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Tenofovir disoproxil

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Identification
Molecular formula
C19H30N5O10P
CAS number
201341-05-1
IUPAC name
[5-(2,4-dioxopyrimidin-1-yl)-3-fluoro-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate
State
State

Solid at room temperature.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.15
Boiling point (Celsius)
225.60
Boiling point (Kelvin)
498.75
General information
Molecular weight
519.45g/mol
Molar mass
518.4900g/mol
Density
1.4900g/cm3
Appearence

Tenofovir disoproxil appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of [5-(2,4-dioxopyrimidin-1-yl)-3-fluoro-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

The solubility of the compound C19H30N5O10P, commonly known as [5-(2,4-dioxopyrimidin-1-yl)-3-fluoro-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate, exhibits some noteworthy characteristics based on its complex structure.

Key Solubility Characteristics:

  • Polarity: The presence of phosphonate groups typically increases polarity, which can enhance water solubility.
  • Hydrogen Bonding: The compound's ability to form hydrogen bonds due to its functional groups can also favor solubility in polar solvents.
  • Synthetic Variations: Variations in the length and composition of alkyl side chains may influence its solubility profile.

In general, one might expect that:

  • Compounds with higher molecular weights tend to have lower solubility in water.
  • The presence of fluorine atoms can alter solubility in various organic solvents.

In practical terms, researchers often assess solubility in various solvents including aqueous and organic solutions to determine the best conditions for utilization. As such, the solubility of this compound should be evaluated experimentally to provide definitive insights. It is always recommended to refer to specific solubility tests or data for precise applications and formulations.

Interesting facts

Interesting Facts about [5-(2,4-Dioxopyrimidin-1-yl)-3-fluoro-tetrahydrofuran-2-yl]methyl Phosphono Hydrogen Phosphate

This fascinating compound belongs to a class of molecules known as phosphonates, which are characterized by their phosphorus-to-carbon bonding. Here are some intriguing facts about this compound:

  • Biological Relevance: Compounds similar to this one have been studied for their potential use as antiviral agents and in cancer therapy. The integration of pyrimidine and phosphonate functionalities may allow for unique biological interactions.
  • Structural Diversity: The inclusion of a fluorine atom can significantly affect the reactivity and biological properties of the compound. Fluorinated drugs often exhibit enhanced metabolic stability, leading to prolonged activity in biological systems.
  • Mechanistic Insights: This compound utilizes a tetrahydrofuran moiety that may facilitate its role in biochemical pathways, acting as a scaffold for various biological interactions and enzymatic transformations.
  • Phosphorylation Mimics: As a phosphonic acid derivative, this compound can serve as a useful tool in the design of enzyme inhibitors by mimicking the phosphoryl group often found in natural phosphates. This characteristic can be exploited in drug design and development.
  • Research Applications: Due to its complex structure, it is of interest in materials science for developing new polymeric materials and could potentially be used in the synthesis of catalysts.

As scientists explore the myriad of functionalities offered by complex organic compounds such as this, we continue to uncover their potential to impact various fields from medicinal chemistry to polymer science. Understanding the structure-activity relationship of such compounds is key to unlocking new avenues in pharmaceutical design.

Synonyms
PD041026