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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
[[5-(4-amino-2-oxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate
State
State

At room temperature, tenofovir is typically encountered as a solid. It is often prepared as a salt for pharmaceutical formulations to enhance solubility and absorption.

Melting point (Celsius)
276.00
Melting point (Kelvin)
549.20
Boiling point (Celsius)
425.70
Boiling point (Kelvin)
698.90
General information
Molecular weight
305.23g/mol
Molar mass
305.2340g/mol
Density
2.3560g/cm3
Appearence

Tenofovir disoproxil fumarate appears as a white to off-white crystalline powder. It is soluble in methanol and water, which is helpful in the formulation of the drug into tablet form for administration.

Comment on solubility

Solubility of [5-(4-amino-2-oxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl phosphono hydrogen phosphate

The solubility of the compound C9H14N5O4P, commonly known for its complex structure, can be influenced by various factors such as pH, temperature, and the presence of other solutes. Here are some key points to consider:

  • Polarity: The presence of multiple functional groups, including amino, methoxy, and phosphoryl, plays a crucial role in its overall polarity, which significantly affects solubility.
  • Solvent Compatibility: This compound is likely to be more soluble in polar solvents such as water or dimethyl sulfoxide (DMSO), owing to its hydrophilic nature attributable to the phosphate and amino groups.
  • pH Dependence: The solubility may increase in alkaline conditions where protonation states of the functional groups can be altered, enhancing interactions with solvent molecules.
  • Temperature Effects: Like many chemical compounds, an increase in temperature can potentially enhance solubility, promoting interactions between solvent and solute molecules.

In conclusion, while specific quantitative solubility data for this compound may not be readily available, understanding its structural features and functional groups provides valuable insight into its likely solubility behavior. Overall, one can infer that this compound may exhibit considerable solubility in appropriate polar solvents, contingent upon environmental conditions such as pH and temperature.

Interesting facts

Interesting Facts about [5-(4-amino-2-oxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate

This unique compound, often discussed within the realm of biochemistry, showcases a fascinating interplay between organic and inorganic chemistry. Here are some engaging facts about this intricate molecule:

  • Role in Biochemical Pathways: Compounds of this nature are often involved in crucial biochemical processes, particularly in the fields of nucleic acid metabolism and signal transduction. They may serve as intermediates or precursors in the biosynthesis of nucleotides.
  • Phosphorylation Potential: The presence of phosphoryl and phosphono groups hints at its role in phosphorylation reactions. Phosphorylation is a key regulatory mechanism in cells, influencing protein function and cellular signaling.
  • Therapeutic Applications: Due to its structural intricacies, this compound could play a role in drug design, particularly in creating novel therapeutic agents targeting specific receptors or enzymes in pathogenic organisms.
  • Chemical Diversity: The combination of a tetrahydrofuran moiety and a pyrimidinyl group indicates a rich chemical diversity which can lead to multiple derivatives, allowing chemists to explore a wide range of functional properties and potential applications.
  • Synthesis Challenges: The synthesis of such complex molecules often presents unique challenges, prompting innovative approaches in organic synthesis techniques. Understanding these challenges can enhance students' and researchers’ problem-solving skills.

As with many pharmaceuticals and biologically active compounds, the journey from synthesis to application is laden with intriguing scientific inquiry and discovery. Whether exploring their mechanisms of action or investigating new synthetic pathways, compounds like this fuel the ongoing quest for knowledge in the chemical sciences.

Synonyms
SCHEMBL20879464
2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE LITHIUM SALT