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5-Chloro-3H-1,3-benzoxazol-2-one

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Identification
Molecular formula
C7H4ClNO2
CAS number
135-88-6
IUPAC name
5-chloro-3H-1,3-benzoxazol-2-one
State
State

This compound is a solid at room temperature.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.15
Boiling point (Celsius)
284.00
Boiling point (Kelvin)
557.15
General information
Molecular weight
169.57g/mol
Molar mass
169.5510g/mol
Density
1.5400g/cm3
Appearence

5-Chloro-3H-1,3-benzoxazol-2-one appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 5-chloro-3H-1,3-benzoxazol-2-one (C7H4ClNO2)

The solubility of 5-chloro-3H-1,3-benzoxazol-2-one can be quite intriguing due to its structural properties. Here are some key points to consider:

  • Polarity: The presence of the chlorine atom and the carbonyl group can contribute to the compound's overall polarity, affecting its interactions with solvents.
  • Solvent Compatibility: It is generally more soluble in organic solvents like ethanol and dichloromethane than in water due to its aromatic nature.
  • Temperature Influence: Like many organic compounds, solubility can increase with temperature, enhancing the ability of the solute to interact with solvent molecules.

In conclusion, while 5-chloro-3H-1,3-benzoxazol-2-one exhibits limited water solubility, it demonstrates a significant affinity for certain organic solvents. Understanding these solubility characteristics is crucial for applications in various chemical processes and research studies.

Interesting facts

Interesting Facts about 5-chloro-3H-1,3-benzoxazol-2-one

5-chloro-3H-1,3-benzoxazol-2-one is a fascinating compound with unique properties and applications that pique the interest of both chemists and biologists. Here are some noteworthy aspects of this compound:

  • Structural Features: The compound features a benzoxazole ring, which is notable for its aromatic characteristics and flexibility in forming hydrogen bonds. This ring structure gives rise to interesting reactivity patterns.
  • Biological Relevance: Compounds like 5-chloro-3H-1,3-benzoxazol-2-one are often studied for their biological activity. They can exhibit antimicrobial or anti-inflammatory properties, making them subjects of interest in medicinal chemistry.
  • Photochemical Applications: Due to its distinct chromophore, this compound can be utilized in photochemical reactions, which are essential in developing new materials and light-activated compounds.
  • Synthesis Versatility: The synthesis of benzoxazole derivatives can be achieved through various methods, including cyclization reactions and condensation processes, providing synthetic chemists with flexibility in laboratory settings.
  • Research Potential: As a member of the benzoxazole class, 5-chloro-3H-1,3-benzoxazol-2-one opens doors for further research into its derivatives, which could lead to discovering novel agents for pharmaceuticals and agrochemicals.

In summary, 5-chloro-3H-1,3-benzoxazol-2-one is not just a simple chemical compound; it is a promising structure in the field of chemical and biological research that may lead to exciting innovations. The exploration of its properties and applications continues to be a valuable endeavor for scientists worldwide.

