiol [Czech]
Fluorouracil (USAN:USP:INN:BAN:JAN)
Adrucil (TN)
Carac (TN)
FLUCYTOSINE IMPURITY A (EP IMPURITY)
FLUCYTOSINE IMPURITY A [EP IMPURITY]
5-Fluor-2,4-dihydroxypyrimidin [Czech]
SR-01000075881
5-Fluor-2,4(1H,3H)-pyrimidindion [Czech]
inhibits thymilidate synthetase
AccuSite
2,4-Dioxo-5-fluoropryimidine
5-fluorourasil
5-florouracil
5-fluorouacil
5 Fluorouracilum
5-FU (TN)
1upf
5F-uracil
U 8953
Fluorouracil; 5-Fluoropyrimidine-2,4(1H,3H)-dione; Flucytosine Imp. A (EP); Flucytosine Impurity A
Adrucil (ICN)
2794-13-0
Adrucil (Fluorouracil)
Spectrum_000841
Opera_ID_134
5-Fluorouracil, 99%
Spectrum2_000076
Spectrum3_000434
Spectrum4_000557
Spectrum5_000718
WLN: T6MVMVJ EF
FLUOROURACIL [MI]
Lopac-F-6627
F0151
5-Fluorouracil (5-FU)
FLUOROURACIL [INN]
FLUOROURACIL [JAN]
5-Fluorouracil (Standard)
UPCMLD-DP130
F 6627
FLUOROURACIL [HSDB]
FLUOROURACIL [USAN]
SCHEMBL3646
5-fluorpyrimidin-2,4-diol
FLUOROURACIL [VANDF]
Folfox component fluorouracil
Lopac0_000536
BSPBio_002048
FLUCYTOSINE IMPURITY A
KBioGR_001253
KBioSS_001321
2(1H)-Pyrimidinone, 5-fluoro-4-hydroxy- (9CI)
4(3H)-Pyrimidinone, 5-fluoro-2-hydroxy- (9CI)
MLS002415705
DivK1c_000054
FLUOROURACIL [WHO-DD]
FLUOROURACIL [WHO-IP]
SPECTRUM1500305
SPBio_000291
EMTRICITABINE IMPURITY F
5-fluoro-2,4-dioxo-pyrimidin
5-fluoro-pyrimidine-2,4-diol
GTPL4789
UPCMLD-DP130:001
Fluorouracil (JP18/USP/INN)
HMS500C16
KBio1_000054
KBio2_001321
KBio2_003889
KBio2_006457
KBio3_001268
5-Fluoro-2,3H)-pyrimidinedione
5-FLUOROURACIL [WHO-IP]
L01BC02
2,4-Pyrimidinedione, 5-fluoro-
NINDS_000054
BCPP000428
FLUOROURACIL [ORANGE BOOK]
HMS1920O18
HMS2090I04
HMS2091F19
HMS3259O03
HMS3261L13
HMS3654K22
HMS3715H03
HMS3865L03
Pharmakon1600-01500305
5-Fluorouracil, analytical standard
BCP02083
TCA94195
2,3H)-Pyrimidinedione, 5-fluoro-
5-Fluorouracil - Bio-X trade mark
Fluorouracil (5-Fluoracil, 5-FU)
Fluorouracil (5-Fluoracil; 5-FU)
Tox21_110150
Tox21_202335
Tox21_300112
Tox21_500536
BDBM50340677
CCG-39879
DL-399
HY-90006R
NSC757036
NSC816997
s1209
STK297802
STL367375
FLUOROURACILUM [WHO-IP LATIN]
AKOS000119162
AKOS003237897
AKOS008044307
Tox21_110150_1
BCP9000239
CS-0993
DB00544
FF05372
KS-5129
LP00536
NC00454
NSC-757036
NSC-816997
SDCCGSBI-0050519.P005
FLUCYTOSINE IMPURITY A [WHO-IP]
IDI1_000054
NCGC00015442-01
NCGC00015442-03
NCGC00015442-04
NCGC00015442-05
NCGC00015442-06
NCGC00015442-07
NCGC00015442-08
NCGC00015442-09
NCGC00015442-10
NCGC00015442-11
NCGC00015442-12
NCGC00015442-15
NCGC00015442-16
NCGC00015442-24
NCGC00015442-30
NCGC00091349-01
NCGC00091349-02
NCGC00091349-03
NCGC00091349-04
NCGC00091349-05
NCGC00091349-07
NCGC00091349-08
