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Nicotine lactam

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Identification
Molecular formula
C9H10N2O
CAS number
38741-23-8
IUPAC name
5-(3-pyridyl)pyrrolidin-2-one
State
State

Nicotine lactam is typically found as a crystalline solid at room temperature.

Melting point (Celsius)
79.00
Melting point (Kelvin)
352.15
Boiling point (Celsius)
312.20
Boiling point (Kelvin)
585.35
General information
Molecular weight
162.20g/mol
Molar mass
162.2010g/mol
Density
1.1678g/cm3
Appearence

Nicotine lactam is typically a crystalline solid. It may appear as a white or off-white powdered substance when isolated and purified.

Comment on solubility

Solubility of 5-(3-pyridyl)pyrrolidin-2-one

The solubility of 5-(3-pyridyl)pyrrolidin-2-one (C9H10N2O) is an interesting aspect to consider due to its potential applications in various fields. Here are some key points regarding its solubility:

  • The compound is expected to be polar due to the presence of both a carbonyl group and a nitrogen atom in its structure.
  • As a result of this polarity, 5-(3-pyridyl)pyrrolidin-2-one is likely to exhibit a moderate solubility in water.
  • It may also be soluble in various organic solvents, which can enhance its versatility in chemical applications.

However, the solubility of this compound can also be influenced by several factors, including:

  • Temperature: Higher temperatures generally increase solubility.
  • pH of the solution: The presence of acidic or basic conditions may alter the ionic state of the compound.
  • Presence of other solutes: Co-solvents or other solutes can impact the overall solubility balance.

In conclusion, while 5-(3-pyridyl)pyrrolidin-2-one is expected to demonstrate notable solubility characteristics, specific empirical data would provide a more precise understanding of its behavior in different environments.

Interesting facts

Interesting Facts about 5-(3-pyridyl)pyrrolidin-2-one

5-(3-pyridyl)pyrrolidin-2-one is a fascinating compound that has garnered interest in various fields of scientific research. Here are some intriguing aspects of this compound:

  • Biological Applications: This compound serves as a crucial intermediate in the synthesis of several biologically active molecules. Its structural features make it a target in medicinal chemistry for developing novel pharmaceuticals.
  • Pyridine Connection: The presence of a pyridine ring attached to the pyrrolidinone skeleton enhances its potential as a ligand in coordination chemistry, facilitating interaction with metal ions.
  • Neurochemical Interest: Due to its structural motif, the compound is also being explored for its potential effects on neurological pathways, potentially influencing conditions such as anxiety and depression.
  • Synthetic Versatility: The synthesis of 5-(3-pyridyl)pyrrolidin-2-one often involves multi-step reactions that can yield diverse derivatives, making it a significant subject of study in organic chemistry.
  • Research Opportunities: It opens the door to exploring structure-activity relationships as researchers investigate how variations in its molecular structure can affect biological properties.

In the words of a chemistry student: "Compounds like 5-(3-pyridyl)pyrrolidin-2-one remind us of the beauty of chemistry, where slight changes in composition can lead to vast differences in function and application."

This compound is definitely one to watch in the realms of both chemical synthesis and pharmacology, providing endless opportunities for innovation and discovery in future research.

Synonyms
norcotinine
(R,S)-Norcotinine
17708-87-1
5-(PYRIDIN-3-YL)PYRROLIDIN-2-ONE
5-pyridin-3-ylpyrrolidin-2-one
17114-40-8
5-(3-pyridinyl)-2-pyrrolidinone
(RS)-Norcotinine
5-Pyridin-3-yl-pyrrolidin-2-one
(S)-5-Pyridin-3-yl-pyrrolidin-2-one
CHEBI:89406
DTXSID10864736
(R)-5-Pyridin-3-yl-pyrrolidin-2-one
(5RS)-5-(Pyridin-3-yl)pyrrolidin-2-one ((RS)-Norcotinine)
(+-)-Norcotinine
(R,S)-Norcotinine ( 1.0 mg/mL in Methanol)
rac-Norcotinine
Desmethylcotinine
(RS)-Norcotinine; 2-Pyrrolidinone, 5-(3-pyridinyl)-, (+/-)-; Norcotinine, (+/-)- (8CI); (+/-)-Demethylcotinine; (+/-)-Norcotinine
(A+/-)-Norcotinine
5-(3-pyridyl)-2-pyrrolidone
SCHEMBL2788897
CHEMBL3126030
DTXCID60813219
FXFANIORDKRCCA-UHFFFAOYSA-N
FAA98006
2-Pyrrolidinone, 5-(3-pyridinyl)-
AKOS006278969
CS-W010859
FN26434
SB31675
SB34310
SB37864
rac-Norcotinine 1.0 mg/ml in Methanol
NS00115021
Q27161596
5-(3-Pyridinyl)-2-pyrrolidinone;(+/-)-Demethylcotinine
682-536-0
803-191-6