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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
[[5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate
State
State

At room temperature, Tenofovir is a solid compound, typically utilized in tablet or powder form for medical formulations. In its pure state, it presents as a crystalline powder.

Melting point (Celsius)
279.00
Melting point (Kelvin)
552.00
Boiling point (Celsius)
370.00
Boiling point (Kelvin)
643.00
General information
Molecular weight
287.22g/mol
Molar mass
287.2150g/mol
Density
1.4970g/cm3
Appearence

Tenofovir appears as a white to off-white crystalline powder. It is commonly used in its disoproxil or alafenamide form as an antiviral medication.

Comment on solubility

Solubility of [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl phosphono hydrogen phosphate

The solubility of complex compounds like [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl phosphono hydrogen phosphate (C9H14N5O4P) can often present intriguing challenges due to their multifaceted chemical structures.

This particular compound is characterized by a unique combination of functional groups that may influence its solubility in various solvents. In general:

  • Water solubility: The presence of multiple hydroxyl (-OH) groups suggests potential for good solubility in water due to hydrogen bonding.
  • Solvent interaction: As a phosphorylated compound, its solubility may also vary with pH, indicating that it could be soluble in either acidic or basic conditions if the right ionic equilibria are achieved.
  • Non-polar solvents: Given its polar parts and complex structure, solubility in non-polar solvents is likely to be limited.

In summary, while there is potential for substantial solubility in aqueous solutions due to polar functional groups, the overall solubility will depend largely on the specific conditions of the solution, such as temperature and pH. It is essential to approach the evaluation of solubility for such compounds on a case-by-case basis, taking into account the overall molecular architecture and environmental factors.

Interesting facts

Interesting Facts about [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl phosphono hydrogen phosphate

The compound described is a fascinating example of a complex organic phosphonate, which plays an essential role in biochemistry and pharmaceutical research. Here are some intriguing aspects:

  • Bioactivity: This compound is part of a group of molecules that exhibit significant biological activity, often interacting with enzymes, nucleic acids, or other vital cellular components.
  • Phosphorylation: The presence of the phosphoryl group indicates its involvement in phosphorylation processes, which are crucial for signal transduction and energy metabolism in living organisms.
  • Structural Diversity: The intricate structure, featuring a pyrimidine ring and tetrahydrofuran moiety, highlights the chemical diversity available in organic compounds and their potential for unique biological functions.
  • Potential as a Drug Candidate: Given its structural attributes, this compound may have applications as a lead in drug discovery, particularly in developing treatments for conditions related to cellular signaling and metabolism.

As a chemistry student examining this compound, one might consider the implications of its structure-function relationship in biological systems. It emphasizes the importance of molecular architecture in creating compounds with precise and impactful biological roles. Moreover, as the field of medicinal chemistry advances, compounds such as this represent a blend of design and nature's ingenuity, potentially yielding new pharmacological agents.

In summary, the combination of unique chemical properties, structural complexity, and potential applications encapsulates the excitement surrounding this phosphonate, motivating further study and exploration in the field of chemistry.

Synonyms
Cytidine triphosphate disodium salt
SCHEMBL15958751
DTXSID20861610
NSC20261
[[5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
NS00041321
L001091
4-Amino-1-[5-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)pentofuranosyl]pyrimidin-2(1H)-one