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Cladribine

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Identification
Molecular formula
C10H12ClN5O3
CAS number
4291-63-8
IUPAC name
5-(6-amino-2-chloro-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
State
State

Cladribine is generally in solid form at room temperature.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
750.00
Boiling point (Kelvin)
1 023.15
General information
Molecular weight
285.68g/mol
Molar mass
285.6840g/mol
Density
2.1600g/cm3
Appearence

Cladribine is typically a white to off-white crystalline powder.

Comment on solubility

Solubility of 5-(6-amino-2-chloro-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

The solubility of the compound 5-(6-amino-2-chloro-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol, with the chemical formula C10H12ClN5O3, can be complex and varies with different solvents. Here are some key points to consider:

  • Polarity: Given the presence of hydroxymethyl and amino groups, this compound exhibits polar characteristics, which can enhance its solubility in polar solvents.
  • Solvent Compatibility: Typically, it may dissolve better in water and methanol, while demonstrating limited solubility in organic solvents such as hydrocarbons or non-polar solvents.
  • pH Dependency: The solubility might also be influenced by the pH of the solution. Changes in the protonation states of amino groups can impact solubility significantly.
  • Temperature Effects: Like many chemical compounds, an increase in temperature generally promotes higher solubility, allowing more of the compound to dissolve.

Thus, understanding the solubility behavior of this compound is crucial for applications in pharmaceutical formulations, where solubility significantly affects bioavailability and efficacy.

Interesting facts

Interesting Facts about 5-(6-amino-2-chloro-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

This compound is an intriguing member of the purine derivatives, which are essential in biochemistry given their role in nucleic acids. The structural complexity of this compound highlights the diversity found in chemical functionalities.

Key Features

  • Purine Derivative: As a purine analog, it may be involved in various biochemical processes, acting in pathways related to DNA and RNA synthesis.
  • Pharmacological Potential: Many purine derivatives serve as vital drugs or drug precursors, influencing cellular mechanisms and potentially combating diseases.
  • Functional Groups: The presence of the hydroxymethyl group adds reactivity, potentially enabling further chemical modifications that can enhance biological activity.
  • Chlorine Substitution: The chlorine atom introduces unique properties that might affect both solubility and biological interactions, making it a subject of interest in medicinal chemistry.

Notably, the compound's structure implies it could play a significant role in therapeutic applications. As one student aptly noted, "Exploring the structural nuances of these complex molecules opens a window to innovative drug design." Understanding compounds like this can lead to breakthroughs in treatment strategies, especially in oncology and virology, where purine analogs are extensively studied.

Research Implications

Ongoing studies delve into its synthesis, stability, and interaction with biological systems. Researchers are particularly keen on elucidating how variations in the purine framework affect pharmacodynamics and pharmacokinetics of the resulting compounds.

In summary, 5-(6-amino-2-chloro-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol is more than just a structural marvel; it represents a promising avenue for scientific inquiry in biochemistry, medicinal research, and even advanced materials development. The future of this compound may bring new insights into therapeutic interventions, making it a pivotal subject of study in contemporary chemistry.

Synonyms
5542-92-7
Cladribine Impurity D
CHEMBL17639
5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
NSC105014
SMR000857123
NCGC00018167-03
S1199
2-Chloro-9-(2-deoxy-beta-D-arabinofuranosyl)adenine
cid_1546
NCIOpen2_007300
NCIOpen2_007340
MLS001332517
MLS001332518
SCHEMBL1820786
DTXSID40859857
DTXSID50274315
HMS2230B17
HMS3372K21
HMS3394K13
HMS3654I20
HMS3867N03
BDBM50008366
NSC105013
AKOS015951173
NCGC00018167-04
NCGC00018167-05
IC179959
LS-13779
NCI60_000122
AB00642031-06
2-Chloro-9-(2-deoxypentofuranosyl)-9H-purin-6-amine
5-(6-amino-2-chloro-purin-9-yl)-2-(hydroxy methyl)oxolan-3-ol
5-(6-Amino-2-chloro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-ol