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5-(3-Methylpiperazin-1-yl)sulfonylisoquinoline

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Identification
Molecular formula
C14H17N3O2S
CAS number
39718-87-7
IUPAC name
5-(3-methylpiperazin-1-yl)sulfonylisoquinoline
State
State
At room temperature, 5-(3-Methylpiperazin-1-yl)sulfonylisoquinoline is generally found as a solid. This compound is stable under ambient conditions, provided it is stored properly to prevent moisture ingress or decomposition.
Melting point (Celsius)
212.00
Melting point (Kelvin)
485.20
Boiling point (Celsius)
520.10
Boiling point (Kelvin)
793.20
General information
Molecular weight
291.37g/mol
Molar mass
291.3700g/mol
Density
1.3100g/cm3
Appearence

5-(3-Methylpiperazin-1-yl)sulfonylisoquinoline typically appears as a crystalline solid. The exact color and form can vary slightly depending on purity and conditions of the synthesis but it is usually white to off-white. It is used in various chemical syntheses and requires careful handling due to its potential reactivity.

Comment on solubility

Solubility of 5-(3-methylpiperazin-1-yl)sulfonylisoquinoline

The solubility of 5-(3-methylpiperazin-1-yl)sulfonylisoquinoline, with the chemical formula C14H17N3O2S, exhibits some intriguing characteristics that depend on various factors:

  • Polarity: The presence of the sulfonyl group and the nitrogen-containing piperazine ring suggests that the compound may have a polar character, which can influence its solubility in polar solvents.
  • Solvents: Generally, compounds with similar polarities tend to be soluble in each other. Therefore, 5-(3-methylpiperazin-1-yl)sulfonylisoquinoline might show good solubility in:
    • Water
    • Alcohols
    • Aqueous solutions
  • Temperature Dependence: As with many organic compounds, solubility can change with temperature. An increase in temperature often enhances solubility, particularly in solid compounds.
  • Structural Influence: The isoquinoline structure, along with the piperazine substitution, often contributes to altered solubility patterns, potentially making the compound enter the realm of moderate solubility.

In summary, while the precise solubility profile of 5-(3-methylpiperazin-1-yl)sulfonylisoquinoline will depend on experimental conditions, its polar characteristics suggest it may be soluble in polar solvents. As stated, "the solvent is the key that unlocks the solubility door." Understanding these nuances is crucial for practical applications in pharmaceuticals and related fields.

Interesting facts

Interesting Facts about 5-(3-methylpiperazin-1-yl)sulfonylisoquinoline

The compound 5-(3-methylpiperazin-1-yl)sulfonylisoquinoline is a fascinating example of how medicinal chemistry intertwines complex aromatic compounds with piperazine derivatives to achieve desired biological activity. Here are several intriguing aspects of this compound:

  • Pharmacological Potential: Due to its unique structure, this compound has attracted interest in pharmaceutical research for its potential role as a drug candidate. Its isoquinoline backbone, associated with various biological activities, opens avenues for drug development aimed at conditions like psychiatric disorders or certain cancers.
  • Sulfonamide Appeal: The sulfonyl group incorporated in this compound is known for its versatility in enhancing solubility and bioactivity. Sulfonamides are often recognized for their antimicrobial properties, making their derivatives valuable in medicinal applications.
  • Piperazine Influence: The presence of the 3-methylpiperazin-1-yl moiety contributes to the compound's interactions with biological targets. Piperazine rings are well-documented in numerous drugs, providing significant influence in altering pharmacokinetics and pharmacodynamics.
  • Structure-Activity Relationship (SAR): Investigating this compound helps chemists understand the structure-activity relationships, which is essential for designing more effective drugs. Minor alterations in chemical structure can lead to substantial changes in biological activity.
  • Research Opportunities: Emerging studies focus on this compound to explore its effects on neurotransmitter systems, which could potentially lead to innovative therapeutic strategies for mental health conditions.

In summary, 5-(3-methylpiperazin-1-yl)sulfonylisoquinoline serves as a rich subject for research and exploration in medicinal chemistry, showcasing the intricate relationship between chemical structure and biological function.

Synonyms
84477-73-6
1-(5-Isoquinolinylsulfonyl)-3-methylpiperazine
Iso-H-7
1-(5-isoquinolinesulfonyl)-3-methylpiperazine
ISO-H7
5-(3-methylpiperazin-1-yl)sulfonylisoquinoline
5-((3-Methylpiperazin-1-yl)sulfonyl)isoquinoline
NSC683547
1-(5-ISOQUINOLINYLSULFONYL)-3-METHYL-PIPERAZINE
Lopac0_000662
Oprea1_059623
Piperazine, 1-(5-isoquinolinylsulfonyl)-3-methyl-
SCHEMBL1165362
CHEMBL1555085
BDBM86727
DTXSID701004755
AKOS009158819
CCG-204748
NSC-683547
SDCCGSBI-0050641.P002
NCGC00015561-02
NCGC00015561-03
NCGC00162215-01
CAS_140663-38-3
1-(6-Isoquinolylsulfonyl)-3-methylpiperazine
5-(3-Methylpiperazine-1-sulfonyl)isoquinoline
1-(5-isoquinolinesulfonyl)-2-methylpiperazine.2hcl
Z1262449272
1-(5-Isoquinolinesulfonyl)-3-methylpiperazine, >=98.0% (HPLC)