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Cortisone acetate

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Identification
Molecular formula
C23H30O6
CAS number
50-04-4
IUPAC name
[5-(2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-hydroxy-1,1-dimethyl-4-oxo-hex-2-enyl] acetate
State
State

At room temperature, cortisone acetate is a solid. It is often handled in powder or crystalline form for use in various pharmaceutical formulations.

Melting point (Celsius)
224.00
Melting point (Kelvin)
497.15
Boiling point (Celsius)
362.00
Boiling point (Kelvin)
635.15
General information
Molecular weight
402.48g/mol
Molar mass
402.4790g/mol
Density
1.3070g/cm3
Appearence

Cortisone acetate typically appears as a white or almost white crystalline powder. It is odorless and has a bitter taste. It is usually provided in a pure form used for pharmaceutical purposes.

Comment on solubility

Solubility Overview of [5-(2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-hydroxy-1,1-dimethyl-4-oxo-hex-2-enyl] acetate (C23H30O6)

The solubility of chemical compounds is a critical property that affects their application, reactivity, and interaction with biological systems. In the case of [5-(2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-hydroxy-1,1-dimethyl-4-oxo-hex-2-enyl] acetate, the solubility is shaped by several factors:

  • Molecular Structure: The bulky hydrocarbon rings and multiple hydroxyl (-OH) groups suggest that this compound may have moderate to low solubility in non-polar solvents, while showing improved solubility in polar solvents due to hydrogen bonding.
  • Polarity: The presence of both hydrophobic (non-polar) and hydrophilic (polar) sections within the molecule can lead to a diverse solubility profile, potentially making it soluble in a range of solvents.
  • Functional Groups: With multiple hydroxyl groups, the compound is likely to engage in hydrogen bonding, which could enhance its solubility in water and alcohols.

It's often stated that "like dissolves like," meaning that polar solvents generally dissolve polar solutes, while non-polar solvents dissolve non-polar solutes. Therefore, the solubility of this compound may depend significantly on the solvent choice:

  • Polar solvents: Such as water and alcohols may dissolve the compound better due to hydrogen bonding.
  • Non-polar solvents: Such as hexane or toluene, are less likely to dissolve this compound effectively.

In conclusion, to fully assess the solubility of [5-(2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-hydroxy-1,1-dimethyl-4-oxo-hex-2-enyl] acetate, experimental solubility tests in various solvents should be conducted. Observing its behavior under different conditions will provide insight into its practical applications in pharmaceutical and chemical formulations.

Interesting facts

Exploring the Compound: 5-(2,16-Dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-hydroxy-1,1-dimethyl-4-oxo-hex-2-enyl acetate

This intriguing chemical compound belongs to a class of complex organic molecules that are rich in functional groups. Here are some fascinating aspects to consider:

  • Natural Product Derivative: The structure resembles that of natural steroids, hinting at possible biological activity similar to hormones or pharmaceuticals.
  • Structural Complexity: With multiple hydroxy groups and an extensive hydrocarbon backbone, this compound showcases the marvels of organic synthesis.
  • Potential Applications: The presence of a dimethyl and multiple carbonyl groups suggests potential uses in medicinal chemistry, possibly as a precursor for drug development.
  • Impact of Substituents: The distinct arrangement of methyl and hydroxyl groups could significantly influence the compound's pharmacokinetics, affecting how it interacts within a biological system.
  • Environmental Relevance: Understanding such compounds might lead to insights in biochemistry related to plant hormones or signaling molecules that play a role in various ecological systems.

In the words of renowned chemist Robert H. Grubbs, "The synthesis of complex molecules is a testament to human ingenuity." This compound is a perfect example of that ingenuity, blending structural diversity and functional potential.

Overall, the exploration of this chemical not only emphasizes the beauty of organic chemistry but also invites further investigation into its potential applications and implications in biological systems.

Synonyms
6-{2,8-dihydroxy-3a,6,6,9b,11a-pentamethyl-7,10-dioxo-1H,2H,3H,3bH,4H,8H,9H,9aH,11H-cyclopenta[a]phenanthren-1-yl}-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate