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Phenobarbital

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Identification
Molecular formula
C12H12N2O3
CAS number
50-06-6
IUPAC name
5-ethyl-5-phenyl-hexahydropyrimidine-4,6-dione
State
State

At room temperature, phenobarbital is a solid. It is stable under ordinary conditions of use and storage.

Melting point (Celsius)
175.00
Melting point (Kelvin)
448.15
Boiling point (Celsius)
297.00
Boiling point (Kelvin)
570.15
General information
Molecular weight
232.24g/mol
Molar mass
232.2360g/mol
Density
1.1000g/cm3
Appearence

Phenobarbital is typically encountered as a white crystalline powder. It is odorless and has a slightly bitter taste which is characteristic of many barbiturates. The powder is often used in tablet form for medicinal purposes.

Comment on solubility

Solubility of 5-ethyl-5-phenyl-hexahydropyrimidine-4,6-dione

The solubility of 5-ethyl-5-phenyl-hexahydropyrimidine-4,6-dione (C12H12N2O3) can be considered through various solvents and conditions. Typically, *organic compounds* such as this one exhibit a range of solubility behaviors, influenced by several factors.

Factors Affecting Solubility

  • Polarity: The presence of polar functional groups (like carbonyls) can enhance solubility in polar solvents such as water.
  • Hydrophobic Characteristics: The ethyl and phenyl groups contribute to hydrophobic interactions, making the compound less soluble in water but potentially more soluble in organic solvents.
  • Temperature: Generally, increased temperature can improve solubility for many organic compounds.
  • pH Level: The ionization state of the compound can vary with pH, potentially affecting solubility in aqueous solutions.

Moreover, it is essential to perform empirical tests to ascertain the solubility of 5-ethyl-5-phenyl-hexahydropyrimidine-4,6-dione in specific solvents, as theoretical predictions can often provide only an estimated range. As a rule of thumb, "like dissolves like", indicating that nonpolar solvents will better dissolve this organic molecule compared to polar solvents, despite some solubility being possible in the right conditions.

In conclusion, the solubility of 5-ethyl-5-phenyl-hexahydropyrimidine-4,6-dione is influenced by several interplaying factors, and understanding these can help in various applications in chemistry.

Interesting facts

5-Ethyl-5-phenyl-hexahydropyrimidine-4,6-dione: Fascinating Insights

5-Ethyl-5-phenyl-hexahydropyrimidine-4,6-dione is a remarkable compound that belongs to the pyrimidine family, which is known for its diverse applications in pharmaceuticals and organic synthesis. Here are some intriguing aspects of this compound:

  • Unique Structure: The hexahydropyrimidine ring in this compound contributes to its unique chemical properties and potential reactivity.
  • Biological Relevance: Compounds of similar structure are often investigated for their biological activities. Research has shown that pyrimidine derivatives can exhibit significant pharmacological properties, making this compound a potential candidate for drug development.
  • Synthesis Versatility: The synthetic pathways leading to compounds like 5-ethyl-5-phenyl-hexahydropyrimidine-4,6-dione are of great interest in organic chemistry. They often involve multi-step reactions that can introduce various functional groups for enhanced reactivity.
  • Application Potential: This compound's structural elements may allow it to act as a versatile building block for synthesizing more complex molecules, opening avenues in medicinal chemistry and material science.
  • Research Interest: Ongoing studies are focused on exploring the antioxidant properties and other beneficial effects that derivatives of pyrimidinediones may offer.

In summary, 5-ethyl-5-phenyl-hexahydropyrimidine-4,6-dione stands out as a compound with significant potential. Its intriguing structure and the biological implications of its derivatives continue to inspire research in various scientific fields. As chemists delve deeper into its properties, who knows what new discoveries may unfold?

