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Uridine diphosphate

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Identification
Molecular formula
C9H14N2O12P2
CAS number
58-98-0
IUPAC name
[5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate
State
State
At room temperature, uridine diphosphate is typically found in a solid state as a crystalline powder.
Melting point (Celsius)
200.00
Melting point (Kelvin)
473.15
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.15
General information
Molecular weight
404.20g/mol
Molar mass
404.2010g/mol
Density
1.6000g/cm3
Appearence
Uridine diphosphate typically appears as a white to off-white crystalline powder, characteristic of many nucleotides. Its solid state is crystalline due to the regular, repeating structure of the molecules in its composition.
Comment on solubility

Solubility of [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

The solubility of the compound with the formula C9H14N2O12P2 is influenced by various structural and functional characteristics. Here are some key points regarding its solubility:

  • Polarity: Due to the presence of multiple hydroxyl (-OH) and phosphate groups, the compound is expected to exhibit high polarity, enhancing its solubility in polar solvents such as water.
  • Hydrogen Bonding: The functional groups can form hydrogen bonds with water, which typically facilitates solubility. Molecules with the ability to engage in such bonding are often more soluble.
  • pH Dependence: The ionization of the phosphate groups can vary in different pH conditions, affecting solubility. For example, increased acidity could enhance solubility due to increased ionization.
  • Structural Considerations: The presence of the pyrimidine ring and its substitutions may introduce steric effects influencing solubility. Complex molecules might demonstrate variable solubility patterns based on the specific arrangement of their components.

In summary, the solubility of [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate is likely substantial in polar solvents, but may still exhibit variability based on specific environmental conditions such as pH and the solvent's nature. Further experimentation is required to quantify the solubility accurately.

Interesting facts

Interesting Facts about [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

This compound is a remarkable example of a hybrid molecule that bridges the fields of medicinal chemistry and molecular biology. With its unique structural features and functional groups, it offers a multitude of potential applications and interesting characteristics:

  • Phosphono Group: The presence of a phosphono group enhances the compound's reactivity and biological activity, making it a potential candidate for antiviral or anticancer therapies.
  • Amino-Pyrimidine Structure: The 4-amino-2-oxo-pyrimidine moiety is known for its role in nucleotide metabolism and can influence genomic stability and gene expression.
  • Tetrahydrofuran Ring: The dihydroxy-tetrahydrofuran unit contributes to the solubility and interaction with biological targets, hinting at its efficacy in drug design.

In the study of nucleotides and nucleosides, compounds like this one are significant for their capability to mimic natural substrates. Researchers say, "Understanding intricate structures of potential therapeutic agents is crucial for advancing drug development." The multi-faceted nature of this compound allows for investigations not only into its structural characteristics but also its potential therapeutic effects.

Additionally, it's worth noting that such hybrid compounds can be pivotal in the development of enzyme inhibitors, offering insight into how specific biological pathways can be manipulated for therapeutic gain. As we delve deeper into its synthesis and properties, the implications for pharmaceutical chemistry are vast, raising intriguing questions about its role in targeting diseases at the molecular level.

Synonyms
4-amino-1-{5-o-[hydroxy(phosphonooxy)phosphoryl]pentofuranosyl}pyrimidin-2(1h)-one
[5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate
(5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate
4-Amino-1-(5-o-(hydroxy(phosphonooxy)phosphoryl)pentofuranosyl)pyrimidin-2(1h)-one
(5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methyl phosphono hydrogen phosphate
SCHEMBL18785150
DTXSID30861606
NS00041341
[(2S,3R,4R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate