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Adefovir Dipivoxil

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Identification
Molecular formula
C20H32N5O8P
CAS number
106941-25-7
IUPAC name
[5-[(5-amino-2,4-dioxo-1H-pyrimidin-6-yl)amino]-2,3,4-trihydroxy-pentyl] dihydrogen phosphate
State
State

Solid at room temperature.

Melting point (Celsius)
279.00
Melting point (Kelvin)
552.15
Boiling point (Celsius)
890.00
Boiling point (Kelvin)
1 163.15
General information
Molecular weight
501.50g/mol
Molar mass
501.5030g/mol
Density
2.4955g/cm3
Appearence

White powder or crystalline solid.

Comment on solubility

Solubility of 5-[(5-amino-2,4-dioxo-1H-pyrimidin-6-yl)amino]-2,3,4-trihydroxy-pentyl dihydrogen phosphate

The solubility of the compound C20H32N5O8P is influenced by several key factors due to its unique structural properties. This compound, which contains both hydrophilic and hydrophobic regions, presents a somewhat complex solubility behavior.

Key Factors Affecting Solubility:

  • Hydrophilicity: The presence of multiple hydroxyl groups (-OH) and a phosphate group (-PO4) greatly enhances its aqueous solubility.
  • Hydrophobic Characteristics: The aromatic and aliphatic sections of the molecule may impart limited solubility in non-polar solvents.
  • pH Dependency: The solubility can vary with pH, especially due to the ionizable nature of the phosphate group; it is generally more soluble in basic solutions compared to acidic ones.
  • Temperature Effects: As with many chemical compounds, increased temperature can lead to enhanced solubility.

In summary, while 5-[(5-amino-2,4-dioxo-1H-pyrimidin-6-yl)amino]-2,3,4-trihydroxy-pentyl dihydrogen phosphate is likely to exhibit good solubility in polar solvents such as water, its solubility may diminish in non-polar environments. Consequently, understanding the solubility profile of this compound is essential for its practical application in various chemical and biological contexts.

Interesting facts

Interesting Facts about 5-[(5-Amino-2,4-dioxo-1H-pyrimidin-6-yl)amino]-2,3,4-trihydroxy-pentyl Dihydrogen Phosphate

This intriguing compound features a multifunctional structure that highlights the versatility of organic molecules in biological systems. Here are some captivating aspects of this compound:

  • Biological Importance: This compound plays a crucial role in cellular metabolism, as it may act as a phosphate donor in enzymatic reactions.
  • Pyrimidine Derivative: The presence of a pyrimidine ring in its structure makes it relevant in the synthesis of nucleic acids, which are essential for genetic information storage and transfer.
  • Potential Therapeutic Applications: The unique combination of trihydroxy pentyl and amino groups suggests potential applications in medicinal chemistry, particularly as a scaffold for drug development targeting metabolic pathways.
  • Hydrophilicity: The trihydroxy groups contribute to the compound's hydrophilic nature, which can enhance solubility in biological media, facilitating its interaction with various biomolecules.
  • Structural Complexity: Its intricate molecular design allows for multiple points of chemical interaction, making it interesting for studies involving enzyme-substrate relationships.

In the realm of chemistry, the convergence of functionalities in this compound embodies the principle of structure-activity relationship (SAR). As scientists delve into its properties and behaviors, they open doors to new findings related to biochemical pathways and therapeutic developments. This compound is a stunning example of how chemistry intersects with biology, highlighting the potential for groundbreaking research and discovery.

Synonyms
RQRINYISXYAZKL-UHFFFAOYSA-N
5-amino-6 (5'phosphoribitylamino)uracil
5-amino-6-(5'phosphoribitylamino)uracil