Biochanin A | Solubility of Things

Identification

Molecular formula

C₁₆H₁₂O₅

CAS number

491-80-5

IUPAC name

4,5-dihydroxy-3-(4-methoxyphenyl)chromen-7-one

State

At room temperature, Biochanin A is a solid compound. It is typically found in powder form due to its crystalline nature.

Melting point (Celsius)

198.50

Melting point (Kelvin)

471.65

Boiling point (Celsius)

538.00

Boiling point (Kelvin)

811.15

General information

Molecular weight

284.27g/mol

Molar mass

284.2660g/mol

Density

1.3010g/cm³

Appearence

Biochanin A appears as a yellow crystalline solid in its pure form. The crystals are usually fine and powdery.

Comment on solubility

Solubility of 4,5-Dihydroxy-3-(4-methoxyphenyl)chromen-7-one

The solubility of 4,5-dihydroxy-3-(4-methoxyphenyl)chromen-7-one, or C₁₆H₁₂O₅, is an intriguing aspect of its chemistry. Here are some key points to consider:

Organic Solvents: This compound shows considerable solubility in various organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). Its aromatic and hydroxyl groups aid in forming favorable interactions with organic solvent molecules.
Aqueous Solubility: The solubility in aqueous solutions is relatively low. This is primarily due to its hydrophobic aromatic structure combined with the potential hydrogen bonding provided by the hydroxyl groups. These competing interactions can hinder solubility in water.
pH Influence: The pH of the solution can significantly affect solubility, as the ionization of hydroxyl groups may increase solubility in basic conditions. Under acidic conditions, the compound may remain largely undissociated, which typically results in reduced solubility.
Temperature Effects: As with many organic compounds, increasing temperature often enhances solubility. A rise in temperature can disrupt solute-solvent interactions, allowing for greater dissolution of the compound.

In summary, while 4,5-dihydroxy-3-(4-methoxyphenyl)chromen-7-one exhibits good solubility in **organic solvents**, its **aqueous solubility** remains limited due to its structure. Understanding these nuances in solubility can be crucial for applications in pharmaceuticals and materials science.

Interesting facts

Interesting Facts about 4,5-Dihydroxy-3-(4-methoxyphenyl)chromen-7-one

4,5-Dihydroxy-3-(4-methoxyphenyl)chromen-7-one, often referred to as a derivative of flavonoids, possesses several intriguing characteristics that are worth exploring:

Flavonoid Structure: This compound belongs to the flavonoid class of polyphenols, which are known for their extensive range of biological activities. Flavonoids are incredibly versatile, often exhibiting antioxidant, anti-inflammatory, and anticancer properties.
Antioxidant Potential: Many studies have highlighted the antioxidant capabilities of flavonoids. By scavenging free radicals, compounds like this one can help in protecting cells from oxidative damage, thereby playing a role in disease prevention.
Biological Activities: Research has uncovered that this compound may exhibit a variety of biological effects, including:

Antimicrobial properties
Anti-diabetic effects
Neuroprotective capabilities

Natural Sources: Many flavonoids, including derivatives of chromen-7-one, can be found in various fruits, vegetables, and plants. They are often responsible for the vibrant colors and flavors of these natural products.
Potential Applications: Due to its beneficial properties, this compound is researched for possible applications in pharmaceuticals and nutraceuticals, potentially contributing to health supplements.

Quote to Remember: "Nature itself is the best chemist." This encapsulates the essence of how compounds like 4,5-dihydroxy-3-(4-methoxyphenyl)chromen-7-one can be derived from and inspired by nature.

In summary, the study of 4,5-dihydroxy-3-(4-methoxyphenyl)chromen-7-one opens a gateway to understanding the profound connection between natural compounds and human health, showcasing the vital role chemistry plays in our exploration of medicinal properties.