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5-Chloro-8-hydroxyquinoline

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Identification
Molecular formula
C9H6ClNO
CAS number
130-16-5
IUPAC name
5-chloroquinolin-8-ol
State
State

At room temperature, 5-Chloro-8-hydroxyquinoline is in a solid state, typically available as a crystalline powder.

Melting point (Celsius)
108.00
Melting point (Kelvin)
381.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
193.59g/mol
Molar mass
193.5930g/mol
Density
1.5160g/cm3
Appearence

5-Chloro-8-hydroxyquinoline appears as a pale yellow crystalline powder. Its hue may vary slightly depending on the purity and particle size. It is often used in its solid powdered form in various applications.

Comment on solubility

Solubility of 5-chloroquinolin-8-ol (C9H6ClNO)

The solubility of 5-chloroquinolin-8-ol is an intriguing aspect of this compound, particularly because it displays certain characteristics that impact its behavior in various environments. Here are some key points to consider regarding its solubility:

  • Polar vs Non-Polar Behavior: The presence of the chlorine atom and the hydroxyl group makes this compound partially polar, which can influence its capacity to dissolve in solvents.
  • Solvent Compatibility: 5-chloroquinolin-8-ol is generally soluble in organic solvents such as ethanol and methanol, but its solubility in water is limited due to the aromatic nature of the quinoline structure.
  • pH Dependency: The solubility may also vary with pH levels, as the hydroxyl group can interact with protons, affecting the overall ionic state of the compound.
  • Temperature Influence: Increased temperature often enhances solubility for many organic compounds, and 5-chloroquinolin-8-ol is no exception, potentially increasing its dissolution rate in hot solvents.

Overall, it is important to note that understanding the solubility of 5-chloroquinolin-8-ol is essential for its applications in pharmaceuticals and biochemical studies. The ability to manipulate conditions—such as solvent choice and temperature—can maximize its effectiveness in various chemical processes.

Interesting facts

Interesting Facts about 5-Chloroquinolin-8-ol

5-Chloroquinolin-8-ol is a fascinating compound that belongs to the class of quinoline derivatives. It has garnered attention due to its diverse applications in various fields, particularly in medicinal chemistry. Here are some intriguing insights about this compound:

  • Pharmacological Importance: This compound is noteworthy for its potential biological activity. Studies have indicated that it exhibits antibacterial properties, which makes it a candidate for developing new antibiotics.
  • Research Applications: It is frequently used as a building block in the synthesis of more complex molecules, contributing to the design of novel pharmaceuticals and agrochemicals.
  • Antimalarial Properties: The quinoline core, commonly found in antimalarial drugs, suggests that derivatives like 5-chloroquinolin-8-ol could offer insight into developing new treatments for malaria.
  • Diagnostic Value: This compound can also be utilized in fluorescence analytical techniques, serving as a valuable tool for detecting certain biomolecules.
  • Environmental Relevance: Some studies are exploring the role of quinoline compounds, including 5-chloroquinolin-8-ol, in environmental science, particularly in understanding water pollution and its remediation.

As a scientist or a student, one might appreciate the complexity and versatility of 5-chloroquinolin-8-ol. It serves as an excellent example of how a simple modification in chemical structure can lead to significant variations in biological activity and applications. This compound exemplifies the intersection of chemistry and medicine, showcasing the potential of synthetic chemistry to address real-world challenges.

"In science, there are no shortcuts to solutions; the path is often paved with the insights gained from understanding compounds like 5-chloroquinolin-8-ol."

Synonyms
5-CHLORO-8-HYDROXYQUINOLINE
130-16-5
5-Chloroquinolin-8-ol
Cloxiquine
cloxyquin
5-Chloro-8-quinolinol
8-Quinolinol, 5-chloro-
5-Chlorooxine
Dermofongin
Dermofungin
Chlorisept
Chloroxychinolin
Dermofongin A
5-Chloro-8-oxyquinoline
8-Hydroxy-5-chloroquinoline
Cloxiquina
Monochlorohydroxyquinoline
Cloxyquin [USAN]
5-Chlor-8-chinolinol
Cloxiquinum [INN-Latin]
Cloxiquina [INN-Spanish]
Cloxiquine [INN]
MFCD00006788
NSC 35083
5-Chloro-quinolin-8-ol
5-chloranylquinolin-8-ol
UNII-BPF36H1G6S
EINECS 204-978-1
BPF36H1G6S
NSC-35083
Cloxiquine (INN)
Cloxyquin (USAN)
BRN 0005289
DTXSID4045973
5-Chloro-8-quinolol
CLOXYQUIN [MI]
5-Chloro-quinoline-8-ol
CLOXIQUINE [MART.]
CLOXIQUINE [WHO-DD]
MLS002695956
DTXCID2025973
5-21-03-00279 (Beilstein Handbook Reference)
NSC35083
NCGC00095303-02
SMR000274338
Cloxiquine 100 microg/mL in Acetonitrile
Cloxiquinum (INN-Latin)
Cloxiquina (INN-Spanish)
CLOXIQUINE (MART.)
quinoline, 5-chloro-8-hydroxy-
Cloxiquinum
CAS-130-16-5
cloxiquin
Dermofungin|
5-Chloroquinophenol
HZQ
Spectrum_000820
Spectrum2_001131
Spectrum3_000361
Spectrum4_000297
Spectrum5_000785
5Chloro-8-hydroxyquinoline
cid_2817
NCIOpen2_004102
Oprea1_189008
BSPBio_002081
KBioGR_000854
KBioSS_001300
5-chloro-8-hydroxy-quinoline
DivK1c_000163
SCHEMBL115838
SPECTRUM1500202
SPBio_001021
CHEMBL225164
5-Chloro-8-quinolinol, 95%
BCBcMAP01_000058
BDBM76305
HMS500I05
KBio1_000163
KBio2_001300
KBio2_003868
KBio2_006436
KBio3_001301
CHEBI:134818
NINDS_000163
HMS1920A06
HMS2091G14
HMS3091A16
Pharmakon1600-01500202
HY-B0963
NSC53182
STR00716
Tox21_111501
AC8858
CCG-39556
NSC-53182
NSC756701
s4559
STK015543
AKOS000121487
Tox21_111501_1
AC-4776
CS-4448
FC40563
NSC-756701
PS-3329
IDI1_000163
QTL1_000025
NCGC00095303-01
NCGC00095303-03
NCGC00095303-04
SY047042
SBI-0051320.P003
DB-041946
NS00009640
EN300-21587
D03572
AB00051952_05
CS-001/03840010
SR-05000002034
SR-05000002034-1
BRD-K46982791-001-02-9
BRD-K46982791-001-04-5
BRD-K46982791-001-09-4
Q27274791
F0001-0401
Z1954804579