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Tetrahydrouridine monophosphate

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Identification
Molecular formula
C9H15N2O9P
CAS number
66134-78-7
IUPAC name
[5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate
State
State

At room temperature, the compound is typically a solid.

Melting point (Celsius)
229.00
Melting point (Kelvin)
502.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
354.20g/mol
Molar mass
354.1310g/mol
Density
2.3000g/cm3
Appearence

The compound is a white crystalline powder.

Comment on solubility

Solubility of [5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

The solubility of the compound C9H15N2O9P can be influenced by several factors, including its molecular structure and interactions with solvents. Generally speaking, *phosphono hydrogen phosphates* exhibit intriguing solubility characteristics:

  • Polar Solvents: This compound is likely to be soluble in water and other polar solvents due to the presence of multiple functional groups capable of hydrogen bonding, such as the hydroxyl and phosphate groups.
  • Non-polar Solvents: Solubility in non-polar solvents is expected to be low, given the polar nature of its constituent groups and the absence of long hydrophobic chains that typically enhance non-polar solubility.
  • pH Dependency: The solubility might also vary with pH; for instance, increased acidity may promote better solvation of the phosphonate moiety.
  • Temperature Influence: Like many other compounds, increased temperature could enhance solubility by increasing molecular motion and disrupting solute-solvent interactions.

In conclusion, the solubility of [5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate will most likely be enhanced in polar environments, making it a versatile compound for formulations that require aqueous solubility. As the great chemist Linus Pauling once noted, “The *correct* structure of a molecule is vital for understanding its chemical properties.” This principle holds true for predicting the solubility of such complex molecules.

Interesting facts

Interesting Facts about [5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

This compound is a fascinating example of how organic chemistry can merge with biochemistry to create molecules that have significant implications in various scientific fields. Here are some highlights:

  • Phosphorylation Potential: The presence of the phosphono group in this compound suggests a potential for phosphorylation, an essential reaction in numerous biological processes, including signal transduction and enzyme activation.
  • Biological Relevance: This compound contains a pyrimidine ring, which is a crucial structural component of nucleotides. Such structures are pivotal for DNA and RNA synthesis, as well as numerous metabolic pathways.
  • Synthetic Pathways: The preparation of this complex molecule can involve creative synthetic strategies. It may include approaches like nucleophilic substitutions and phosphorylation reactions, which are valuable for students and researchers interested in synthetic organic chemistry.
  • Potential Applications: Given its structural components, this compound could have potential applications in medicinal chemistry, especially as a lead compound for drug development targeting nucleic acid processes.
  • Research Interest: Compounds like this spark the interest of chemists and biochemists alike. Their unique structures can lead to discoveries in pharmacology and biochemistry, opening new avenues for research.

As a scientist delving into the complexities of such compounds, one must appreciate the intricate balance of structure and function. The interplay between the molecular architecture and its potential biological activity is what makes the study of such compounds so thrilling.

In the words of a prominent chemist, "The synthesis of complex structures is akin to composing a symphony; each component must harmonize with the others to create a magnificent result."

Synonyms
[5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate
1-{2-Deoxy-5-O-[hydroxy(phosphonooxy)phosphoryl]pentofuranosyl}pyrimidine-2,4(1H,3H)-dione
(5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl)methyl phosphono hydrogen phosphate
1-(2-Deoxy-5-O-(hydroxy(phosphonooxy)phosphoryl)pentofuranosyl)pyrimidine-2,4(1H,3H)-dione
DTXSID90863343