Skip to main content

Thiamine Pyrophosphate

ADVERTISEMENT
Identification
Molecular formula
C12H19N4O7P2S
CAS number
154-87-0
IUPAC name
[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate
State
State

At room temperature, thiamine pyrophosphate is typically in a solid state. It is generally stable under standard conditions and should be stored in a dry environment to maintain its stability.

Melting point (Celsius)
240.00
Melting point (Kelvin)
513.15
Boiling point (Celsius)
200.00
Boiling point (Kelvin)
473.15
General information
Molecular weight
507.15g/mol
Molar mass
507.1460g/mol
Density
1.0450g/cm3
Appearence

Thiamine pyrophosphate is typically a white crystalline powder. It may also appear as a colorless substance and is odorless or has a faint characteristic odor typical of phosphate esters.

Comment on solubility

Solubility of the Compound

The solubility of the compound: [5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl [3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate with the chemical formula C12H19N4O7P2S is influenced by various factors related to its molecular structure.

Key Points on Solubility:

  • Polarity: The presence of polar functional groups such as hydroxyl (-OH) and phosphate (-PO4) moieties suggests that this compound may exhibit considerable solubility in polar solvents like water.
  • Hydrophobic Sections: Conversely, the compound also possesses hydrophobic segments due to its carbon and nitrogen framework, which could limit its solubility in strictly polar environments.
  • pH Sensitivity: The solubility can vary significantly depending on the pH of the solution. Acidic or basic conditions may lead to ionization of functional groups, affecting solubility.

Overall, the compound is expected to have:

  1. High solubility in polar solvents, particularly when the pH is within a suitable range.
  2. Variable solubility in non-polar solvents, likely leading to a lower solubility profile.

In conclusion, the solubility behavior of this compound is a compelling reflection of its intricate balance of polar and non-polar characteristics, allowing for versatile interactions in various chemical environments.

Interesting facts

Interesting Facts about [5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate

This compound is a complex and fascinating molecule that showcases the intricate interplay of organic chemistry and biochemistry. Here are some highlights that make it particularly interesting:

  • Dual Functionality: The compound contains two distinct functional units - a phosphoryl group, which is vital in energy transfer processes within biological systems, and aminopurine, a nucleobase that plays a pivotal role in genetic information.
  • Medicinal Potential: The structural composition suggests that this compound could have therapeutic applications, particularly in the fields of oncology and antiviral treatments. Its interactions with nucleic acids may offer unique avenues for drug development.
  • Biochemical Interaction: This molecule may mimic the structure of certain naturally occurring substrates, thereby potentially inhibiting or enhancing the activity of enzymes such as kinases, which are critical in signal transduction pathways.
  • Sulfur Element Role: The presence of sulfur in the molecule is particularly noteworthy, as sulfur-containing compounds can impart unique electronic properties and reactivity, impacting the compound's overall biological activity.
  • Research Interest: Academic and pharmaceutical research often investigates compounds like this for their ability to modify metabolic pathways, which might lead to new discoveries in drug design and personalized medicine.

In summary, the complexity of this compound reflects the rich diversity found in the molecular world – an intricate balance of chemistry that could hold solutions to some of today's pressing medical challenges. As a chemist, the study of such compounds can lead to exciting developments in understanding how small changes in structure can have significant impacts on biological activity.

Synonyms
3?-Dephosphocoenzyme A
SCHEMBL15362468
DTXSID20863235
3'-Dephosphocoenzyme A, >=90% (HPLC)
[5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl 3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl dihydrogen diphosphate