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Thymidine monophosphate

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Identification
Molecular formula
C10H14N2O8P
CAS number
365-07-1
IUPAC name
[5-[(2,5-diamino-4-oxo-1H-pyrimidin-6-yl)amino]-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
State
State

Thymidine monophosphate is typically in a solid state at room temperature. It is stable under standard conditions and readily soluble in water, which is characteristic of many phosphate compounds.

Melting point (Celsius)
181.00
Melting point (Kelvin)
454.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
322.20g/mol
Molar mass
176.0130g/mol
Density
2.1300g/cm3
Appearence

Thymidine monophosphate typically appears as a white crystalline powder. It is hygroscopic, meaning it can absorb moisture from the environment, which may affect its appearance if not stored properly.

Comment on solubility

Solubility of the Compound

The compound [5-[(2,5-diamino-4-oxo-1H-pyrimidin-6-yl)amino]-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate (C10H14N2O8P) exhibits notable solubility characteristics due to its ionic and polar nature. Here are some key points related to its solubility:

  • Highly Soluble in Water: The presence of multiple hydroxyl groups and the dihydrogen phosphate moiety contribute to its high solubility in aqueous solutions. This is typical for compounds containing polar functional groups.
  • Influence of pH: The solubility might change with varying pH levels, as the ionization state of the phosphate group can alter. Thus, it may have increased solubility in acidic environments.
  • Organic Solvents: The compound's solubility in organic solvents may be limited due to the polar and ionic nature of its functional groups. However, it may show some solubility in polar organic solvents.
  • Temperature Dependence: Like many substances, its solubility is likely to increase with temperature, allowing more of the compound to dissolve in solution.

In conclusion, the solubility of this compound is a fascinating interplay of its molecular structure and environmental conditions, making it an intriguing subject for further study in both pharmaceutical and biochemical applications.

Interesting facts

Interesting Facts about 5-[(2,5-diamino-4-oxo-1H-pyrimidin-6-yl)amino]-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate

This complex compound showcases a unique blend of structural elements that are intriguing for both chemical and biological applications. Here's what makes it particularly interesting:

  • Pharmaceutical Relevance: This compound represents a novel structure that may play a role in pharmaceutical development, particularly in the realm of nucleic acid metabolism and cancer treatment. Small molecules that mimic nucleobases can be pivotal in disrupting the growth of malignant cells.
  • Functional Groups: The presence of multiple functional groups such as pyrimidines, amines, and phosphates enhances its potential for forming hydrogen bonds, which can contribute to its biological activity and stability. These interactions are critical in designing inhibitors or modulators in various biochemical pathways.
  • Versatile Tetrahydrofuran Structure: The tetrahydrofuran moiety in this compound suggests increased solubility and flexibility, which could improve the bioavailability of potential drug formulations. This can be essential in the synthesis of prodrugs that require metabolic activation.
  • Potential for Molecular Targeting: Given the dual role of the compound as a carrier and an active agent, it's a candidate for targeted delivery systems. By attaching bioactive molecules, it could be used in delivering therapies directly to specific tissues, reducing side effects.
  • Research Opportunities: As a chemical scientist or student, this compound opens doors to explore synthetic pathways for its creation and the effects of varying substituents on its properties and activities, making it an excellent focus for research projects.

In summary, the 5-[(2,5-diamino-4-oxo-1H-pyrimidin-6-yl)amino]-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate is a fascinating compound that embodies the intersection of organic chemistry and biochemistry, offering numerous avenues for exploration and application in science.