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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
201341-05-1
IUPAC name
[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] dihydroxyphosphinothioyl hydrogen phosphate
State
State

At room temperature, Tenofovir possesses a solid-state. It is generally handled in the form of its salt due to enhanced solubility and stability. The solid form ensures ease of formulation in pharmaceutical preparations.

Melting point (Celsius)
112.00
Melting point (Kelvin)
385.15
Boiling point (Celsius)
296.00
Boiling point (Kelvin)
569.15
General information
Molecular weight
287.21g/mol
Molar mass
287.2130g/mol
Density
1.4900g/cm3
Appearence

Tenofovir is a white to off-white crystalline solid. It is generally supplied in the form of its salt, tenofovir disoproxil fumarate, which is also white to off-white in appearance.

Comment on solubility

Solubility of the Compound

The solubility of the compound [5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl dihydroxyphosphinothioyl hydrogen phosphate (C9H14N5O4P)

is often a crucial factor influencing its applications in various scientific fields. Given its complex structure, the solubility can be affected by multiple factors:

  • Polarity: The presence of hydroxyl groups and phosphate moieties generally enhances polarity, making the compound more soluble in polar solvents like water.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds can significantly contribute to its solubility. Compounds with multiple hydroxyl groups often exhibit higher solubility in water due to favorable interactions with water molecules.
  • pH Sensitivity: The solubility might also vary with changes in pH, especially if the compound can donate or accept protons.
  • Temperature: Generally, increasing temperature can lead to higher solubility for many compounds, but this isn't universally applicable.

In summary, the solubility of this compound is likely to be influenced by its functional groups, structural complexity, and environmental conditions. It would be beneficial to conduct experimental solubility tests in various solvents to fully understand its solubility profile.

Interesting facts

Interesting Facts About [5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl dihydroxyphosphinothioyl hydrogen phosphate

This compound is a fascinating example of a multifunctional molecule that plays a crucial role in various biochemical processes. Its complex structure indicates that it could be a potential candidate for applications in pharmaceutical chemistry, particularly in drug design and delivery. Here are some intriguing aspects of this compound:

  • Structural Diversity: The presence of an aminopurine moiety suggests potential interactions with nucleic acids, making it relevant in biochemistry and molecular biology.
  • Functionality: The various functional groups in this compound indicate it may possess unique properties, enhancing its reactivity and interaction with biological targets.
  • Potential Therapeutic Use: Given its structure, this compound may be explored for therapeutic applications related to antiviral or anticancer treatments. Compounds with purine derivatives are often studied for their biological activity.
  • Phosphorus Chemistry: The incorporation of phosphorus in the molecular framework highlights the importance of phosphorous compounds in biological systems, particularly in energy transfer (as seen in ATP), signaling, and the structural integrity of nucleic acids.

This compound exemplifies a multi-functional approach in medicinal chemistry, where small modifications to the chemical structure can lead to significant changes in biological activity. As researchers continue to explore its properties, this compound holds promise for advancing our understanding of biochemical mechanisms and developing new therapeutic strategies.

Synonyms
ATP,Gamma S
SCHEMBL13996417
BDBM86479
CAS_440317
NSC_440317
Adenosine-5'-O-(1-thiotriphosphate) lithium salt - 100 mM aqueous solution
L000118