Synonyms
chlorzoxazone
95-25-0
Chloroxazone
Paraflex
5-Chloro-2-benzoxazolone
Chlorzoxazon
5-Chloro-2(3H)-benzoxazolone
5-Chloro-2-benzoxazolinone
Biomioran
Myoflexin
Myoflexine
Pathorysin
Escoflex
Miotran
Neoflex
Solaxin
Mioran
5-Chloro-2-hydroxybenzoxazole
5-Chlorobenzoxazolidone
2(3H)-Benzoxazolone, 5-chloro-
5-Chloro-2-benzoxazolol
Parafon Forte DSC
5-Chlorobenzo[d]oxazol-2(3H)-one
Chlorzoxane
Strifon Forte Dsc
Usaf ma-10
5-Chlorobenzoxazol-2-one
5-Chlorobenzoxazolone
5-Chloro-1,3-benzoxazol-2(3H)-one
2-Hydroxy-5-chlorobenzoxazole
5-chloro-3H-1,3-benzoxazol-2-one
Chlorsoxazone
Chlorzoxazonum
Clorzoxazona
Klorzoxazon
Nyoflex
Parafon
Remofleks
5-Chlorbenzoxazolin-2-on
5-Chloro-3(H)-2-benzoxazolone
5-Chlorobenzoksazolon-2
5-Chlorobenzoksazolinon-2
chlorzoxazona
Lorzone
Strifon
5-chlorobenzoxazolin-2-one
5-chlorobenzo[d]oxazol-2-ol
Chlorzoxazonum [INN-Latin]
Clorzoxazona [INN-Spanish]
NSC 26189
2-BENZOXAZOLINONE, 5-CHLORO-
5-chloro-3H-benzooxazol-2-one
5-chloro-1,3-benzoxazol-2-ol
EINECS 202-403-9
UNII-H0DE420U8G
MFCD00005717
CHEBI:3655
H0DE420U8G
DTXSID9022813
AI3-63119
CHEMBL1371
MLS000069380
DTXCID302813
5-chloro-2,3-dihydro-1,3-benzoxazol-2-one
Parafon Forte
Chlorzoxazone [USP:INN:BAN:JAN]
NSC26189
NSC-26189
CAS-95-25-0
NCGC00015238-02
SMR000058269
Chlorzoxazonum (INN-Latin)
Clorzoxazona (INN-Spanish)
CLW
CHLORZOXAZONE (MART.)
CHLORZOXAZONE [MART.]
CHLORZOXAZONE (USP-RS)
CHLORZOXAZONE [USP-RS]
Chlorzoxazone (USP:INN:BAN:JAN)
CHLORZOXAZONE (USP IMPURITY)
CHLORZOXAZONE [USP IMPURITY]
CHLORZOXAZONE (USP MONOGRAPH)
CHLORZOXAZONE [USP MONOGRAPH]
5-Chlorobenzoksazolon-2 [Polish]
5-Chlorobenzoksazolinon-2 [Polish]
Paraflex (TN)
SR-01000075207
component of Parafon Forte
chlorozoxazone
Clorzoxazone
Chlorzoxazone (JAN/USP/INN)
Parafon Dsc
Prestwick_62
Chlorzoxazone,(S)
5-Chlorobenzoxazolinone
Spectrum_000148
Chlorzoxazone (Standard)
Opera_ID_1659
Prestwick0_000163
Prestwick1_000163
Prestwick2_000163
Prestwick3_000163
Spectrum2_001149
Spectrum3_000350
Spectrum4_000287
Spectrum5_000745
Lopac-C-4397
CHLORZOXAZONE [MI]
C 4397
CHLORZOXAZONE [INN]
CHLORZOXAZONE [JAN]
5-Chloro-benzooxazol-2-ol
5-chloro-2-benzoxazolinoone
5-chloro-benzoxazolin-2-one
Lopac0_000253
SCHEMBL35177
BSPBio_000025
BSPBio_002019
CHLORZOXAZONE [VANDF]
KBioGR_000814
KBioSS_000628
WLN: T56 BMVOJ HG
DivK1c_000895
SPECTRUM1500188
SPBio_001077
SPBio_001946
CHLORZOXAZONE [WHO-DD]
BPBio1_000029
GTPL2322
HMS502M17
HY-B1462R
KBio1_000895
KBio2_000628
KBio2_003196
KBio2_005764
KBio3_001239
M03BB03
NINDS_000895
HMS1568B07
HMS1920O07
HMS2091E14
HMS2095B07
HMS2235I19
HMS3259I15
HMS3260D08
HMS3373P17
HMS3652K22
HMS3712B07
HMS3885N07
Pharmakon1600-01500188
CHLORZOXAZONE [ORANGE BOOK]
ALBB-012641
BCP07916
HY-B1462
STR00805
Tox21_110105
Tox21_500253
BDBM50290811
CCG-40323
NSC756693
s4155
STK071582
AKOS000404381
Tox21_110105_1
component of Parafon Forte (Salt/Mix)
CS-5155
DB00356
FC20416
HG-0202
LP00253
NC00499
NSC-756693
SDCCGSBI-0050241.P005
5-chloranyl-3H-1,3-benzoxazol-2-one
5-chloro-1,3-benzoxazole-2(3H)-one
IDI1_000895
Chlorzoxazone 1.0 mg/ml in Acetonitrile
NCGC00015238-01
NCGC00015238-03
NCGC00015238-04
NCGC00015238-05
NCGC00015238-06
NCGC00015238-07
NCGC00015238-08
NCGC00015238-09
NCGC00015238-10
NCGC00015238-13
NCGC00015238-24
NCGC00093714-01
NCGC00093714-02
NCGC00093714-03
NCGC00093714-04
NCGC00260938-01
5-Chloro-1,3-benzoxazol-2(3H)-one #
AC-12192
BP-11613
SBI-0050241.P004
DB-057571
AB00051947
C2237
EU-0100253
NS00001077
SW196377-3
EN300-31026
C07931
D00771
D78096
AB00051947_05
AB00051947_06
A845253
Q3294630
SR-01000075207-1
SR-01000075207-3
SR-01000075207-5
BRD-K98174813-001-05-7
BRD-K98174813-001-08-1
BRD-K98174813-001-17-2
BRD-K98174813-001-18-0
Z57183224
5-Chloro-2(3H)-benzoxazolone;5-Chloro-2-benzoxazolol;Paraflex
Chlorzoxazone, United States Pharmacopeia (USP) Reference Standard
InChI=1/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10
202-403-9