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Nicotinamide adenine dinucleotide phosphate

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Identification
Molecular formula
C21H29N7O17P3
CAS number
53-59-8
IUPAC name
[[5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate
State
State

At room temperature, nicotinamide adenine dinucleotide phosphate is typically found as a solid. In living organisms, it is dissolved and active mainly in the cytoplasm, functioning in various enzymatic reactions.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
765.43g/mol
Molar mass
765.4250g/mol
Density
2.8400g/cm3
Appearence

Nicotinamide adenine dinucleotide phosphate (NADP+) typically appears as a white to off-white powder when isolated. It is a coenzyme that exists in solution within biological cells, where it plays critical roles in metabolism. In its pure form, it is crystalline with no significant odor.

Comment on solubility

Solubility of 5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl and 5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate

The solubility of the compound 5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl and 5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate can be quite intriguing due to its complex structure and multiple functional groups. Here are some key points regarding its solubility:

  • Polar Functional Groups: The presence of multiple hydroxyl (-OH) and phosphate (-PO4) groups indicates that the compound may possess significant polar characteristics, which typically promote solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds due to these hydroxyl groups can enhance solubility, increasing interactions with solvent molecules.
  • ionic Character: The compound contains an ionizable nitrogen atom within a pyridine moiety. This suggests potential solubility in aqueous solutions, particularly under acidic or basic conditions where protonation or deprotonation can occur.
  • Overall Solubility: Overall, the solubility profile is likely to be favorable in polar environments. However, the actual solubility can vary based on concentration, temperature, and the presence of other solutes.

In summary, while the intricate structure of this compound presents challenges, its polar nature and functional characteristics offer a promising outlook for solubility in aqueous environments. As with many complex molecules, empirical testing is essential to provide definitive solubility data.

Interesting facts

Interesting Facts about the Compound

This compound is a fascinating example of a complex organic molecule that showcases the intricate nature of biochemical interactions. It is part of an important class of compounds known as nucleotide analogs, which are crucial for various biological processes, including DNA and RNA synthesis.

Key Features

  • Biological Relevance: Its structure contains functional groups that can mimic natural nucleotides, making it useful in studying nucleic acid metabolism.
  • Potential Therapeutic Uses: Such compounds are often explored for their potential in antiviral and anticancer therapies due to their ability to interfere with nucleic acid synthesis.
  • Complex Structure: The presence of multiple functional groups, including phosphono and methoxy substituents, enhances its reactivity and interaction with biological macromolecules.

As a scientist or chemistry student, understanding the intricate details of such compounds can greatly enhance our knowledge of molecular biology and pharmaceutical development. Notably, the presence of aminopurine highlights its relation to nucleobases, while its hydroxy and phosphoryl groups play critical roles in biochemical pathways.

Future Directions

Research into this compound may open up new avenues for the development of innovative therapies and diagnostics. Its study could reveal essential insights into enzyme activity and molecular recognition processes, making it a valuable target for future investigations in medicinal chemistry.

In conclusion, compounds like this serve as a reminder of the beauty and complexity of chemistry around us, illustrating how intricate molecular structures can influence life at a cellular level.

Synonyms
1-(5-{[({[5-(6-aminopurin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxy]methyl}-3,4-dihydroxyoxolan-2-yl)-3-carbamoyl-1??-pyridin-1-ylium
SCHEMBL3165614
SCHEMBL20325368
AKOS015894776