Interesting facts
Interesting Facts about 5-chloro-N-(2-chloro-4-nitro-phenyl)-2-hydroxy-benzamide
This compound, commonly known in the realm of organic chemistry and pharmacology, is a fascinating example of a halogenated aromatic amide. It showcases intricate structural features due to the presence of both chlorine and nitro substituents, which significantly influence its chemical behavior and biological activity.
Chemical Versatility
- Reactivity: The presence of chlorine and nitro groups can enhance the compound's reactivity, making it suitable for various chemical transformations.
- Biological Activity: Compounds with similar structures are often investigated for their potential as pharmaceutical agents, given their ability to interact with biological targets.
Applications in Research
This compound serves as a valuable intermediate in the synthesis of more complex molecules. Researchers often explore its utility in:
- Synthesizing dyes and pigments.
- Studying interactions in biological systems, particularly in drug development.
Safety Considerations
While engaging with this compound, safety is paramount. Halogenated compounds can exhibit:
- Toxicity: Some halogenated aromatic compounds can be hazardous and require careful handling and disposal practices.
- Environmental Impact: The environmental persistence of similar compounds necessitates exploring greener alternatives or mitigation strategies during chemical synthesis.
Research Opportunities
The study of 5-chloro-N-(2-chloro-4-nitro-phenyl)-2-hydroxy-benzamide can pave the way for novel discoveries:
- Investigating structure-activity relationships (SAR) for potential drug candidates.
- Understanding mechanisms of action within specific biological pathways.
In summary, 5-chloro-N-(2-chloro-4-nitro-phenyl)-2-hydroxy-benzamide presents numerous avenues for exploration in chemical synthesis, pharmacology, and environmental sciences. Its unique structure and potential applications continue to captivate scientists in their quest for new knowledge.
Synonyms
niclosamide
50-65-7
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Niclocide
Bayluscid
Phenasal
Cestocid
Devermin
Devermine
Helmiantin
Mansonil
Radeverm
Tredemine
Vermitid
Atenase
Fenasal
Iomesan
Iomezan
Lintex
Nasemo
Sagimid
Sulqui
Yomesan
2',5-Dichloro-4'-nitrosalicylanilide
Mato
Fedal-Telmin
Zestocarp
Bayer 73
BAY 2353
Niclosamida
Bayer 2353
Chemagro 2353
C13H8Cl2N2O4
Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-
Niclosamidum
Niclosamide (anhydrous)
WR 46234
5-Chloro-2'-chloro-4'-nitrosalicylanilide
HL 2447
Nitrophenyl chlorsalicylamide
Niclosamide, anhydrous
ENT 25823
nicolsamide
CCRIS 3437
2-Hydroxy-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide
HSDB 1572
N-(2-Chloro-4-nitrophenyl)-5-chlorosalicylamide
2-Chloro-4-nitrophenylamide-6-chlorosalicylic acid
SR 73
Niclosamidum [INN-Latin]
Salicylanilide, 2',5-dichloro-4'-nitro-
2',5-Dichlor-4'-nitro-salizylsaeureanilid
UNII-8KK8CQ2K8G
Niclosamida [INN-Spanish]
EINECS 200-056-8
8KK8CQ2K8G
NSC 178296
NSC-178296
BRN 2820605
Niclosamide Anhydrous
Niclosamidum anhydrous
5-Chloro-N-(2'-chloro-4'-nitrophenyl)salicylamide
AI3-25823
5-Chlorosalicyloyl-(o-chloro-p-nitranilide)
BAY-2353
B 2353
MFCD00057597
N-(2'-Chlor-4'-nitrophenyl)-5-chlorsalicylamid
CHEBI:7553
DTXSID7040362
Radewerm
N-(2'-Chloro-4'-nitrophenyl)-5-chlorosalicylamide
CAS-50-65-7
NCGC00015735-07
Niclosamide 100 microg/mL in Acetonitrile
VU0243604
Niclosamidum (INN-Latin)
Niclosamida (INN-Spanish)
NICLOSAMIDE (MART.)
NICLOSAMIDE [MART.]
