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5-Bromopicolinamide

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Identification
Molecular formula
C6H5BrN2O
CAS number
5428-83-9
IUPAC name
5-bromopyridine-3-carboxamide
State
State

5-Bromopicolinamide is a solid at room temperature. It is commonly found in the form of crystalline powder, which indicates its solid aromatic structure typical for this type of compound.

Melting point (Celsius)
143.00
Melting point (Kelvin)
416.15
Boiling point (Celsius)
297.00
Boiling point (Kelvin)
570.15
General information
Molecular weight
201.03g/mol
Molar mass
201.0330g/mol
Density
1.7980g/cm3
Appearence

5-Bromopicolinamide is a crystalline solid that can appear as white to off-white crystals or powder. Its appearance is typical of many organic compounds that contain halogenated benzene rings coupled with amide groups, which contribute to its solid state and crystalline structure.

Comment on solubility

Solubility of 5-bromopyridine-3-carboxamide (C6H5BrN2O)

5-bromopyridine-3-carboxamide is a compound that exhibits interesting solubility properties due to its chemical structure. Strong hydrogen bonding interactions and its polar nature contribute to its solubility characteristics.

Solubility Characteristics:

  • Polar Solvents: This compound is expected to be soluble in polar solvents, such as water and alcohols. The presence of the carboxamide functional group enhances its ability to interact with polar molecules.
  • Non-Polar Solvents: It is likely to have limited solubility in non-polar solvents, as its polar regions do not favor interactions with non-polar entities.
  • Temperature Effects: Solubility might increase with temperature, a common trend for many organic compounds.

In summary, the solubility of 5-bromopyridine-3-carboxamide can be classified predominantly as moderate to high in polar solvents while being low in non-polar media. This makes it a versatile compound for various chemical applications, particularly in polar environments.

Interesting facts

Interesting Facts About 5-Bromopyridine-3-carboxamide

5-Bromopyridine-3-carboxamide is a fascinating compound, particularly noted for its utility in various fields of chemistry and medicinal applications. Below are some intriguing aspects of this compound:

  • Pyridine Derivative: As a member of the pyridine family, this compound features a nitrogen atom in its aromatic ring, which enhances its chemical reactivity and versatility.
  • Range of Applications: 5-Bromopyridine-3-carboxamide serves as a building block for numerous pharmaceuticals, agrochemicals, and fine chemicals, illustrating its importance in industrial chemistry.
  • Functional Groups: The presence of both a bromine atom and a carboxamide group lends this compound unique properties, making it an interesting subject for scientists exploring nucleophilic substitutions and other reactions.
  • Reactivity Insight: The bromine atom attached to the pyridine ring is known to enhance the electrophilicity of the adjacent functional groups, thereby influencing reaction pathways significantly.
  • Biological Relevance: Compounds analogous to 5-bromopyridine-3-carboxamide have shown potential in the design of inhibitors for various biological targets, making them crucial in drug discovery.

Overall, 5-bromopyridine-3-carboxamide stands out due to its structural features and myriad functional implications, making it a valuable compound in both research and application in chemistry. As the field of synthetic and medicinal chemistry continues to evolve, the importance of such compounds is only expected to grow.

Synonyms
5-bromonicotinamide
28733-43-9
5-Bromo-3-pyridinecarboxamide
5-bromopyridine-3-carboxamide
3-Pyridinecarboxamide, 5-bromo-
Nicotinamide, 5-bromo-
FCT9J0CUP7
BRN 0115921
UNII-FCT9J0CUP7
MFCD00173919
DTXSID00182890
5-22-02-00182 (Beilstein Handbook Reference)
5-Bromo-nicotinamide
3-Bromo-5-carbamoylpyridine
BRT
SCHEMBL578591
5-bromo-3-pyridinylcarboxamide
5-bromo-pyridine-3-carboxamide
DTXCID40105381
HMS3604K17
BCP27010
STL503460
5-Bromo-3-pyridinecarboxamide, 97%
AKOS000114022
CS-W015578
DB01854
FS-2677
3-Pyridinecarboxamide, 5-bromo-(9CI)
PD008723
SY001775
DB-013112
B3536
NS00068205
EN300-1232895
AC-907/30003011
AJ-333/25006337
Q27092981
Z33546660
F2124-0064
626-875-4