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Adefovir

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Identification
Molecular formula
C10H15N5O4P
CAS number
106941-25-7
IUPAC name
[[[[5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]amino]phosphonic acid
State
State

At room temperature, Adefovir is present in a solid state. Its stability and solid form at ambient conditions make it suitable for various pharmaceutical formulations, typically administered as tablets or capsules in its prodrug form.

Melting point (Celsius)
275.00
Melting point (Kelvin)
548.15
Boiling point (Celsius)
920.00
Boiling point (Kelvin)
1 193.15
General information
Molecular weight
501.21g/mol
Molar mass
501.2080g/mol
Density
2.3000g/cm3
Appearence

Adefovir is typically available in the form of a crystalline powder. The compound is white or off-white in appearance and is often found in its salt form for pharmaceutical applications. It is hygroscopic, readily absorbing moisture from the environment.

Comment on solubility

Solubility of 5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]amino]phosphonic acid

The solubility of the compound C10H15N5O4P, known as 5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]amino]phosphonic acid, is quite intriguing. This compound exhibits several notable characteristics in terms of solubility:

  • Highly soluble in polar solvents: The presence of hydroxyl (-OH) and amino (-NH2) groups greatly enhances its ability to dissolve in polar solvents, such as water.
  • Limited solubility in non-polar solvents: Due to its highly ionic and polar nature, the compound shows poor solubility in non-polar solvents like hexane or chloroform.
  • pH dependence: The solubility can vary depending on the pH of the solution, with increased solubility usually observed in acidic conditions because of protonation of basic sites, allowing for better interaction with water molecules.
  • Impact of temperature: As is typical with many biochemical compounds, increasing the temperature may promote greater solubility due to enhanced molecular motion.

In conclusion, the solubility profile of this compound can be summarized as follows:

  1. Highly soluble in polar solvents.
  2. Poorly soluble in non-polar solvents.
  3. Influenced by solution pH.
  4. Temperature can enhance solubility.

Overall, understanding the solubility of this complex compound is crucial for its practical applications in various biochemical and pharmaceutical fields.

Interesting facts

Interesting Facts about 5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]amino]phosphonic acid

5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]amino]phosphonic acid is a fascinating compound within the realm of biochemical research, primarily due to its structural complexity and biological significance.

Key Features:

  • Biological Role: This compound plays a crucial role in the metabolism of nucleotides and has implications in the synthesis of essential biomolecules.
  • Mechanism of Action: It is known to influence various enzymatic activities and is a substrate for many important biochemical pathways.
  • Pharmaceutical Potential: Due to its intricate structure, it has garnered interest for potential applications in drug development, particularly in targeting certain diseases at the molecular level.

One remarkable aspect of this compound is its origin from naturally occurring molecules involved in DNA and RNA synthesis. As a phosphonic acid derivative, it provides unique functionalities compared to traditional organic acids, enhancing its potential utility in medicinal chemistry.

Quote:

As one researcher put it, "Understanding the roles specific compounds like this play in the biochemical landscape could unlock new therapies and deepen our comprehension of cellular mechanics."

This compound exemplifies the intricate interplay of various biochemical processes, emphasizing the importance of ongoing research in chemical science to elucidate the subtleties of biomolecular interactions.