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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
[[5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] 2,3-dihydroxypropyl hydrogen phosphate
State
State

Tenofovir is typically found in a solid state at room temperature. It is stable under normal conditions and is usually compounded in pharmaceutical forms such as tablets or powders for medicinal use.

Melting point (Celsius)
117.00
Melting point (Kelvin)
390.15
Boiling point (Celsius)
204.00
Boiling point (Kelvin)
477.15
General information
Molecular weight
287.21g/mol
Molar mass
304.2290g/mol
Density
1.4900g/cm3
Appearence

Tenofovir generally appears as a white to off-white crystalline powder. When in pure form, it is typically odorless and has a slightly bitter taste.

Comment on solubility

Solubility Characteristics

The compound [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl 2,3-dihydroxypropyl hydrogen phosphate (C9H14N5O4P) exhibits specific solubility characteristics that are noteworthy in various solvents.


Solubility in Water

  • High Polarity: Due to the presence of multiple hydroxyl groups and phosphate moiety, this compound tends to be highly soluble in water.
  • Hydrogen Bonding: The capacity to form hydrogen bonds with water molecules enhances its solubility in aqueous solutions.

Solubility in Organic Solvents

  • Limited Solubility: In organic solvents, the solubility may be limited due to the polar nature of the compound.
  • Effect of Solvent Properties: The interaction with non-polar solvents is generally weak, which could lead to precipitation or low solubility.

Therefore, it can be concluded that water is the most suitable solvent for this compound, while organic solvents may not be ideal for achieving high solubility levels.

Interesting facts

Interesting Facts about [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl 2,3-dihydroxypropyl hydrogen phosphate

This compound represents a fascinating intersection of organic chemistry and biotechnology, elucidating the ways in which chemical structures can contribute to biological functions.

Unique Structural Features

The compound is characterized by multiple functional groups and heterocycles, which contribute to its potential biological activity. Key features include:

  • Pyrimidine ring: This structure is known for its role in nucleobases, which are essential for the formation of DNA and RNA.
  • Phosphate group: Often involved in energy transfer and signaling within cells, phosphate groups are critical in many biochemical processes.
  • Hydroxyl groups: These contribute to the compound's hydrophilicity, enhancing solubility and reactivity with other molecules.

Biological Relevance

This compound could be of particular interest due to its potential applications in:

  • Pharmaceuticals: Structures similar to this are often investigated for their abilities to serve as drug candidates.
  • Biochemical pathways: The compound might play a role in metabolic processes, particularly those related to nucleic acid metabolism.

Quote from the Field

As noted by researchers in pharmacology, "The interplay of various functional groups within a compound can unveil new pathways for therapeutic intervention." This emphasizes the importance of exploring such intricate structures.

In conclusion, [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl 2,3-dihydroxypropyl hydrogen phosphate is more than just a chemical entity; it represents a rich platform for scientific exploration and advancements in both chemistry and medicine.