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Tenofovir disoproxil fumarate

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Identification
Molecular formula
C19H30N5O10P
CAS number
147127-20-6
IUPAC name
[[5-(6-amino-2-chloro-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate
State
State

At room temperature, Tenofovir disoproxil fumarate is a solid. It is typically provided in a crystalline powder form that is stable under standard conditions of temperature and pressure.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.15
Boiling point (Celsius)
187.90
Boiling point (Kelvin)
461.05
General information
Molecular weight
635.51g/mol
Molar mass
635.5140g/mol
Density
1.6940g/cm3
Appearence

Tenofovir disoproxil fumarate appears as a white to off-white crystalline powder. It is odorless or has a very faint odor. The compound is stable at room temperature and varies in solubility based on the medium, but it is soluble in water.

Comment on solubility

Solubility of [5-(6-amino-2-chloro-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl phosphono hydrogen phosphate

The compound C19H30N5O10P, often found in pharmacological studies, presents interesting characteristics regarding its solubility. Understanding the solubility of this complex compound is critical due to its potential applications in biochemistry and medicinal chemistry.

This compound can be characterized by:

  • Hydrophilicity: The presence of multiple hydroxyl (-OH) groups and a phosphoryl group contributes significantly to its hydrophilic nature, suggesting that it has a propensity to dissolve in aqueous solutions.
  • Influence of Functional Groups: The amino and chlorine substituents may also affect solubility. Generally, amino groups can enhance solubility in polar solvents, while chlorine atoms might have varying effects, depending on their interactions with the solvent molecules.
  • pH Sensitivity: Given that this compound contains acidic and basic functionalities, its solubility might be significantly influenced by pH levels of the medium, which can promote protonation or deprotonation and alter solubility properties.

In summary, the solubility of [5-(6-amino-2-chloro-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl phosphono hydrogen phosphate is expected to be appreciable in polar solvents, particularly water, although the precise solubility could vary with conditions such as temperature and pH. The intricate balance of hydrophobic and hydrophilic features plays a pivotal role in determining its behavior in solution.

Interesting facts

Exploring [5-(6-amino-2-chloro-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate

This compound is quite a fascinating example of biomolecules that bridge organic chemistry with biochemistry. Its complex structure highlights a myriad of functional groups and contributes to its unique properties and potential applications. Here are some intriguing facts:

  • Biological Significance: This compound represents a category of nucleotides that play an essential role in cellular processes, particularly in nucleic acid metabolism.
  • Pharmacological Potential: With elements derived from purine metabolism, it poses interesting possibilities as a pharmaceutical agent. Its structure suggests potential interactions with various biological targets, particularly in the realm of anti-cancer therapies.
  • Chiral Centers: The presence of multiple chiral centers indicates that stereochemistry is crucial for its biological activity. This aspect is vital for chemists in drug design, as even slight alterations in stereo or geometric configuration can lead to significant changes in efficacy and safety.
  • Functional Diversity: The diverse functional groups present, such as amino and hydroxyl groups, give rise to a wide range of reactivity and interaction with biomolecules such as enzymes and receptors.
  • Research Applications: Due to its complex nature, this compound serves as a valuable tool in molecular biology studies, particularly in understanding mechanisms of action of other bioactive compounds.

Overall, the [5-(6-amino-2-chloro-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate is an example of how intricate chemical structures can provide vital clues to biological processes and therapeutic development. As highlighted by the famous saying in chemistry, "If you can’t explain it to a six-year-old, you don’t understand it yourself." This compound serves as an opportunity for both students and scientists to deepen their understanding of chemical intricacies and biological functions.

Synonyms
PD025689