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Clotiazepam

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Identification
Molecular formula
C16H15ClN2OS
CAS number
33671-46-4
IUPAC name
5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one
State
State

At room temperature, clotiazepam is generally in a solid form as it is a crystalline powder.

Melting point (Celsius)
186.00
Melting point (Kelvin)
459.15
Boiling point (Celsius)
770.00
Boiling point (Kelvin)
1 043.15
General information
Molecular weight
353.82g/mol
Molar mass
353.8440g/mol
Density
1.5000g/cm3
Appearence

Clotiazepam is usually found as a crystalline powder that appears white to off-white in color. It is often supplied in the form of tablets or capsules for pharmaceutical use.

Comment on solubility

Solubility of 5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one (C16H15ClN2OS)

The solubility of chemical compounds plays a crucial role in their therapeutic and practical applications. For 5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one, understanding its solubility characteristics can provide insights into its reactivity and accessibility in various solvents. Here are some key points regarding its solubility:

  • Polar solvents: Compounds with polar functional groups tend to be soluble in polar solvents. However, due to the presence of chlorine and a thieno moiety, this compound may exhibit limited solubility in water.
  • Non-polar solvents: It is likely to demonstrate higher solubility in non-polar solvents, which can better stabilize the hydrophobic parts of the molecule.
  • pH influence: Changes in pH can considerably impact the solubility of the compound, especially if it contains any acidic or basic sites that can ionize.

As a general rule, the solubility can be summarized with the phrase, "like dissolves like." This means that a compound will be more soluble in solvents that have similar polarity. Therefore, the exploration of solubility for C16H15ClN2OS is fundamental for its application in medicinal chemistry and formulation science.

Interesting facts

Interesting Facts about 5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one

5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one is a fascinating compound within the realm of medicinal chemistry. Here are some key insights:

  • Pharmacological Significance: This compound belongs to the diazepine class, which is known for its sedative and anxiolytic properties.
  • Structural Diversity: The presence of the thieno ring system enhances the structural uniqueness of this compound, contributing to its bioactivity.
  • Chlorine Substitution: The introduction of a chlorine atom in the phenyl group often influences the compound's reactivity and potency, making it an interesting subject for structure-activity relationship (SAR) studies.
  • Emerging Research: Compounds like this one are being explored for potential applications in treating various neurological disorders, including anxiety and insomnia.

As a chemist, the integration of the thieno ring with the diazepine framework not only proposes intriguing synthetic pathways but also highlights the significance of heterocycles in drug design. In the words of a famed chemist, "Structure dictates function," and this compound is a prime example of how molecular architecture reflects intended biological activity.

In conclusion, 5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one represents the exciting intersection of organic chemistry and pharmacology, sparking curiosity for further exploration in therapeutic contexts.

Synonyms
clotiazepam
Rize
Trecalmo
Rizen
Tienor
33671-46-4
Rise
Clotiazepamum [INN-Latin]
Clotiazepamum
Distensan
Clozan
Clotiazepam [INN:JAN]
Y 6047
EINECS 251-627-3
5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one
BRN 0623332
5-(o-Chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2H-thieno(2,3-e)-1,4-diazepin-2-one
ZCN055599V
CLOTIAZEPAM [MI]
5-(2-Chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one
CLOTIAZEPAM [INN]
CLOTIAZEPAM [JAN]
Y-6047
CLOTIAZEPAM [MART.]
CLOTIAZEPAM [WHO-DD]
2H-Thieno(2,3e)(1,4)-diazepin-2-one, 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
DTXSID0022852
2H-Thieno(2,3-e)(1,4)diazepin-2-one, 1,3-dihydro-5-(o-chlorophenyl)-7-ethyl-1-methyl-
5-(2-chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepin-2-one
Veratran
Clotiazepamum (INN-Latin)
2H-Thieno(2,3-e)-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
2H-Thieno[2,3-e]-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
CLOTIAZEPAM (MART.)
Clotiazepam (1 mg/mL in Methanol)
5-(2-chlorophenyl)-7-ethyl-1-methyl-1H,2H,3H-thieno[2,3-e][1,4]diazepin-2-one
Clotiazepam (1.0mg/ml in Acetonitrile)
Rize (TN)
UNII-ZCN055599V
DEA No. 2752
5-(2-chlorophenyl)-7-ethyl-1-methyl-1H,2H,3H-thieno(2,3-e)(1,4)diazepin-2-one
Y6047
Clotiazepam (JP17/INN)
SCHEMBL44592
DTXCID102852
CHEMBL1697737
CHEBI:31425
Clotiazepam, 1mg/ml in Methanol
N05BA21
HY-U00317
AKOS005065735
CS-7319
DB01559
2H-Thieno(2,3e)(1,4)-diazepin-2-one, 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-(8CI)
NS00009354
D01328
Q2263999
2H-Thieno[2,3-E]-1,4-diazepine-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
251-627-3