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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
[5-[6-amino-8-(6-aminohexylamino)purin-9-yl]-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
State
State

At room temperature, Tenofovir is in a solid state.

Melting point (Celsius)
279.00
Melting point (Kelvin)
552.15
Boiling point (Celsius)
636.00
Boiling point (Kelvin)
909.15
General information
Molecular weight
635.51g/mol
Molar mass
635.5140g/mol
Density
1.4900g/cm3
Appearence

Tenofovir typically appears as a white to off-white powder.

Comment on solubility

Solubility Characteristics

The compound 5-[6-amino-8-(6-aminohexylamino)purin-9-yl]-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate (C9H14N5O4P) exhibits notable solubility behaviors due to its complex structure and the presence of functional groups that influence its interactions with solvents.

Key Points on Solubility

  • Polar Nature: The presence of multiple hydroxyl (-OH) and phosphate (-PO4) groups enhances the compound's ability to dissolve in polar solvents like water.
  • Hydrophobic Interactions: The hydrophobic aliphatic aminohexyl chain may limit solubility in water but can enhance solubility in organic solvents.
  • Temperature Effects: As with many chemical compounds, temperature can significantly impact solubility; higher temperatures typically increase solubility in polar solvents.
  • pH Sensitivity: The solubility may vary with pH changes, particularly due to ionization of the phosphate group, which can alter its solubility characteristics.

Given these factors, it can be stated that while the compound is expected to be soluble in polar solvents, the exact solubility levels will depend on the specific environmental conditions and the presence of other solutes in the solution. It exemplifies the intricate balance between hydrophilic and hydrophobic elements that dictate solubility in the diverse field of chemical compounds.

Interesting facts

Interesting Facts about 5-[6-amino-8-(6-aminohexylamino)purin-9-yl]-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate

This compound represents a fascinating intersection of biochemistry and medicinal chemistry, featuring intricate molecular architecture that suggests potential roles in biological systems. Here are some noteworthy points:

  • Structurally Unique: The molecule incorporates a purine base, which is a fundamental component of nucleic acids like DNA and RNA. This resemblance hints at its potential interactions with biological molecules.
  • Phosphate Group: The presence of the dihydrogen phosphate moiety suggests implications in energy transfer and metabolic pathways, similar to ATP (adenosine triphosphate).
  • Potential Applications: Given its structural components, this compound may have applications in drug design, particularly in targeting enzymatic pathways or as a molecular probe in biochemical research.
  • Amino Chain Functionalities: The aminohexylamino tail provides opportunities for modifications or conjugations that could enhance its bioactivity or specificity toward target proteins.
  • Research Interest: Compounds of this nature are often explored in studies aimed at understanding cellular processes, signaling pathways, and the development of therapeutic agents, especially in cancer and genetic disorders.

In conclusion, 5-[6-amino-8-(6-aminohexylamino)purin-9-yl]-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate is not just a compound with a complex structure; it embodies significant biochemical potential. As research continues to unravel molecular interactions, this compound could serve as a cornerstone for innovations in therapeutic strategies.