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Thiopental

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Identification
Molecular formula
C11H18N2O2S
CAS number
76-75-5
IUPAC name
5-ethyl-5-(1-methylbutyl)-2-sulfanyl-1H-pyrimidine-4,6-dione
State
State

At room temperature, thiopental is typically in a solid state as a crystalline powder. It is often mixed with other substances for use in clinical settings.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.00
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.00
General information
Molecular weight
264.35g/mol
Molar mass
264.3660g/mol
Density
1.1506g/cm3
Appearence

Thiopental is a white to off-white crystalline powder. It may have a slight characteristic odor.

Comment on solubility

Solubility of 5-ethyl-5-(1-methylbutyl)-2-sulfanyl-1H-pyrimidine-4,6-dione

The solubility of 5-ethyl-5-(1-methylbutyl)-2-sulfanyl-1H-pyrimidine-4,6-dione (C11H18N2O2S) can be quite complex and is influenced by various factors. Understanding its solubility is crucial for applications in pharmaceuticals and organic chemistry. Here are some key points regarding its solubility:

  • Polar vs. Non-polar: Due to the presence of a sulfanyl (-SH) group and a carbonyl (C=O) moiety, this compound tends to exhibit moderate polar characteristics. As a result, it may show some solubility in polar solvents.

  • Solvent Compatibility: The compound is more likely to dissolve in polar aprotic solvents such as dimethyl sulfoxide (DMSO) or acetonitrile, compared to non-polar solvents like hexane.

  • Hydrophobic Regions: The branched hydrocarbon chain (1-methylbutyl) provides hydrophobic characteristics that can impede solubility in water, making it less soluble in this solvent.

  • Temperature Effects: Increased temperature often enhances solubility; therefore, conducting experiments at various temperatures might yield better solubility profiles.

  • pH Influence: The ionization state of the compound can significantly impact its solubility. Changes in pH may lead to shifts in protonation of the nitrogen or sulfur atoms, affecting overall solubility behavior.

In conclusion, while 5-ethyl-5-(1-methylbutyl)-2-sulfanyl-1H-pyrimidine-4,6-dione may have *limited solubility in water*, it is important to assess it in a variety of solvents and conditions to better understand its behavior.

Interesting facts

Interesting Facts about 5-ethyl-5-(1-methylbutyl)-2-sulfanyl-1H-pyrimidine-4,6-dione

The compound 5-ethyl-5-(1-methylbutyl)-2-sulfanyl-1H-pyrimidine-4,6-dione presents a fascinating study opportunity for chemists due to its unique structure and potential applications. Here are some interesting aspects to consider:

  • Structural Complexity: This compound belongs to the pyrimidine family, a class of organic compounds characterized by a six-membered heterocyclic ring containing two nitrogen atoms. The addition of sulfur in its structure as a sulfanyl group adds to its complexity and potential reactivity.
  • Biological Significance: Pyrimidine derivatives are crucial in biochemistry. They form the basis of nucleotides, the building blocks of nucleic acids like DNA and RNA, making them essential for genetic information. Compounds similar to this one may have biological activity and could be evaluated for medicinal properties.
  • Reaction Pathways: The unique functional groups present in this compound could lead to a variety of chemical reactions. For example, the sulfanyl group might participate in nucleophilic substitutions or redox reactions, which are of interest in synthetic and pharmaceutical chemistry.
  • Synthesis Routes: The synthesis of this compound involves multiple steps that highlight the creativity required in organic synthesis. Chemists often explore various pathways to achieve the final compound, making the understanding of reaction mechanisms particularly important.
  • Potential Applications: Beyond its fundamental significance, compounds like this one might be explored for applications in agricultural chemistry, such as in pest control or plant growth regulation, due to the broad breadth of compounds derived from heterocycles.

In conclusion, the study of 5-ethyl-5-(1-methylbutyl)-2-sulfanyl-1H-pyrimidine-4,6-dione not only enhances our understanding of chemical reactivity and biological significance but also opens doors to innovative applications in different scientific fields. As research continues, the exploration of this and similar compounds may yield exciting breakthroughs in chemistry and medicinal science.