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Amodiaquine

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Identification
Molecular formula
C20H22ClN3O
CAS number
86-42-0
IUPAC name
5-[(7-chloro-4-quinolyl)amino]-2-(diethylaminomethyl)phenol
State
State

At room temperature, Amodiaquine is a solid. It is commonly used in its hydrochloride form, which is more stable for pharmaceutical use.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
665.00
Boiling point (Kelvin)
938.15
General information
Molecular weight
355.86g/mol
Molar mass
355.8840g/mol
Density
1.2000g/cm3
Appearence

Amodiaquine is typically a yellow crystalline solid when isolated in its pure form. The color can slightly vary depending on purity and the form of the salt if it’s being used in pharmaceutical preparations.

Comment on solubility

Solubility of 5-[(7-chloro-4-quinolyl)amino]-2-(diethylaminomethyl)phenol

The solubility of 5-[(7-chloro-4-quinolyl)amino]-2-(diethylaminomethyl)phenol (C20H22ClN3O) can be complex due to its unique structure and functional groups. Generally, solubility is influenced by several factors, including:

  • Polarity: Compounds with polar functional groups tend to be more soluble in polar solvents, while non-polar compounds are better suited for non-polar solvents.
  • Hydrogen bonding: The presence of amine and hydroxyl groups in the compound likely enhances its ability to form hydrogen bonds with water, potentially increasing its solubility in aqueous solutions.
  • Alkyl chain effects: The diethylamino moiety may impart some degree of hydrophobic character, which could limit solubility in highly polar solvents.

In summary, the solubility of this compound may vary depending on the solvent used. It is often observed that:

  • Higher solubility in alcoholic solvents due to compatible polarity.
  • Limited solubility in pure water but potentially increased with the addition of co-solvents.

As with many organic compounds, experimental approaches are essential for accurately determining solubility. Understanding the balance between hydrophilic and hydrophobic characteristics can provide insights into its behavior in different mediums. Hence, it's crucial to test various solvents to find the most suitable environment for dissolution.

Interesting facts

Interesting Facts About 5-[(7-chloro-4-quinolyl)amino]-2-(diethylaminomethyl)phenol

This intriguing compound, often abbreviated due to its complexity, boasts a rich biological profile that has garnered attention in pharmaceutical research. Here are some key points to consider:

  • Antimicrobial Properties: Research has indicated that compounds similar to this one exhibit promising antimicrobial activities. Their unique structure may interact with microbial cells, inhibiting growth.
  • Quinoline Derivatives: The presence of the quinoline moiety in the compound is well-known in medicinal chemistry for its ability to serve as an effective scaffold in creating new drug entities.
  • Applications: Its potential applications are manifold, ranging from antiparasitic agents to anticancer therapies. Investigating how modifications to the structure might enhance efficacy is a valuable pursuit.
  • Structure-Activity Relationship (SAR): Scientists are keenly interested in understanding how structural changes affect its biological activity, which is illustrated through various SAR studies where subtle modifications can lead to drastically different outcomes.
  • Research Frontier: As novel compounds in this class are examined, they raise important questions about how they can be harnessed therapeutically, making them a topic of ongoing research.

To quote a prominent researcher in the field, "The exploration of quinoline derivatives has revolutionized the approach to antibiotic development." This emphasizes the critical role of this compound in ongoing discussions concerning drug discovery.

Overall, 5-[(7-chloro-4-quinolyl)amino]-2-(diethylaminomethyl)phenol represents not just a chemical compound, but a stepping stone towards advancing our understanding of pharmacology and developing better therapeutic solutions.

Synonyms
ISOQUINE
1643-45-4
5-[(7-Chloro-4-quinolyl)amino]-2-[(diethylamino)methyl]phenol
5-((7-Chloroquinolin-4-yl)amino)-2-((diethylamino)methyl)phenol
MFCD00599415
CHEMBL147587
5-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol
5-[(7-Chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]phenol
NINDS_000687
Spectrum_000046
GKN7GKK6EY
Spectrum2_000768
Spectrum3_000299
Spectrum4_000147
Spectrum5_000808
BSPBio_001838
KBioGR_000594
KBioSS_000426
DivK1c_000687
SPBio_000816
SCHEMBL5836418
KBio1_000687
KBio2_000426
KBio2_002994
KBio2_005562
KBio3_001338
AC8916
BDBM50134931
Phenol, 5-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-
SB73030
IDI1_000687
NCGC00178968-01
SY261673
SBI-0051280.P003
DB-196269
AB00053418_02
5-((7-Chloranylquinolin-4-yl)-2-(diethylaminomethyl)phenol
5-(7-Chloro-quinolin-4-ylamino)-2-diethylaminomethyl-phenol
5-(7-chloroquinolin-4-ylamino)-2-((diethylamino)methyl)phenol
5-[(7-chloro-4-quinolyl)amino]-2-(diethylaminomethyl)phenol