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5-aminoisoquinolin-1-one

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Identification
Molecular formula
C9H8N2O
CAS number
1511-69-7
IUPAC name
5-amino-2H-isoquinolin-1-one
State
State

At room temperature, 5-aminoisoquinolin-1-one is generally found in a solid state. It is characterized by its crystalline structure which is stable under standard laboratory conditions.

Melting point (Celsius)
200.00
Melting point (Kelvin)
473.15
Boiling point (Celsius)
379.00
Boiling point (Kelvin)
652.15
General information
Molecular weight
160.17g/mol
Molar mass
160.1650g/mol
Density
1.2940g/cm3
Appearence

5-aminoisoquinolin-1-one typically presents as a crystalline solid. The compound can appear as off-white to pale yellow crystals, depending on its purity and form. It may exhibit luminescent properties under certain conditions, which are of interest in various chemical analyses and applications.

Comment on solubility

Solubility of 5-amino-2H-isoquinolin-1-one (C9H8N2O)

The solubility of 5-amino-2H-isoquinolin-1-one is an interesting aspect of its chemical behavior, influenced by various factors. This compound can typically be described as:

  • Moderately Soluble: It shows moderate solubility in polar solvents, likely due to its hydrogen bond capacity provided by both the amino group and the carbonyl.
  • Water Solubility: The solubility in water is limited, often requiring the use of organic solvents for effective dissolution.
  • Influencing Factors: Factors such as pH, temperature, and the presence of other solutes can significantly impact its solubility. For instance, increasing temperature might enhance solubility.

In practice, when working with 5-amino-2H-isoquinolin-1-one, one might encounter the following general observations:

  • The compound is frequently employed in organic synthesis and can be dissolved in solvents like ethanol, which facilitates its reaction with various reagents.
  • In biological contexts, its limited solubility might restrict its bioavailability, making formulations critical for therapeutic applications.
  • The solubility tends to vary based on specific substitutes on the isoquinolinone scaffold, leading to nuanced variations in solubility profiles.

In essence, understanding the solubility of 5-amino-2H-isoquinolin-1-one is vital for its effective application across chemical research and pharmacological development.

Interesting facts

Interesting Facts about 5-Amino-2H-isoquinolin-1-one

5-Amino-2H-isoquinolin-1-one is a fascinating compound with a variety of applications and implications in the field of organic chemistry and pharmaceuticals. Here are some intriguing aspects of this compound:

  • Structural Significance: The structure of 5-amino-2H-isoquinolin-1-one includes a fused ring system, characteristic of isoquinolines, which contributes to its biological activity. The presence of both an amino group and a carbonyl group on the isoquinoline structure enhances its reactivity.
  • Biological Activity: This compound has shown potential in various biological applications. It is under investigation for its role as a pharmacophore in several drugs, including those that exhibit anti-cancer and anti-inflammatory properties. Studies have indicated that it has the ability to inhibit specific enzymes that contribute to disease pathways.
  • Synthetic Pathways: The synthesis of 5-amino-2H-isoquinolin-1-one can be achieved through several methods, often involving cyclization reactions. Chemists frequently explore these synthetic routes to optimize yield and reduce environmental impact.
  • Research Applications: Due to its unique chemical properties, 5-amino-2H-isoquinolin-1-one is a valuable intermediate in the synthesis of more complex compounds. It serves as a building block for the development of novel pharmaceutical agents.
  • Lasting Impact: The study of this compound contributes significantly to our understanding of heterocyclic chemistry, paving the way for innovations in drug design and development. As researchers continue to explore its potential, the compound remains a subject of interest within the scientific community.

In summary, 5-amino-2H-isoquinolin-1-one exemplifies the intersection of organic synthesis and medicinal chemistry, highlighting how even seemingly simple structures can have profound implications in health and science. As the research around this compound unfolds, it's exciting to think about what future discoveries may emerge.

Synonyms
5-aminoisoquinolin-1(2H)-one
93117-08-9
5-amino-2H-isoquinolin-1-one
5-AMINOISOQUINOLIN-1-OL
5-AIQ
5-Amino-2H-isoquinoin-1-one
5-amino-1,2-dihydroisoquinolin-1-one
MFCD06198896
5-AMINO-1(2H)-ISOQUINOLINONE
CHEMBL446240
DTXSID90274354
5-aminoisoquinolinone
4pnq
32X
1(2H)-ISOQUINOLINONE, 5-AMINO-
8V3G4R3QNX
SCHEMBL215327
5-Azanyl-2H-isoquinolin-1-one
5-amino isoquinolin-1(2h)-one
5-amino-isoquinolin-1(2h)-one
BDBM27503
1(2H)-Isoquinolinone,5-amino-
DTXCID20225834
CHEBI:103965
SVASVGVAQIVSEZ-UHFFFAOYSA-N
CL1034
HSCI1_000395
MFCD11226760
AKOS006334830
AKOS015855680
CS-W006566
GS-6691
HY-W006566
PB32405
NCGC00165729-01
AC-20662
BL006316
PD120846
SY033479
DB-079484
EN300-247183
BRD-K25408656-003-01-2
Q27181199
5-Amino-1(2H)-isoquinolinone; 5-Amino-isocarbostyril;
Z2236664363
801-002-1