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Thiopurinol

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Identification
Molecular formula
C11H8N3O3S
CAS number
66-75-1
IUPAC name
4,6-dioxo-N-phenyl-2-sulfanyl-1H-pyrimidine-5-carboxamide
State
State

At room temperature, Thiopurinol is typically found in a solid form. It is stable under standard conditions, but may degrade if exposed to certain elements or high temperatures for extended periods.

Melting point (Celsius)
202.00
Melting point (Kelvin)
475.15
Boiling point (Celsius)
585.00
Boiling point (Kelvin)
858.15
General information
Molecular weight
244.27g/mol
Molar mass
244.2700g/mol
Density
1.4500g/cm3
Appearence

The compound appears as fine white to off-white crystals. It is generally utilized in its pure form for experimental or specific chemical research purposes. In larger amounts or under specific conditions, the color may slightly vary.

Comment on solubility

Solubility of 4,6-Dioxo-N-phenyl-2-sulfanyl-1H-pyrimidine-5-carboxamide

The solubility of 4,6-dioxo-N-phenyl-2-sulfanyl-1H-pyrimidine-5-carboxamide (C11H8N3O3S) can be influenced by various factors including polarity, temperature, and the presence of solvents. To better understand its solubility characteristics, consider the following:

  • Polarity: The compound features both polar functional groups, such as the carboxamide (–C(O)NH2) and sulfur group, which can increase its interaction with polar solvents like water.
  • Temperature: Generally, increasing temperature can enhance the solubility of most organic compounds, potentially making this substance more soluble in hot solvents.
  • Solvent Compatibility: This compound may have limited solubility in non-polar solvents due to its polar functional groups. However, it could be more soluble in polar organic solvents such as dimethyl sulfoxide (DMSO) or ethanol.

In summary, the solubility of 4,6-dioxo-N-phenyl-2-sulfanyl-1H-pyrimidine-5-carboxamide is expected to be:

  1. Higher in polar solvents
  2. Increased with rising temperature
  3. Lower in non-polar solvents

Ultimately, laboratory experimentation would be essential to determine the precise solubility parameters and behavior of this compound in various solvent systems.

Interesting facts

Interesting Facts about 4,6-Dioxo-N-phenyl-2-sulfanyl-1H-pyrimidine-5-carboxamide

The compound 4,6-dioxo-N-phenyl-2-sulfanyl-1H-pyrimidine-5-carboxamide is a fascinating member of the pyrimidine family, which holds significant importance in medicinal chemistry. Here are some engaging points to consider:

  • Versatile Applications: This compound is often studied for its potential in drug development, especially in areas related to cancer therapy and antimicrobial activity. Its structural features may interact with biological targets effectively.
  • Complex Structure: The presence of multiple functional groups including dioxo and sulfanyl significantly increases the reactivity of the compound, leading to various chemical transformations that could result in novel derivatives.
  • Heterocyclic Chemistry: As a pyrimidine derivative, this compound features a six-membered aromatic ring structure that includes nitrogen atoms. This class of compounds is well-known for their roles in nucleic acids and pharmaceuticals.
  • Research Significance: Scientists are continually interested in studying the pharmacological properties of compounds like this one. According to researchers, "the interactions between the various functional groups can lead to unexpected biological activities."

The exploration of 4,6-dioxo-N-phenyl-2-sulfanyl-1H-pyrimidine-5-carboxamide contributes to the broader understanding of pyrimidine derivatives in medicinal chemistry and their role in developing effective therapeutic agents.