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Tobramycin

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Identification
Molecular formula
C18H37N5O9
CAS number
32986-56-4
IUPAC name
5-amino-2-[[7-amino-6-(4,6-diamino-2,3-dihydroxy-cyclohexoxy)-4-hydroxy-3-(methylamino)-2,3,4,4a,6,7,8,8a-octahydropyrano[3,2-b]pyran-2-yl]oxy]-6-(hydroxymethyl)-2-methyl-tetrahydropyran-3,4-diol
State
State

At room temperature, Tobramycin typically exists in solid form as a powder. It is stable under normal conditions of use and storage but it is hygroscopic and should be kept in airtight containers.

Melting point (Celsius)
298.00
Melting point (Kelvin)
571.15
Boiling point (Celsius)
407.10
Boiling point (Kelvin)
680.25
General information
Molecular weight
467.51g/mol
Molar mass
467.5110g/mol
Density
1.3600g/cm3
Appearence

Tobramycin is a white to off-white powder. It is often supplied as a sulfate salt that appears crystalline in form, suitable for pharmaceutical preparations, particularly in eye drops or inhalation solutions.

Comment on solubility

Solubility of 5-amino-2-[[7-amino-6-(4,6-diamino-2,3-dihydroxy-cyclohexoxy)-4-hydroxy-3-(methylamino)-2,3,4,4a,6,7,8,8a-octahydropyrano[3,2-b]pyran-2-yl]oxy]-6-(hydroxymethyl)-2-methyl-tetrahydropyran-3,4-diol

The solubility characteristics of this complex compound, represented by the formula C18H37N5O9, are intriguing due to its dense structure and multiple functional groups.

Factors influencing its solubility include:

  • Presence of Hydroxyl Groups: The multiple hydroxyl groups (-OH) in its structure enhance its solubility in polar solvents such as water.
  • Amine Functionalities: The amino groups contribute to hydrogen bonding, further increasing solubility in aqueous environments.
  • Structural Complexity: The presence of cyclohexoxy and pyran structures may impart some hydrophobic character, potentially affecting solubility in organic solvents.

Generally, this compound is expected to be:

  • Relatively soluble in water due to its numerous hydrophilic groups.
  • Less soluble in nonpolar solvents because of its polar functionalities.

To summarize, the solubility of 5-amino-2-[[7-amino-6-(4,6-diamino-2,3-dihydroxy-cyclohexoxy)-4-hydroxy-3-(methylamino)-2,3,4,4a,6,7,8,8a-octahydropyrano[3,2-b]pyran-2-yl]oxy]-6-(hydroxymethyl)-2-methyl-tetrahydropyran-3,4-diol largely depends on its balance of hydrophilic and hydrophobic characteristics, making it a compound of interest in solubility studies.

Interesting facts

Interesting Facts about 5-amino-2-[[7-amino-6-(4,6-diamino-2,3-dihydroxy-cyclohexoxy)-4-hydroxy-3-(methylamino)-2,3,4,4a,6,7,8,8a-octahydropyrano[3,2-b]pyran-2-yl]oxy]-6-(hydroxymethyl)-2-methyl-tetrahydropyran-3,4-diol

This compound, known for its complex structure and multifunctional groups, is an interesting subject of study in the field of medicinal chemistry. Here are some engaging points about this compound:

  • Chemical Diversity: The molecule exhibits remarkable structural diversity, featuring multiple functional groups including amino, hydroxy, and oxymethyl groups, which play a crucial role in its biological activity.
  • Potential Applications: Due to its intricate configuration, this compound has potential applications in drug development, particularly in the search for new therapies targeting various diseases.
  • Mechanism of Action: Compounds resembling this have been found to interact with specific receptors in the body, which could lead to a better understanding of their mechanism of action and efficacy.
  • Natural Derivatives: Interestingly, many compounds with similar structures are derived from natural products, highlighting the connection between nature and synthetic chemistry.
  • Research Relevance: Ongoing studies aim to explore the efficacy, safety, and pharmacokinetics of this compound, paving the way for new findings in pharmacology.

As scientists continue to unravel the properties and potential of such complex molecules, the journey not only enhances our understanding of chemistry but also opens up new avenues for therapeutic innovations. "Chemistry is the art of solving the puzzles of nature," as they say, and compounds like this one are at the forefront of that artistic endeavor.