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Tenofovir disoproxil

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Identification
Molecular formula
C19H30N5O10P
CAS number
147127-20-6
IUPAC name
[[5-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate
State
State

At room temperature, Tenofovir disoproxil is in the form of a solid crystalline powder.

Melting point (Celsius)
117.00
Melting point (Kelvin)
390.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
518.49g/mol
Molar mass
518.4920g/mol
Density
1.2580g/cm3
Appearence

Tenofovir disoproxil is a white to off-white crystalline powder with a slight odor. It is soluble in water and has a characteristic appearance of small, solid crystals when observed under a microscope.

Comment on solubility

Solubility Overview

The compound [5-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate, with the chemical formula C19H30N5O10P, exhibits unique solubility characteristics that can greatly influence its applications in various fields.

Factors Affecting Solubility

Several factors contribute to the solubility of this compound:

  • Polarity: The presence of multiple functional groups such as amino and hydroxyl groups enhances its polarity, which often leads to increased solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds due to hydroxyl and amino groups further supports solubility in aqueous environments.
  • Thermodynamics: The enthalpic and entropic factors when dissolving in solvents can play a significant role in whether the compound is highly soluble or not.

Solubility in Different Solvents

Typically, one might observe the following solubility behavior:

  • Highly soluble in polar solvents such as water due to hydrogen bonding and polarity.
  • Low solubility in non-polar solvents, as the lack of polar interactions limits dissolution.

Conclusion

In essence, while the solubility of this compound suggests it can be effectively used in aqueous applications, it is critical to consider the specific solvent interactions. As with many chemical compounds, understanding its solubility profile is essential for optimizing its use in research and practical applications.

Interesting facts

Interesting Facts about [5-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate

This compound is quite intriguing for its multifaceted structure and potential applications in various fields, especially in biochemistry and pharmaceuticals. Here are some captivating aspects:

  • Structural Diversity: The compound features a unique combination of a pyrimidine base and a tetrahydrofuran moiety, which contributes to its diverse chemical properties.
  • Biological Relevance: Compounds like this one can serve as important intermediates in the synthesis of nucleoside analogs, which are vital in antiviral and anticancer therapies.
  • Phosphorylation: The presence of a phosphoryl group enhances the biological activity of many molecules. This compound may exhibit similar characteristics, making it a subject of study in enzyme interactions.
  • Synthetic Pathways: The complexity of its synthesis offers insights into multi-step synthesis strategies used to create intricate compounds with numerous functional groups.
  • Research Opportunities: Given its unique components, there is a potential for studying the compound's interactions with biological systems, paving the way for new pharmaceuticals.

As a chemistry student, you might find it fascinating to explore how small changes in the molecular structure can significantly alter the compound's reactivity and biological properties. Understanding such relationships is essential for designing new molecules tailored for specific applications.

In the words of a renowned chemist, "Chemistry is the art of transformation." This compound exemplifies how intricate molecular architectures can lead to profound chemical behavior and utility.

Synonyms
[[5-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
4-Amino-1-[2-deoxy-5-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)pentofuranosyl]pyrimidin-2(1H)-one
((5-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl)methoxy-hydroxyphosphoryl) phosphono hydrogen phosphate
4-Amino-1-(2-deoxy-5-O-(hydroxy((hydroxy(phosphonooxy)phosphoryl)oxy)phosphoryl)pentofuranosyl)pyrimidin-2(1H)-one
SCHEMBL12729518
DTXSID00862822
PD041655