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Tenofovir alafenamide

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Identification
Molecular formula
C21H29O5P
CAS number
379270-37-8
IUPAC name
[[[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]-difluoro-methyl]phosphonic acid
State
State

At room temperature, tenofovir alafenamide is typically found as a solid. It is stable under normal conditions and is handled as a solid crystalline powder in pharmaceutical formulations.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
377.20
Boiling point (Kelvin)
650.30
General information
Molecular weight
476.48g/mol
Molar mass
476.4820g/mol
Density
1.5000g/cm3
Appearence

Tenofovir alafenamide is a white to off-white solid powder. Its appearance can vary slightly depending on the form in which it is found. It is usually observed as a crystalline powder that is highly soluble in water.

Comment on solubility

Solubility of 5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]-difluoro-methyl]phosphonic acid

The compound C21H29O5P exhibits intriguing solubility characteristics that reflect its complex structure. Solubility is an essential property, influencing various applications in pharmaceuticals and biochemistry.

This compound's solubility can be affected by several factors:

  • Polarity: The presence of multiple hydroxyl (-OH) and phosphoryl (-PO4) groups increases the polarity of the molecule, potentially enhancing its solubility in polar solvents like water.
  • Concentration: At higher concentrations, solubility can be influenced by intermolecular interactions such as hydrogen bonding, which may either facilitate or hinder dissolution.
  • Temperature: In many cases, an increase in temperature can lead to increased solubility, as thermal energy assists the dissolution process.

As a general perspective, polar compounds such as this one often exhibit greater solubility in aqueous environments compared to nonpolar solvents. This property is crucial for biological systems, where solubility may directly affect bioavailability and interaction with biomolecules.

In summary, the solubility of this compound is likely influenced by its molecular structure and environmental conditions, making it a subject of interest for further research to unlock its potential applications.

Interesting facts

Interesting Facts About 5-(6-Aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl Methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl-difluoro-methyl Phosphonic Acid

This intricate compound, intriguingly named 5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl-difluoro-methyl phosphonic acid, embodies the fascinating world of medicinal chemistry and biochemical research. Here are some notable facts about it:

  • Role in Biochemistry: This compound is of significant interest in the study of nucleotides and nucleosides, especially related to nucleotide metabolism and their role in genetic expression.
  • Research Implications: The presence of aminopurine highlights its potential influence on various biological pathways, and it could be investigated for use in therapies against certain diseases, particularly those associated with cellular dysfunction.
  • Potential Analogues: Given its structure, it may serve as a scaffold for the design of new pharmaceuticals, allowing modifications to improve efficacy and selectivity in targeting specific biological molecules.
  • Phosphonic Acids: Compounds in this category often function as enzyme inhibitors, providing a possible mechanism to regulate metabolic pathways, thus presenting both challenges and opportunities in drug design.
  • Synthetic Challenges: The complexity of its synthesis may require advanced organic chemistry techniques, making it a favorite topic for discussion in synthetic methodology courses.

As a combination of various functional groups, this compound exemplifies how slight changes in molecular structure can lead to significant variations in biological activity, raising endless questions and possibilities for researchers in the field.
This compound truly represents the intricate dance between chemistry and biology!