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Pyrimethamine

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Identification
Molecular formula
C12H13ClN4
CAS number
58-14-0
IUPAC name
4,7-diamino-N-(2-morpholinoethyl)-2-phenyl-pteridine-6-carboxamide
State
State

At room temperature, pyrimethamine is a solid. It is stable under normal temperatures and pressures. Due to its stability, it is commonly used in tablet form for medicinal purposes.

Melting point (Celsius)
233.80
Melting point (Kelvin)
506.90
Boiling point (Celsius)
495.40
Boiling point (Kelvin)
768.60
General information
Molecular weight
248.71g/mol
Molar mass
248.7070g/mol
Density
1.4400g/cm3
Appearence

Pyrimethamine appears as an off-white to yellow crystalline powder. It is typically very finely powdered for pharmaceutical use. The color may vary slightly depending on the specific formulation or the presence of impurities.

Comment on solubility

Solubility of 4,7-Diamino-N-(2-morpholinoethyl)-2-phenyl-pteridine-6-carboxamide

The solubility of the compound 4,7-diamino-N-(2-morpholinoethyl)-2-phenyl-pteridine-6-carboxamide, with the chemical formula C12H13ClN4, can be influenced by various factors such as temperature, pH, and the presence of solvents. Understanding the solubility characteristics of this compound is crucial in a variety of applications, particularly in pharmaceuticals and chemical research.

Key Considerations Regarding Solubility:

  • Polarity: This compound’s solubility may vary significantly based on its polar and non-polar interactions. Compounds with functional groups that can hydrogen bond often exhibit higher solubility in polar solvents.
  • pH Dependency: The solubility of many biological and pharmaceutical compounds can be greatly affected by pH levels. In acidic or basic conditions, protonation or deprotonation of certain functional groups can enhance solubility.
  • Common Solvents: While specific solubility data might not be readily available, compounds containing amine groups typically have better solubility in water and ethanol compared to non-polar solvents.
  • Temperature Influence: Generally, increasing the temperature can enhance the solubility of most solids in liquids, but this could vary based on specific interactions within the compound.

In summary, understanding the solubility behavior of this complex compound is essential for its effective application. Investigating different solvents and conditions will provide insights into its practical usability in various chemical processes.

Interesting facts

Interesting Facts about 4,7-Diamino-N-(2-morpholinoethyl)-2-phenyl-pteridine-6-carboxamide

The compound 4,7-diamino-N-(2-morpholinoethyl)-2-phenyl-pteridine-6-carboxamide is quite fascinating and showcases a range of intriguing properties.

1. Structural Complexity

This compound is notable for its complex structure, which features:

  • A pteridine core, an important bicyclic structure in various biological systems.
  • A morpholino group, which enhances its solubility and biological activity.
  • Multiple amino groups that can participate in hydrogen bonding, potentially influencing its behavior in biological systems.

2. Biological Significance

Compounds like this one often have potential applications in pharmacology:

  • Anticancer Activity: Pteridine derivatives are frequently studied for their role in cancer treatments.
  • Enzyme Inhibition: The presence of amino groups suggests it may interact with various enzymes, potentially acting as a modulator.

3. Potential Research Areas

This compound may lead to interesting studies in various fields:

  • Medicinal Chemistry: Its unique structure is a valuable lead compound for the development of new drugs.
  • Biochemistry: Understanding its interactions in biological systems can shed light on metabolic pathways.

4. Synthesis and Applications

The synthesis of this compound can provide insights into:

  • Reaction Mechanisms: The synthesis pathway often involves complex reaction conditions which can be a great learning opportunity for chemistry students.
  • Targeted Drug Delivery: Understanding how the morpholino group affects the compound's uptake in cells can contribute to advancements in drug delivery systems.

In conclusion, 4,7-diamino-N-(2-morpholinoethyl)-2-phenyl-pteridine-6-carboxamide is more than just a chemical compound; it's a gateway to understanding deeper biological processes and developing innovative therapeutic strategies. As one researcher put it, "The complexity of chemical structures often holds the keys to breakthroughs in science." This compound is certainly a testament to that belief.

Synonyms
WY-3654
61-69-8
849EPU19LD
BRN 0590858
UNII-849EPU19LD
6-Pteridinecarboxamide, 4,7-diamino-N-(2-morpholinoethyl)-2-phenyl-
WY 3654
4,7-diamino-N-(2-morpholin-4-ylethyl)-2-phenylpteridine-6-carboxamide
4,7-Diamino-N-(2-(4-morpholino)-ethyl)-2-phenyl-6-pteridine-carboxamide
DTXSID60976474
Q27269508
4,7-Di- amino-N-(2-morpholinoathyl)-2-phenyl-6-pteridincarboxamid
4,7-DIAMINO-N-(2-MORPHOLINOETHYL)-2-PHENYL-6-PTERIDINECARBOXAMIDE
6-PTERIDINECARBOXAMIDE, 4,7-DIAMINO-N-(2-(4-MORPHOLINYL)ETHYL)-2-PHENYL-
7-Amino-4-imino-N-[2-(morpholin-4-yl)ethyl]-2-phenyl-1,4-dihydropteridine-6-carboximidic acid