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Tenofovir Disoproxil

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Identification
Molecular formula
C9H14N5O4
CAS number
147127-20-6
IUPAC name
[[[5-(6-amino-2-chloro-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl] phosphate
State
State

At room temperature, tenofovir disoproxil is found in a solid state, making it suitable for easy packaging and formulation into oral tablets for medication.

Melting point (Celsius)
118.00
Melting point (Kelvin)
391.15
Boiling point (Celsius)
178.40
Boiling point (Kelvin)
451.55
General information
Molecular weight
263.24g/mol
Molar mass
263.9810g/mol
Density
0.4783g/cm3
Appearence

Typically, tenofovir disoproxil fumarate appears as a white to off-white crystalline powder, highlighting its purity and solid state characteristic. The uniformity in color indicates the precision in its preparation and processing for pharmaceutical applications.

Comment on solubility

Solubility of the Compound

The compound [5-(6-amino-2-chloro-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl phosphate, with the chemical formula C9H14N5O4, presents interesting solubility characteristics due to its complex structure.

Factors Influencing Solubility

The solubility of this compound can be influenced by several factors:

  • Polarity: The presence of hydroxyl (-OH) and phosphate (-PO4) groups typically enhances polarity, suggesting potential solubility in polar solvents.
  • Hydrogen Bonding: The functional groups can participate in hydrogen bonding, which may further promote solubility in aqueous environments.
  • Concentration: As with many organic compounds, increased concentration may lead to the formation of aggregates, which could diminish solubility.

Solubility Behavior

It is essential to consider the following when evaluating the solubility of this compound:

  1. Aqueous Solubility: Given its functional groups, the compound is likely to exhibit moderate to high solubility in water.
  2. Organic Solvents: Solubility may vary in organic solvents, likely showing increased solubility in polar aprotic solvents such as DMSO or DMF.
  3. Temperature Effects: Temperature changes can impact solubility significantly; generally, higher temperatures increase solubility for many compounds.

In summary, the solubility of this compound is likely to be favorable in polar solvents, with its intricate chemical structure playing a crucial role in its solubility characteristics. Understanding these factors is essential for applications in biological systems or chemical formulations.

Interesting facts

Interesting Facts about [5-(6-amino-2-chloro-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl phosphate

This complex compound exemplifies the intricate nature of biochemical substances, especially in the context of nucleic acid research and drug development. Here are some notable aspects:

  • Structural Complexity: The compound contains a combination of a purine moiety and a phosphoryl group. This unique arrangement allows it to play critical roles in biological systems.
  • Pharmaceutical Relevance: Compounds like this one are often explored for their potential as therapeutic agents, particularly in targeting cancer cells by interfering with nucleic acid metabolism.
  • Enzymatic Interactions: The presence of hydroxyl groups enhances its reactivity, potentially allowing it to interact with various enzymes involved in phosphorylation and dephosphorylation processes within the cell.
  • Application in Research: Such compounds are invaluable tools in molecular biology, where they might be utilized to study DNA and RNA synthesis, as well as cellular signaling pathways.
  • Variability in Derivatives: There is a growing interest in modifying the structure of this compound to improve its efficacy and selectivity, making it an exciting focal point for ongoing research.

As we delve deeper into the properties and reactions of compounds like this, we unveil their profound implications in science and medicine. As one researcher aptly put it, "Understanding the molecular intricacies of these compounds can lead to groundbreaking advances in therapeutic strategies."

Overall, this compound represents not only a fascinating study in chemical bonding and structural design but also embodies the promise for future innovations in biochemistry and pharmacology.