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Zebularine

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Identification
Molecular formula
C9H12N2O4
CAS number
3690-10-6
IUPAC name
5-ethyl-1-[4-hydroxy-3-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione
State
State

Zebularine is a solid at room temperature. It is often supplied as a fine crystalline powder that is stable under normal conditions. Being hygroscopic, care should be taken to store it in a dry environment.

Melting point (Celsius)
205.00
Melting point (Kelvin)
478.15
Boiling point (Celsius)
660.00
Boiling point (Kelvin)
933.15
General information
Molecular weight
212.19g/mol
Molar mass
212.1870g/mol
Density
1.6373g/cm3
Appearence

Zebularine appears as a white to off-white crystalline powder. It is hygroscopic, meaning it can absorb moisture from the environment.

Comment on solubility

Solubility of 5-ethyl-1-[4-hydroxy-3-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione

The solubility of a compound is a pivotal characteristic that determines its behavior in various environments, and for 5-ethyl-1-[4-hydroxy-3-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione (C9H12N2O4), certain aspects are essential to consider:

  • Polarity: The presence of multiple hydroxyl groups in its structure suggests a degree of polarity, which may enhance its solubility in polar solvents, particularly water.
  • Hydrogen Bonding: The hydroxyl groups can engage in hydrogen bonding with water molecules, contributing positively to its solubility profile.
  • Structural Factors: Its complex structure may introduce steric hindrance, potentially affecting how well it dissolves in certain environments.

In summary, while the structural characteristics of 5-ethyl-1-[4-hydroxy-3-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione imply favorable solubility in polar solvents due to hydrogen bonding capabilities, actual solubility will depend on specific conditions such as temperature and the solvent used. As with many compounds, experimental data is crucial to provide a definitive understanding of its solubility behavior.

Interesting facts

Interesting Facts About 5-ethyl-1-[4-hydroxy-3-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione

This intriguing compound, with its complex name, reveals a variety of exciting features that capture the interest of both chemists and biochemists alike.

Key Insights

  • Biological Significance: Compounds such as this one often play crucial roles in biological processes. They may exhibit properties that influence cellular functions or serve as precursors to vital biomolecules.
  • Synthetic Applications: The synthetic pathways to create this compound can be quite informative for chemistry students, shedding light on multi-step synthesis processes and organic reactions.
  • Pharmaceutical Relevance: The structural motifs present in 5-ethyl-1-[4-hydroxy-3-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione are common in certain medications, potentially linking it to therapeutic activities.
  • Functional Groups: The presence of both hydroxyl and carbonyl groups suggests potential for hydrogen bonding and reactivity, which can be critical in organic chemistry and medicinal chemistry studies.

Chemistry in Nature

This compound may also be a part of natural products or derived from biological systems, making it a fascinating subject for research in natural product chemistry. Natural products often inspire synthetic chemists to replicate their complex structures to harness their beneficial properties.

In summary, 5-ethyl-1-[4-hydroxy-3-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione is not just a compound with a long name; it represents an intersection of organic chemistry, medicinal applications, and natural products, making it a valuable topic for study and exploration.

Synonyms
5-ethyl-1-[4-hydroxy-3-(hydroxymethyl)-2-oxolanyl]pyrimidine-2,4-dione
5-ethyl-1-[4-hydroxy-3-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
KBio2_005485
Spectrum_000009
Spectrum2_001960
Spectrum3_001569
Spectrum4_000869
Spectrum5_001002
BSPBio_003078
KBioGR_001537
KBioSS_000349
DivK1c_000465
SPECTRUM1503214
SPBio_002059
CHEMBL2138464
HMS501H07
KBio1_000465
KBio2_000349
KBio2_002917
KBio3_002578
CHEBI:110195
NINDS_000465
HMS1922I15
HMS2092N18
Pharmakon1600-01503214
NSC758405
AKOS030241111
CCG-213128
IDI1_000465
NCGC00095019-02
NCGC00095019-03
NCGC00178311-01
SBI-0051787.P002
AB00052327_02
SR-05000001551
SR-05000001551-1
BRD-A62505706-001-03-1
Q27189576