Synonyms
primidone
125-33-7
Primaclone
Mysoline
Lepimidin
2-Deoxyphenobarbital
Neurosyn
Liskantin
Mylepsinum
Lepsiral
Misodine
Mizodin
Mylepsin
Mysedon
Primidon
Sertan
2-Desoxyphenobarbital
Hexadiona
Majsolin
Milepsin
Misolyne
Prilepsin
Primacone
Primakton
Primoline
Prysoline
Resimatil
Midone
Mizolin
Cyral
Medi-Pets
Primidona
Desoxyphenobarbitone
Pyrimidone Medi-pets
Primacione
Primidonum
5-ethyl-5-phenyl-1,3-diazinane-4,6-dione
5-Phenyl-5-ethyl-hexahydropyrimidine-4,6-dione
4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-phenyl-
Roe 101
5-Ethyldihydro-5-phenyl-4,6(1H,5H)-pyrimidinedione
Primidone (primaclone)
5-ethyl-5-phenyldihydropyrimidine-4,6(1H,5H)-dione
5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione
NCI-C56360
CHEBI:8412
5-Ethylhexahydro-4,6-dioxo-5-phenylpyrimidine
5-Ethylhexahydro-5-phenylpyrimidine-4,6-dione
NSC 41701
NSC-41701
Primidone(Mysoline)
5-Aethyl-5-phenyl-hexahydropyrimidin-4,6-dion
DTXSID7023510
13AFD7670Q
5-Phenyl-5-aethylhexahydropyrimidindion-(4,6)
MFCD00038662
MLS000028593
DTXCID603510
Myidone
NSC41701
NCGC00015834-11
CAS-125-33-7
SMR000058501
PRIMIDONE (IARC)
PRIMIDONE [IARC]
PRIMIDONE (MART.)
PRIMIDONE [MART.]
PRIMIDONE (USP-RS)
PRIMIDONE [USP-RS]
Primidonum [INN-Latin]
Primidona [INN-Spanish]
PRIMIDONE (EP IMPURITY)
PRIMIDONE [EP IMPURITY]
PRIMIDONE (EP MONOGRAPH)
PRIMIDONE [EP MONOGRAPH]
PRIMIDONE (USP MONOGRAPH)
PRIMIDONE [USP MONOGRAPH]
Hexamidine (the antispasmodic)
CCRIS 54
Mysoline (TN)
HSDB 3169
SR-01000003162
EINECS 204-737-0
BRN 0218034
Hexamidine(the antispasmodic)
Primadon
5-Aethyl-5-phenyl-hexahydropyrimidin-4,6-dion [German]
5-Phenyl-5-aethylhexahydropyrimidindion-(4,6) [German]
UNII-13AFD7670Q
Mylepsin Tablets
Neurosyn Tablets
Primidone [USP:INN:BAN:JAN]
Primidonum (Latin)
HEXAMYDIN
Primidone (Mysoline)
Primidone (Standard)
Spectrum_000832
Tocris-0830
Pyrimidone 'Medi-pets'
A1AIA
Mysoline, Apo-Primidone
PRIMIDONE [INN]
PRIMIDONE [JAN]
PRIMIDONE [MI]
PRIMIDONE [HSDB]
Opera_ID_1083
Prestwick0_000933
Prestwick1_000933
Prestwick2_000933
Prestwick3_000933
Spectrum2_001293
Spectrum3_000553
Spectrum4_000485
Spectrum5_001144
Lopac-P-7295
PRIMIDONE [VANDF]
Biomol-NT_000261
CHEMBL856
P 7295
Pyrimidone ''Medi-pets''
PRIMIDONE [WHO-DD]
Lopac0_001021
SCHEMBL34221
BSPBio_000866
BSPBio_002225
KBioGR_000969
KBioSS_001312
5-24-08-00102 (Beilstein Handbook Reference)
MLS001055411
MLS001074125
BIDD:GT0319
DivK1c_000324
Primidone, analytical standard
SPECTRUM1500501
Mylepsin, Primidone Medi-Pets
Primidone - Bio-X trade mark
SPBio_001325
SPBio_003035
Primidone (JP18/USP/INN)
PRIMIDONE [GREEN BOOK]
BPBio1_000859
BPBio1_000954
GTPL5338
PRIMIDONE [ORANGE BOOK]
HMS501A06
HY-B0339R
KBio1_000324
KBio2_001312
KBio2_003880
KBio2_006448
KBio3_001725
Primidone for peak identification
WLN: T6MV DVMTJ C2 CR
HEXAMIDINE (ANTIEPILEPTIC)
N03AA03
NINDS_000324
HMS1570L08
HMS1920J20
HMS2092A21
HMS2097L08
HMS2236G03
HMS3259K04
HMS3263M03
HMS3266H18
HMS3369J12
HMS3411N13
HMS3655L05
HMS3675N13
HMS3714L08
HMS3884A18
Pharmakon1600-01500501
HY-B0339
Tox21_110238
Tox21_201948
Tox21_303194
Tox21_501021
BDBM50248152
CCG-39231
NSC757291
s1965
AKOS003368409
Tox21_110238_1
DB00794
FP05584
KS-5217
LP01021
NC00532
NSC-757291
SDCCGSBI-0050994.P005
IDI1_000324
SMP1_000135
NCGC00015834-01
NCGC00015834-02
NCGC00015834-03
NCGC00015834-04
NCGC00015834-05
NCGC00015834-06
NCGC00015834-07
NCGC00015834-08
NCGC00015834-09
NCGC00015834-10
NCGC00015834-12
NCGC00015834-13
NCGC00015834-14
NCGC00015834-15
NCGC00015834-16
NCGC00015834-17
NCGC00015834-19
NCGC00015834-28
NCGC00016377-01
NCGC00023254-02
NCGC00023254-04
NCGC00023254-05
NCGC00023254-06
NCGC00023254-07
NCGC00023254-08
NCGC00023254-09
NCGC00023254-10
NCGC00257146-01
NCGC00259497-01
NCGC00261706-01
BP166193
SY052118
SBI-0050994.P004
AB00052079
EU-0101021
NS00000208
P1906
SW196576-3
5-Ethyldihydro-5-phenyl-4,5H)-pyrimidinedione
5-Ethylhexahydro-4,6-dioxo-5-phenylphrimidine
C07371
C71997
D00474
AB00052079-14
AB00052079_15
AB00052079_16
4,5H)-Pyrimidinedione, 5-ethyldihydro-5-phenyl-
A805374
Q420383
SR-01000003162-2
SR-01000003162-4
SR-01000003162-5
SR-01000003162-8
5-PHENYL-5-ETHYLHEXAHYDROPYRIMIDINE-4,6-DIONE
BRD-K32247306-001-05-4
BRD-K32247306-001-17-9
BRD-K32247306-001-27-8
BRD-K32247306-001-28-6
BRD-K32247306-001-29-4
5-Ethyl-5-phenyldihydro-4,6(1H,5H)-pyrimidinedione #
Z1509139960
5-Ethyl-5-phenyl-2,3-dihydropyrimidine-4,6(1H,5H)-dione
5-ETHYLDIHYDRO-5-PHENYL-4,6(1H,5H)PYRIMIDINEDIONE
Primidone, European Pharmacopoeia (EP) Reference Standard
Primidone, United States Pharmacopeia (USP) Reference Standard
Primidone for peak identification, European Pharmacopoeia (EP) Reference Standard
204-737-0