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Zalcitabine

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Identification
Molecular formula
C9H13N3O4
CAS number
7481-89-2
IUPAC name
5-ethyl-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione
State
State

At room temperature, Zalcitabine is in a solid state.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
150.50
Boiling point (Kelvin)
423.65
General information
Molecular weight
211.22g/mol
Molar mass
211.2150g/mol
Density
1.6200g/cm3
Appearence

Zalcitabine appears as a white crystalline powder.

Comment on solubility

Solubility of 5-ethyl-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione

The solubility of the compound 5-ethyl-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione (C9H13N3O4) is quite interesting, as it demonstrates unique properties influenced by its complex structure. Several factors play a role in its solubility:

  • Polarity: Due to the presence of multiple hydroxyl groups, this compound is likely to exhibit polar characteristics, which can enhance its solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl (–OH) groups facilitate hydrogen bonding with solvents, potentially increasing solubility in aqueous solutions.
  • Structural Configuration: The tetrahydrofuran moiety introduces a cyclic structure, which may contribute to the overall solubility profile in organic solvents.
  • Influence of Ethyl Group: The ethyl substituent can create steric hindrance that might affect interactions with solvents, further complicating the solubility behavior.

In summary, while 5-ethyl-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione is anticipated to be soluble in polar solvents, the precise solubility will depend on the balance between its polar and non-polar characteristics. As a result:

"The intricacies of solubility reflect the delicate balance of molecular interactions."

Understanding the solubility of this compound is essential for its applications in various fields, including pharmaceuticals and biochemical research.

Interesting facts

Exploring 5-Ethyl-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione

5-Ethyl-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione is a fascinating compound with notable biochemical relevance. It falls under the category of pyrimidine derivatives, which are integral in various biological processes.

Key Features:

  • Biological Significance: This compound shows potential as a precursor for nucleotides and nucleic acids, crucial for DNA and RNA synthesis.
  • Structural Intricacy: Its unique structure incorporates a tetrahydrofuran ring, which enhances stability and reactivity, making it a point of interest in medicinal chemistry.
  • Synthetic Routes: The synthesis of this compound involves intricate multi-step processes, showcasing the creativity and challenges faced by organic chemists.
  • Pharmacological Potential: Research suggests that derivatives of this class could exhibit promising pharmacological activities, including antioxidant and anti-inflammatory properties.

As Richard Feynman once said, "The imagination of nature is far greater than the imagination of man." This compound exemplifies this notion, revealing the complex interplay of functional groups in organic chemistry and their potential applications in pharmaceuticals. Its study not only enriches our understanding of chemical interactions but also opens avenues for innovative therapeutic strategies.

In summary, 5-Ethyl-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione is a remarkable compound worthy of further exploration due to its structural complexity and biological relevance.

Synonyms
EUDR
1-(2-deoxypentofuranosyl)-5-ethylpyrimidine-2,4(1h,3h)-dione
Edurid (Salt/Mix)
.beta.-5-Ethyldeoxyuridine
TimTec1_004024
SCHEMBL65580
MLS001360450
DTXSID70860153
.beta.-5-Ethyl-2'-deoxyuridine
XACKNLSZYYIACO-UHFFFAOYSA-N
HMS1545G20
HMS3056J10
HMS3369L22
5-Ethyl-2'-deoxyuridine ; Edoxudine
AKOS024282522
5-ethyl-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-dihydropyrimidine-2,4-d ione
SMR001223874
5-Ethyl-1-(2'-Deoxy-.beta.-D-ribofuranosyl)uracil