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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
5-[2,4-dioxo-6-(2,3,4,5-tetrahydroxypentylamino)-1H-pyrimidin-5-yl]pentylphosphonic acid
State
State

At room temperature, Tenofovir is in a solid state, specifically forming as crystalline powder.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
287.22g/mol
Molar mass
287.2160g/mol
Density
1.5000g/cm3
Appearence

The compound appears as a white or off-white crystalline powder. It is often odorless.

Comment on solubility

Solubility of 5-[2,4-dioxo-6-(2,3,4,5-tetrahydroxypentylamino)-1H-pyrimidin-5-yl]pentylphosphonic acid

The solubility of 5-[2,4-dioxo-6-(2,3,4,5-tetrahydroxypentylamino)-1H-pyrimidin-5-yl]pentylphosphonic acid (C9H14N5O4P) presents an intriguing subject within the realm of chemical compounds. Its solubility can be affected by several key factors:

  • Polarity: Due to the presence of multiple hydroxyl groups and the phosphonic acid functionality, this compound is likely to be quite polar, enhancing its solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl groups can engage in strong hydrogen bonding with water molecules, which may significantly increase solubility.
  • pH Dependence: The acidic nature of the phosphonic acid group indicates that its solubility may vary with pH levels, particularly increasing in more alkaline solutions where deprotonation can occur.
  • Temperature Effects: As with many compounds, increasing the temperature may improve solubility, allowing for greater interaction with solvent molecules.

To conclude, it is essential to recognize that the solubility of this compound is influenced by its intricate structure and functional groups. In practical scenarios, one could state that:

"The solubility of this compound in water is expected to be appreciable due to its polar and acidic characteristics."

Overall, understanding these solubility factors not only enhances our appreciation of this compound but also aids in its potential applications in various fields.

Interesting facts

Exploring 5-[2,4-dioxo-6-(2,3,4,5-tetrahydroxypentylamino)-1H-pyrimidin-5-yl]pentylphosphonic acid

This compound, a fascinating member of the phosphonic acid family, presents a unique structure that provides numerous avenues for scientific exploration. It’s notable for its application in medicinal chemistry and agricultural science, largely due to its ability to act as a phosphonate, which can mimic naturally occurring phosphate-containing compounds.

Unique Characteristics

  • Pharmacological Potential: The presence of a pyrimidine ring grants this compound potential as a drug candidate, particularly in the realms of antiviral and anticancer therapies.
  • Hydroxypentyl Chain: The tetrahydroxypentylamino group showcases impressive potential for forming strong interactions with biological targets, which could enhance its effectiveness in therapeutic applications.
  • Phosphonic Acid Group: This group is instrumental in mimicking phosphate groups, thus may influence cellular processes and signaling pathways.

Moreover, compounds of this nature are actively researched for their role in various biological processes. As a chemist, it is fascinating to explore how slight modifications in the molecular structure can lead to vastly different biological activities. In the context of drug development, understanding the structure-activity relationship (SAR) of this compound can provide insights into designing more effective medications.

Quote to Reflect Upon

As noted by renowned chemists, "The beauty of chemistry is in its intricacies; a single atom's rearrangement can lead to revolutionary transformations." This compound embodies that idea, illustrating how specific structural features yield unique properties and potentials.

In conclusion, 5-[2,4-dioxo-6-(2,3,4,5-tetrahydroxypentylamino)-1H-pyrimidin-5-yl]pentylphosphonic acid serves as an excellent example of the diverse and complex nature of chemical compounds. Its applications, especially in pharmaceuticals, make it a compound worth studying and understanding in depth.

Synonyms
PD039789