NCGC00254023-01
NCGC00259884-01
NCGC00261221-01
5-Fluoro-2,4(1H, 3H)-pyrimidinedione
5-Fluoropyrimidine-2,4-(1H,3H)-dione
AC-11201
BF166014
EMTRICITABINE IMPURITY F [WHO-IP]
HY-90006
NCI60_001652
SRI-10792-04
SRI-10792-05
SRI-10792-06
SRI-10792_07
SRI-10792_08
5-Fluoro-1H-pyrimidine-2,4-dione(5FU)
5-Fluorouracil, >=99% (HPLC), powder
SBI-0050519.P004
2(1H)-Pyrimidinone, 5-fluoro-4-hydroxy-
4(3H)-Pyrimidinone, 5-fluoro-2-hydroxy-
5-Fluoro-1H-pyrimidine-2,4-dione(5-FU)
DB-051923
DB-065735
DB-268958
DB-272209
DB-297613
pyrimidine-2,4(1H,3H)-dione, 5-fluoro-
5-Fluoro-1H-pyrimidine-2,4-dione (5-FU)
EU-0100536
NS00000337
SW199617-3
5-Fluoro-1H-pyrimidine-2,4-dione(5-FUra)
5-FLUOROPYRIMIDIN-2,4(1H,3H)-DIONE
EN300-33909
Fluorouracil, meets USP testing specifications
C07649
D00584
5-Fluorouracil, Vetec(TM) reagent grade, >=99%
Q238512
W-60379
(5-fluorouracil)5-Fluoro-1H-pyrimidine-2,4-dione
5-Fluoro-1H-pyrimidine-2,4-dione(5-fluoro uracil)
SR-01000075881-1
SR-01000075881-3
SR-01000075881-5
5-Fluoro-1H-pyrimidine-2,4-dione (5-Fluorouracil)
BRD-K24844714-001-02-1
BRD-K24844714-001-24-5
BRD-K24844714-001-25-2
5-FLUOROPYRIMIDIN-2,4(1H,3H)-DIONE [WHO-IP]
Z275128052
5-Fluoro-1H-pyrimidine-2,4-dione(5-fluorouracil)(5-FU)
5-Fluorouracil, certified reference material, TraceCERT(R)
Fluorouracil, British Pharmacopoeia (BP) Reference Standard
Fluorouracil, European Pharmacopoeia (EP) Reference Standard
Fluorouracil, United States Pharmacopeia (USP) Reference Standard
pyrimidine antimetabolite: inhibits nucleic acid replication; tetratogen
2,4-Dihydroxy-5-fluoropyrimidine;5-FU;5-Fluoro-2,4(1H,3H)-pyrimidinedione
5FU;5-FU;2,4-Dihydroxy-5-fluoropyrimidine;5-Fluoro-2,4(1H,3H)-pyrimidinedione
Fluorouracil, Pharmaceutical Secondary Standard; Certified Reference Material
InChI=1/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9
200-085-6
Solubility of 5-fluoro-1H-pyrimidine-2,4-dione (C4H3FN2O2)
The solubility of 5-fluoro-1H-pyrimidine-2,4-dione showcases interesting characteristics pertinent to its molecular structure. This compound contains a fluorine atom and a pyrimidine ring, both of which play significant roles in influencing its solubility in various solvents.
General Solubility Characteristics
Conclusion
In summary, while the exact solubility information of 5-fluoro-1H-pyrimidine-2,4-dione might vary based on environmental conditions, it can be noted that:
Understanding the solubility of this compound is crucial in various applications, especially in pharmaceutical and chemical research, where its interactions in different environments can have significant implications.