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Tenofovir

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Identification
Molecular formula
C9H12N5O3P
CAS number
147127-20-6
IUPAC name
5-(6-aminopurin-9-yl)-N-cyclopropyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
State
State

At room temperature, tenofovir is typically in a solid state as a crystalline powder.

Melting point (Celsius)
279.90
Melting point (Kelvin)
553.05
Boiling point (Celsius)
600.00
Boiling point (Kelvin)
873.15
General information
Molecular weight
287.21g/mol
Molar mass
287.2130g/mol
Density
1.4900g/cm3
Appearence

Tenofovir appears as a white to off-white crystalline powder. It is generally odorless.

Comment on solubility

Solubility of 5-(6-aminopurin-9-yl)-N-cyclopropyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide

The solubility of the compound 5-(6-aminopurin-9-yl)-N-cyclopropyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide (C9H12N5O3P) can be influenced by several factors. Understanding its solubility characteristics is essential for predicting its behavior in various environments and applications. Here are some key points regarding its solubility:

  • Polarity: The presence of multiple hydroxyl groups and a carboxamide moiety contributes to a higher polarity, which generally enhances solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds with solvent molecules can significantly affect its solubility. Compounds capable of strong interactions with water tend to be more soluble.
  • Temperature: Solubility can be temperature-dependent; often, increasing the temperature can increase solubility in many cases.
  • pH Levels: The solubility of this compound may vary with changes in pH, especially due to the presence of the carboxamide, which can be protonated or deprotonated depending on the solution's acidity.

In conclusion, while specific solubility data for this compound may need to be investigated experimentally, its structural attributes suggest it may exhibit reasonable solubility in polar solvents, particularly under optimized conditions. As always, experimental verification is essential to confirm theoretical predictions.

Interesting facts

Interesting Facts about 5-(6-aminopurin-9-yl)-N-cyclopropyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide

This fascinating compound, often referred to as an analog of purine nucleosides, exhibits significant biological implications, particularly in the realm of medicinal chemistry. Its structural complexity and unique functional groups make it a compelling subject for research and study.

Biological Importance

  • Purine Analogs: The compound is an analog of essential nucleobases, which play a critical role in the composition of DNA and RNA. This similarity offers potential in understanding genetic mechanisms.
  • Potential Therapeutic Applications: Investigations into its pharmacological properties reveal potential applications in treating viral infections and cancers, where modulation of nucleic acid synthesis is crucial.
  • Enzyme Interaction: The compound may interact with specific enzymes, possibly acting as an inhibitor. This interaction could pave the way for novel therapeutic strategies designed to combat diseases.

Chemical Features

  • Cyclopropyl Group: The presence of the cyclopropyl moiety contributes to the compound's rigidity, which may enhance binding affinity to biological targets.
  • Hydroxyl Groups: The two hydroxyl groups introduce additional sites for hydrogen bonding, which may improve the compound's solubility and bioavailability.
  • Amino Group: The amino functional group may enhance the compound’s interaction with molecular receptors, offering insights into its potential as a drug candidate.

As researchers continue to explore the nuances of this compound, it stands as a testament to the intricate relationship between structure and function in medicinal chemistry. In the words of a leading chemist, "Understanding the details of these compounds can unlock new paths for innovation in therapy."

This compound exemplifies the exciting frontier of chemical research where molecular design strives to inform and enhance human health.

Synonyms
5'-(N-Cyclopropyl)carboxamidoadenosine
5'-(N-CYCLOPROPYL)-CARBOXAMIDOADENOSINE
REGID_for_CID_1761
MLS002153508
CHEMBL28449
(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-cyclopropyl-3,4-dihydroxyoxolane-2-carboxamide
HMS2235M15
HMS3372E17
ZINC00057265
5-(6-aminopurin-9-yl)-N-cyclopropyl-3,4-dihydroxyoxolane-2-carboxamide
PD045110
SMR001230840
DB-051862