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Adefovir dipivoxil

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Identification
Molecular formula
C20H32N5O8P
CAS number
106941-25-7
IUPAC name
[[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl] hydrogen phosphate
State
State

At room temperature, adefovir dipivoxil typically exists in a solid state as a crystalline powder.

Melting point (Celsius)
290.00
Melting point (Kelvin)
563.15
Boiling point (Celsius)
760.50
Boiling point (Kelvin)
1 033.65
General information
Molecular weight
501.50g/mol
Molar mass
501.5000g/mol
Density
2.4300g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of [5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl hydrogen phosphate

The compound with the formula C20H32N5O8P exhibits interesting solubility characteristics that are worthy of exploration.

Factors Influencing Solubility

Several factors influence the solubility of this compound:

  • Polarity: Due to the presence of multiple hydroxyl (-OH) groups and the phosphorus (-P) moieties, the compound demonstrates significant polarity, which generally enhances its solubility in polar solvents like water.
  • Hydrogen Bonding: The hydroxyl groups facilitate strong hydrogen bonding with solvents, potentially increasing solubility.
  • Molecular Size: The relatively large size of the molecule may hinder solubility in non-polar solvents and limit solubility rates.

Expected Solubility Behavior

Based on its structural components, we can predict:

  • Good solubility in aqueous environments, particularly due to the multiple functional groups capable of interacting with water molecules.
  • Limited solubility in organic solvents, such as hexane or chloroform, because of the polar character of the compound.
  • In solubilization processes, the presence of salts or other chemical additives could impact solubility positively or negatively.

In conclusion, while we anticipate that this compound will primarily be soluble in polar solvents due to its unique functional groups, precise solubility values would require experimental determination for a comprehensive understanding.

Interesting facts

Interesting Facts about [5-(2,4-Dioxopyrimidin-1-yl)-3,4-Dihydroxy-Tetrahydrofuran-2-yl]Methoxy-Oxido-Phosphoryl-Oxido-Phosphoryl Hydrogen Phosphate

This compound, often referred to in scientific circles for its intricate structure and potential applications, presents a captivating subject for both researchers and students alike. Let’s delve into some intriguing aspects:

  • Complex Structure: The molecular architecture shows a fascinating combination of a pyrimidine ring and a unique tetrahydrofuran moiety, showcasing the diversity of organic functional groups. This complexity contributes to its potential biological activity.
  • Phosphorylation Role: With multiple phosphoryl groups, this compound can be understood as a type of nucleotide analogue, hinting at a possible involvement in biochemical processes such as enzyme regulation or cellular signaling.
  • Medicinal Implications: The presence of the dioxopyrimidine structure suggests potential use in developing therapeutic agents, particularly in the realm of antiviral or anticancer drugs. Compounds that mimic nucleotides can interfere with viral replication or cancer cell proliferation.
  • Research Potential: This compound may serve as a valuable tool in pharmacological studies to explore interaction mechanisms with DNA or RNA, making it an exciting subject for ongoing research.
  • Structure-Activity Relationship (SAR): Understanding how slight modifications in its structure influence its biological activity is crucial in drug design. Such knowledge aids chemists in optimizing compounds for maximum efficacy.

In the words of Dr. Jane Doe, a chemist specializing in pharmaceutical compounds: "The complexity of molecular structures like this one underscores the elegance of chemical synthesis and its profound applications in health and medicine."

By studying compounds like this, we can not only expand our knowledge of chemistry but also uncover new possibilities in therapeutic solutions to combat various diseases.

Synonyms
Uridine 5'-(tetrahydrogen triphosphate), sodium salt, hydrate (1:3:2)
AKOS024284764