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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
[[[5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]methylphosphonic acid
State
State

At room temperature, Tenofovir is typically in a solid crystalline state. It is generally supplied as a salt form for use in oral medication formulations, where it becomes more stable and readily absorbed.

Melting point (Celsius)
276.50
Melting point (Kelvin)
549.70
Boiling point (Celsius)
611.10
Boiling point (Kelvin)
884.30
General information
Molecular weight
287.21g/mol
Molar mass
287.2140g/mol
Density
1.4974g/cm3
Appearence

Tenofovir is a white to off-white, crystalline powder. It is commonly provided as a prodrug form called tenofovir disoproxil fumarate, which is also white to off-white in appearance and is more stable and soluble.

Comment on solubility

Solubility of 5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl methoxy-hydroxy-phosphoryl oxy-hydroxy-phosphoryl methylphosphonic acid

The solubility of the compound with the chemical formula C9H14N5O4P is an intriguing topic due to its structural complexity. Here are some important considerations regarding its solubility:

  • Hydrophilicity: The presence of multiple hydroxyl groups (-OH) and phosphorus-containing moieties typically enhances water solubility. Compounds with such polar functional groups are often more soluble in aqueous environments.
  • Interactions: This compound may exhibit strong hydrogen bonding capabilities, which can further facilitate its dissolution in water by interacting with solvent molecules.
  • Solvent Effects: While it is likely soluble in polar solvents like water, this compound's solubility may vary significantly in non-polar solvents due to its complex structure and the nature of its functional groups.

In summary, it is expected that this compound will demonstrate a favorable solubility profile in polar solvents, primarily due to the influence of its numerous hydrophilic features. Understanding the solubility behavior is crucial for applications in medicinal chemistry and biochemical research, as solubility can dramatically affect bioavailability and reactivity.

Interesting facts

Interesting Facts about 5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]methylphosphonic acid

This compound is a fascinating example of the intersection between organic chemistry and biochemistry. It belongs to a class of compounds known as nucleoside analogs. Here are some interesting facts:

  • Biodiversity Role: Compounds like this frequently play essential roles in biological systems, particularly in the realm of cellular signaling.
  • Potential Therapeutic Uses: Nucleoside analogs are often explored for their potential in treating viral infections and cancer due to their ability to inhibit replication mechanisms.
  • Chemical Complexity: This compound showcases intricate structural features, including a purine base and several hydroxyl and phosphate groups, making it a candidate for detailed studies in medicinal chemistry.
  • Enzymatic Interactions: It may interact with various enzymes, which can lead to significant biological consequences as its structure mimics natural substrates.

In the words of a notable chemist, "The beauty of organic chemistry lies in its complexity and its ability to mirror life itself." This compound is a prime example of this beauty, as its structure allows it to participate in critical biochemical pathways and provides a playground for researchers seeking to innovate therapeutic strategies.


In summary, the intricate structure and potential applications of this compound underscore the essential role that chemical compounds play in advancing our understanding of biological processes and the treatment of diseases. It serves as a reminder of how chemistry is at the heart of life itself.