DTXCID5020362
Cestocide
NICLOSAMIDE (EP MONOGRAPH)
NICLOSAMIDE [EP MONOGRAPH]
Niclosamide [ISO]
Niclosamide [USAN:INN:BAN]
NICLOSAMIDE, ANHYDROUS (EP IMPURITY)
NICLOSAMIDE, ANHYDROUS [EP IMPURITY]
SR-01000076024
Niclosamide [BSI:ISO]
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamide
Utosamide
Yomensan
niclo-samide
Niclocide (TN)
Prestwick_354
Niclosamide (GMP)
2',5-Dichlor-4'-nitro-salizylsaeureanilid [German]
Mollutox (Salt/Mix)
N-(2'-Chlor-4'-nitrophenyl)-5-chlorsalicylamid [German]
Niclosamide (Standard)
Spectrum_000239
Niclosamide (Niclocide)
Clonitralid (Salt/Mix)
Clonitralide (Salt/Mix)
NICLOSAMIDE [MI]
Prestwick0_000040
Prestwick1_000040
Prestwick2_000040
Prestwick3_000040
Spectrum2_001183
Spectrum3_000667
Spectrum4_000196
Spectrum5_001083
Lopac-N-3510
NICLOSAMIDE [INN]
Niclosamide (USAN/INN)
NICLOSAMIDE [HSDB]
NICLOSAMIDE [USAN]
NICLOSAMIDE [VANDF]
CHEMBL1448
Lopac0_000866
Oprea1_259151
SCHEMBL67182
BSPBio_000139
BSPBio_002333
KBioGR_000771
KBioSS_000719
NICLOSAMIDE [WHO-DD]
MLS002154181
DivK1c_000709
SPECTRUM1503265
SPBio_001225
SPBio_002060
BPBio1_000153
GTPL8494
NICLOSAMIDE [GREEN BOOK]
SCHEMBL18563900
WLN: WNR CG DMVR BQ EG
BDBM11242
HMS502D11
HY-B0497G
HY-B0497R
KBio1_000709
KBio2_000719
KBio2_003287
KBio2_005855
KBio3_001553
5-Chloro-N-(2-chloro-4-nitro-phenyl)-2-hydroxy-benzamide
Niclosamide - CAS 50-65-7
NICLOSAMIDE [ORANGE BOOK]
P02DA01
NINDS_000709
BDBM513089
HMS1568G21
HMS2093A21
HMS2095G21
HMS2231H06
HMS3262N13
HMS3373P08
HMS3712G21
KUC107299N
Pharmakon1600-01503265
BCP22958
HY-B0497
Tox21_110209
Tox21_300749
Tox21_500866
BBL004110
CCG-39641
HB1435
NSC178296
NSC758440
s3030
Salicylanilide,5-dichloro-4'-nitro-
STK396676
2,5-dichloro-4-nitrosalicylanilide ?
AKOS003589004
NICLOSAMIDE ANHYDROUS [WHO-IP]
Tox21_110209_1
AT15436
BCP9000068
DB06803
FN01544
KS-5210
LP00866
NSC-758440
SB19414
SDCCGSBI-0050841.P004
2',5'-Dichloro-4'-nitrosalicylanilide
IDI1_000709
SMP2_000228
5-chloro-N-(2-chloro-4-nitrophenyl)-
NCGC00015735-01
NCGC00015735-02
NCGC00015735-03
NCGC00015735-04
NCGC00015735-05
NCGC00015735-06
NCGC00015735-08
NCGC00015735-09
NCGC00015735-11
NCGC00015735-12
NCGC00015735-17
NCGC00015735-21
NCGC00015735-24
NCGC00094190-01
NCGC00094190-02
NCGC00094190-03
NCGC00094190-04
NCGC00254654-01
NCGC00261551-01
KSC-18-157-2
SMR000058390
SBI-0050841.P003
DB-051812
AB00052340
EU-0100866
NICLOSAMIDUM ANHYDROUS [WHO-IP LATIN]
NS00000613
2',5-dichloro-2-hydroxy-4'-nitrobenzanilide
EN300-92958
D00436
N 3510
AB00052340_08
AB00052340_09
A828227
Q418523
SR-01000076024-1
SR-01000076024-3
SR-01000076024-6
BRD-K35960502-001-06-9
BRD-K35960502-001-11-9
BRD-K35960502-001-19-2
BRD-K35960502-001-20-0
Z57902203
5-Chloro-N-(2-chloro-4-nitrophenyl) -2-hydroxybenzamide
5-chloranyl-N-(2-chloranyl-4-nitro-phenyl)-2-oxidanyl-benzamide
Niclosamide (anhydrous), European Pharmacopoeia (EP) Reference Standard
200-056-8
VUT
Solubility of 5-chloro-N-(2-chloro-4-nitro-phenyl)-2-hydroxy-benzamide
The solubility of 5-chloro-N-(2-chloro-4-nitro-phenyl)-2-hydroxy-benzamide (C13H8Cl2N2O4) can be influenced by several factors due to its complex nature.
Factors Affecting Solubility
It is noteworthy that compounds with multiple halogens and functional groups often exhibit limited solubility in non-polar solvents. Conversely, they may dissolve better in organic solvents that can interact with their functional groups.
Solubility Trends
Generally, compounds such as this one can show:
In conclusion, the solubility of 5-chloro-N-(2-chloro-4-nitro-phenyl)-2-hydroxy-benzamide reflects a balance between its functional groups and molecular interactions within various solvents. Understanding these interactions is crucial for practical applications in chemical formulations and drug design.