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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
201341-05-1
IUPAC name
[5-(2-amino-4-oxo-1,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-pyrrolidin-2-yl]methyl dihydrogen phosphate
State
State

At room temperature, tenofovir is generally found in a solid state as a crystalline powder. It has a relatively high melting point, which contributes to its solid state under standard conditions.

Melting point (Celsius)
276.20
Melting point (Kelvin)
549.35
Boiling point (Celsius)
313.98
Boiling point (Kelvin)
587.13
General information
Molecular weight
287.21g/mol
Molar mass
287.2110g/mol
Density
1.4900g/cm3
Appearence

Tenofovir is typically found as a white to off-white crystalline powder. It is soluble in water at 13.4 mg/mL. As a free base, tenofovir is a white crystalline substance that is somewhat hygroscopic.

Comment on solubility

Solubility of [5-(2-amino-4-oxo-1,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-pyrrolidin-2-yl]methyl dihydrogen phosphate

The solubility of the compound [5-(2-amino-4-oxo-1,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-pyrrolidin-2-yl]methyl dihydrogen phosphate, with the chemical formula C9H14N5O4P, showcases some fascinating characteristics. Understanding its solubility can be essential for its applications in various fields, especially in pharmacology and biochemistry. Consider the following key points regarding its solubility:

  • Polarity: Due to the presence of multiple hydrophilic functional groups such as –OH and –NH2, the compound is likely to have high solubility in polar solvents, especially water.
  • Hydrogen Bonding: The potential for extensive hydrogen bonding interactions with water molecules significantly enhances its solubility.
  • Conformation: The structural conformation influenced by the cyclic components may also play a role in how well the compound dissolves.
  • pH Sensitivity: The solubility may vary with changes in pH, as certain functional groups can ionize, further increasing interaction with the solvent.

It is often said that “Like dissolves like,” and in this compound’s case, its various functional groups make it quite compatible with polar solvents. Overall, while empirical data on the exact solubility may be limited, the structural features indicate a tendency towards significant solubility in aqueous solutions.

Interesting facts

Interesting Facts about [5-(2-amino-4-oxo-1,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-pyrrolidin-2-yl]methyl dihydrogen phosphate

This compound is truly fascinating due to its unique structure and potential applications. The compound features a complex molecular framework that includes:

  • Amino acids derived structure: It contains amino groups that play an important role in biological processes, potentially enhancing its interaction with biological molecules.
  • Phosphate group: The presence of a dihydrogen phosphate moiety suggests important implications in energy transfer and cellular signaling within biochemical systems.
  • Dihydropyrrolo-pyrimidine scaffold: This structural motif is known for various pharmacological activities, making it a point of interest in medicinal chemistry.

The intricate arrangement of the nitrogen-containing rings also signifies a possibility for developing novel pharmaceutical agents. Researchers are particularly excited about the following aspects:

  • Potential therapeutic uses: Compounds like this one can exhibit anti-cancer, anti-viral, or anti-bacterial properties, depending on their interactions with biological targets.
  • Novel synthesis strategies: The synthesis of such complex molecules often involves innovative organic chemistry techniques, which can expand our understanding of chemical reactivity and synthesis.
  • Structure-activity relationship (SAR): Investigating how modifications to this compound's structure affect its biological activity can provide invaluable knowledge for drug design.

In conclusion, [5-(2-amino-4-oxo-1,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-pyrrolidin-2-yl]methyl dihydrogen phosphate serves as a remarkable example of the intersection between organic chemistry and pharmacology. As researchers delve deeper into its properties, the potential for discovering groundbreaking applications in medicine expands.