Skip to main content

Tetrahydropalmatine

ADVERTISEMENT
Identification
Molecular formula
C21H25NO4
CAS number
2934-97-6
IUPAC name
(4S,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
State
State

At room temperature, tetrahydropalmatine is typically found in a solid state, often as a crystalline powder.

Melting point (Celsius)
149.00
Melting point (Kelvin)
422.15
Boiling point (Celsius)
298.00
Boiling point (Kelvin)
571.15
General information
Molecular weight
355.43g/mol
Molar mass
355.4100g/mol
Density
1.3400g/cm3
Appearence

Tetrahydropalmatine appears as a white to off-white crystalline powder. It may also be available in the form of tablets or capsules when used as a supplement.

Comment on solubility

Solubility of (4S,4aS,7aR,12bS)-4a-Hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

The solubility of complex organic compounds such as (4S,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one can be influenced by several factors:

  • Polarity: The compound contains both hydroxyl (-OH) and methoxy (-OCH3) groups, which tend to increase its polar character. This feature can make it more soluble in polar solvents such as water or methanol.
  • Hydrophobic regions: The presence of multiple hydrophobic alkyl groups and aromatic rings may contribute to lower solubility in polar solvents, potentially favoring solubility in organic solvents like chloroform or ethanol.
  • pH Dependence: The solubility of compounds with functional groups like hydroxyl can be pH-dependent. Variations in acidity can alter the ionization state of the compound, thereby affecting its solubility in aqueous solutions.
  • Crystal structure: The specific arrangement of atoms and the stability of the solid form can also significantly impact solubility. Highly ordered crystal lattices typically exhibit lower solubility due to strong intermolecular forces.

In conclusion, understanding the solubility characteristics of (4S,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one requires a consideration of its chemical structure and interactions in various solvent environments. A thorough investigation of its solubility profile could provide insights into its potential applications in pharmaceutical formulations or organic synthesis.

Interesting facts

Interesting Facts about (4S,4aS,7aR,12bS)-4a-Hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

This compound belongs to a fascinating class of chemicals known as isoquinolines, which are noted for their complex ring structures and significant biological activities. With its intricate molecular architecture, this specific isoquinoline derivative showcases unique features that are of great interest to researchers. Here are some highlights:

  • Natural Product Origins: Compounds like this often exhibit natural origins, being derived from plants and other organisms. They can possess numerous medicinal properties, ranging from anti-inflammatory to anti-cancer activities.
  • Structural Complexity: The multi-ring structure of this compound poses intriguing challenges for chemists when it comes to synthesis and modification. The specific configuration of stereocenters (as indicated by the S and R designations) plays a critical role in its biological activity.
  • Potential Pharmacological Effects: Chemical structures similar to this compound have been studied for their potential effects on the central nervous system and may exhibit neuroprotective properties.
  • Research Applications: This compound can serve as a lead structure in drug discovery, prompting further investigation into its synthesis, modification, and potential therapeutic usages.

As chemists continue to explore the vast world of isoquinoline derivatives, this compound stands out as an exemplary candidate for studying advanced pharmacological interactions and the subtleties of molecular function. With ongoing research, it is possible that novel applications may emerge, showcasing the relevance of complex compounds in medicinal chemistry.