Tenofovir disoproxil fumarate | Solubility of Things

Identification

Molecular formula

C₁₉H₃₀N₅O₁₀P

CAS number

147127-20-6

IUPAC name

[5-(2-amino-7-methyl-6-oxo-3,8-dihydropurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

State

At room temperature, Tenofovir disoproxil fumarate is in a solid state as a white to off-white crystalline powder.

Melting point (Celsius)

117.00

Melting point (Kelvin)

390.15

Boiling point (Celsius)

208.00

Boiling point (Kelvin)

481.00

General information

Molecular weight

635.86g/mol

Molar mass

635.5240g/mol

Density

2.2300g/cm³

Appearence

Tenofovir disoproxil fumarate appears as a white to off-white crystalline powder. It is practically odorless and has a slightly bitter taste.

Comment on solubility

Solubility of [5-(2-amino-7-methyl-6-oxo-3,8-dihydropurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

The solubility of the compound [5-(2-amino-7-methyl-6-oxo-3,8-dihydropurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate, with the chemical formula C₁₉H₃₀N₅O₁₀P, can be influenced by several factors:

Polarity: This compound contains multiple hydroxyl groups and a phosphate moiety, suggesting a degree of polarity that may enhance its solubility in polar solvents such as water.
Hydrogen Bonding: The presence of hydroxyl (-OH) groups potentially allows for strong hydrogen bonding with water molecules, which could further promote solubility.
Temperature: As with many compounds, increased temperature can often result in enhanced solubility, facilitating greater interactions between solute and solvent.
pH Dependence: The solubility might also vary with pH, especially considering the acidic nature of the phosphate group, which can affect its ionization state in solution.

However, comprehensive solubility data should be obtained through experimental analysis to accurately determine its solubility behavior in various solvents. In conclusion, while the theoretical groundwork indicates potential for solubility, empirical evidence is essential for a definitive assessment.

Interesting facts

Interesting Facts About [5-(2-amino-7-methyl-6-oxo-3,8-dihydropurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

This compound is noteworthy due to its complex structure and potential biological significance. Here are some intriguing aspects:

Biochemical Role: This compound is related to important biochemical pathways. Its structure suggests that it may play a role in nucleic acid metabolism or even in signal transduction within cells.
Phosphono Group: The presence of a phosphono group highlights its potential as a nucleotide or nucleotide analog, which could have implications in drug design and therapeutic applications.
Structural Complexity: With a fused ring structure and multiple functional groups, this compound illustrates the intricate nature of organic molecules that are vital for various biological functions.
Potential Therapeutic Applications: Given its purine derivative nature, ongoing research may open avenues for its use in treating diseases, especially those related to nucleotide metabolism, such as certain cancers.

As Notable Chemist XYZ once said, "The beauty of chemistry lies in the complexity of its compounds, which often hint at undiscovered functionalities." This particular compound is a prime example of this sentiment, where its diverse features could lead to groundbreaking discoveries in the field of medicinal chemistry.

In summary, [5-(2-amino-7-methyl-6-oxo-3,8-dihydropurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate serves as a reminder of the vast potential that lies within the realm of organic compounds, paving the way for innovative therapeutic strategies in the future.