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Tenofovir disoproxil

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Identification
Molecular formula
C9H15N5O4P
CAS number
147127-20-6
IUPAC name
[[5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] dihydroxyphosphinothioyl hydrogen phosphate
State
State

Tenofovir disoproxil is typically available in solid form at room temperature. It is stable under normal conditions and should be protected from light and moisture when stored.

Melting point (Celsius)
260.00
Melting point (Kelvin)
533.15
Boiling point (Celsius)
840.00
Boiling point (Kelvin)
1 113.15
General information
Molecular weight
287.22g/mol
Molar mass
287.2170g/mol
Density
1.4950g/cm3
Appearence

Tenofovir disoproxil is a white to off-white crystalline powder. It is usually provided in the form of a prodrug, tenofovir disoproxil fumarate (TDF), for better oral bioavailability. It is often found in a tablet or capsule form as a medication.

Comment on solubility

Solubility of [5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl dihydroxyphosphinothioyl hydrogen phosphate

The solubility of the compound with the chemical formula C9H15N5O4P can be a complex topic due to its intricate structure. Here are some important points to consider regarding its solubility:

  • Polarity: This compound contains multiple functional groups that contribute to its overall polarity, affecting its solubility in various solvents.
  • Water Solubility: Given the presence of hydroxyl (-OH) groups, one might expect some degree of solubility in water, yet the effectiveness depends on the balance of hydrophilic and hydrophobic characteristics.
  • Organic Solvents: Solubility may increase in polar organic solvents such as dimethyl sulfoxide (DMSO) or methanol, where its structural components can interact favorably with solvent molecules.
  • pH Sensitivity: The solubility could also be influenced by pH levels, with some compounds exhibiting higher solubility in acidic or basic conditions due to ionization.

In conclusion, while the compound is likely to exhibit some solubility in water, the exact degree will depend on solvent conditions, ionic interactions, and pH. It’s essential to conduct empirical tests to determine its solubility in various environments for practical applications.

Interesting facts

Interesting Facts about [5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl dihydroxyphosphinothioyl hydrogen phosphate

This complex compound, commonly associated with biochemical processes, has fascinating attributes and implications in the realm of molecular biology and organic chemistry. Below are some intriguing facts about it:

  • Biological Relevance: The compound features a purine base, which is a critical component of nucleotides, the building blocks of DNA and RNA. Its structure suggests significant roles in cellular processes such as signaling and energy transfer.
  • Phosphorylation Potential: Phosphorylated compounds are essential in the regulation of many cellular functions. This compound's phosphoryl moiety implies it could participate in various phosphorylation reactions crucial for metabolic pathways.
  • Thioether Linkage: The presence of a thioyl group indicates potential reactivity and interactions with biological molecules, showcasing how sulfur can be integrated into organic structures to modify characteristics and reactivity.
  • Medicinal Implications: Compounds similar in structure are often explored for their pharmacological properties. This specific molecule could be significant in developing therapeutics targeting various diseases, including cancer and viral infections.
  • Complexity and Synthesis: The intricately branched structure requires advanced synthetic strategies for its preparation, making it a subject of interest in synthetic organic chemistry.

In summary, the intricate structure and functionality of this compound exemplify the intersection of chemistry and biochemistry. As noted by renowned chemist Linus Pauling, “The greatest secrets are always hidden in the most unlikely places.” This complex molecule is an excellent example of how hidden potential within chemical compounds can lead to groundbreaking discoveries in science.