Skip to main content

Triazole Derivative

ADVERTISEMENT
Identification
Molecular formula
C19H18Cl2N6O2
CAS number
123456-78-9
IUPAC name
5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1,2,4-triazole-3-carboxamide
State
State

At room temperature, the compound is generally found as a crystalline solid. It is stable under usual laboratory conditions.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
380.00
Boiling point (Kelvin)
653.15
General information
Molecular weight
453.92g/mol
Molar mass
453.9230g/mol
Density
1.4500g/cm3
Appearence

This compound typically appears as a white to off-white solid powder. Its physical state and dustiness can vary depending on the method of synthesis and storage conditions.

Comment on solubility

Solubility of 5-[[[2-aminoacetyl]amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1,2,4-triazole-3-carboxamide

The solubility of the compound with the formula C19H18Cl2N6O2 can be considered based on its molecular structure and functional groups present. This compound features multiple polar functionalities that potentially influence its solubility characteristics:

  • Amide Groups: The presence of amide functional groups is generally associated with increased solubility in polar solvents, due to their ability to form hydrogen bonds.
  • Chlorine Atoms: The chlorine substituents can affect the overall polarity and hydrophobic character of the molecule, which may lead to complex solubility behaviors.
  • Triazole Ring: This heterocyclic moiety often exhibits varied solubility depending on the substituents attached and interactions with the solvent.

In general, solubility may vary significantly with the solvent used. Water solubility is often influenced by:

  1. Hydrogen Bonding: Better solubility in water if the compound can engage in extensive hydrogen bonding.
  2. Hydrophobic Regions: Compounds with substantial hydrophobic regions may find reduced solubility in water.
  3. Temperature Effects: Solubility may increase with temperature, especially in organic solvents.

In practical terms, to ascertain the solubility of this compound conclusively, experimental methods such as solubility tests in various solvents under controlled conditions would be essential. Understanding the solubility can aid in applications related to drug formulation, environmental impact assessments, and chemical synthesis.

Interesting facts

Interesting Facts about 5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1,2,4-triazole-3-carboxamide

This intriguing compound belongs to the class of triazole derivatives, which are well-known for their diverse pharmacological properties. Here are some fascinating aspects worth noting:

  • Triazole Backbone: The triazole ring in this compound provides unique biological activities, making it a topic of research in medicinal chemistry, particularly in the development of antifungal and antitumor agents.
  • Amide Linkage: The presence of an amide functional group contributes significantly to the compound's stability and potential interactions with biological macromolecules, enhancing its efficacy as a pharmaceutical agent.
  • Chlorine Substituents: The chlorinated aromatic rings not only influence the compound's lipophilicity but also modify its binding affinity in biological systems, which can be crucial for its biological activity.

Potential Applications

This compound has drawn interest for various potential applications, including:

  • Medical Research: Its structure suggests activity against various pathogens, making it a candidate for further studies in infectious disease treatment.
  • Agricultural Chemistry: Similar triazole compounds are often investigated for their role in crop protection, highlighting the versatile applications of this class of compounds.
  • Drug Design: Understanding the structure-activity relationship (SAR) can guide the development of more effective derivatives for therapeutic use.

In summary, this compound embodies a fascinating intersection of synthetic chemistry and biological activity, making it a valuable subject for both academic inquiry and practical applications. As research progresses, its unique properties may lead to significant breakthroughs in drug development and other fields.

Synonyms
Rilmazafone
99593-25-6
Rilmazafone [INN]
Rilmazafona
5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1,2,4-triazole-3-carboxamide
99593-25-6 free base)
CU3H37T766
Rilmazafone (INN)
Rilmazafonum [Latin]
Rilmazafona [Spanish]
Rilmazafonum
1H-1,2,4-Triazole-3-carboxamide,5-[[(aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-
UNII-CU3H37T766
RILMAZAFONE [MI]
RILMAZAFONE [WHO-DD]
SCHEMBL123946
CHEMBL2107197
DTXSID10244150
CHEBI:135767
EX-A5707
AKOS016014131
1H-1,2,4-Triazole-3-carboxamide, 5-(((aminoacetyl)amino)methyl)-1-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N,N-dimethyl-
1H-1,2,4-Triazole-3-carboxamide, 5-(((aminoacetyl)amino)methyl)-1-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N,N-dimethyl-, monohydrochloride
5-((2-Aminoacetamido)methyl)-1-(4-chloro-2-(o-chlorobenzoyl)phenyl)-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide
DA-57446
HY-106547
CS-0026029
D08481
Q7334297