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Adefovir dipivoxil

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Identification
Molecular formula
C20H32N5O8P
CAS number
106941-25-7
IUPAC name
[5-(2-amino-6-oxo-3H-purin-9-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate
State
State

At room temperature, Adefovir dipivoxil is in a solid state. It is a crystalline powder often used in pharmaceutical applications, especially for treating certain types of hepatitis.

Melting point (Celsius)
279.00
Melting point (Kelvin)
552.00
Boiling point (Celsius)
100.00
Boiling point (Kelvin)
373.15
General information
Molecular weight
501.48g/mol
Molar mass
501.4560g/mol
Density
2.5100g/cm3
Appearence

Adefovir dipivoxil is typically a white to off-white powder. It should be stored in well-sealed containers, protected from moisture and light.

Comment on solubility

Solubility of [5-(2-amino-6-oxo-3H-purin-9-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

The solubility of the compound C20H32N5O8P can be evaluated based on its structural and chemical characteristics. Factors influencing solubility include:

  • Polarity: The presence of multiple functional groups, including phosphate, contributes to a high degree of polarity.
  • Hydrogen bonding: The compound's ability to form hydrogen bonds can enhance solubility in polar solvents like water.
  • Size: The size of the molecule may impede solubility in some organic solvents, while permitting easier dissolution in others.

Generally, polar compounds tend to be more soluble in polar solvents. In the case of this compound:

  • It is expected to be soluble or at least partially soluble in aqueous solution.
  • However, solubility might decrease in non-polar organic solvents due to the incompatibility of polar structures.

It's essential to note that empirical testing is often required to confirm the solubility characteristics, as theoretical predictions may not always capture the complexities of solvation dynamics. Researchers should consider the temperature and pH of the solution, which can significantly affect the solubility of such complex molecules.

Interesting facts

Interesting Facts about [5-(2-amino-6-oxo-3H-purin-9-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

This fascinating compound is a complex molecule that belongs to the class of phosphoramidates and carries significant biological relevance, particularly in the realm of biochemistry and molecular biology. Here are some key points to consider:

  • Biological Significance: Known for its role in nucleotide metabolism, this compound can be considered as a potential analog of nucleotide substrates. It plays a critical role in the synthesis of nucleotides, which are the building blocks of DNA and RNA.
  • Structure Complexity: The presence of both purine and tetrahydrofuran moieties in its structure suggests interesting interactions and functionalities. These components may contribute to the compound's ability to engage with biological targets.
  • Potential Therapeutic Applications: Given its structure, this compound holds promise in the design of new pharmaceuticals, especially in targeting viral and bacterial replication processes.
  • Catalytic Properties: Some studies suggest that similar compounds may exhibit catalytic properties, potentially acting as inhibitors or activators of certain enzymatic pathways in cellular processes.
  • Research Relevance: This compound stretches the boundaries of drug design and molecular biology. Researchers are continually exploring its potential in the development of innovative therapies against diseases linked to nucleotide enzymatic functions.

In conclusion, [5-(2-amino-6-oxo-3H-purin-9-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate is more than just a chemical compound; it’s a nexus point where chemistry meets biology. As we uncover more about its properties, the possibilities for applications in pharmacology and biotechnology could be transformative.